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学科主题: 临床医学
题名:
HLA-mismatched/haploidentical hematopoietic stem cell transplantation: a field in which Chinese doctors are making great contributions
作者: Huang Xiao-jun
关键词: allogeneic hematopoietic stem cell transplantation ; haploidentical ; China
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2010-05-20
DOI: 10.3760/cma.j.issn.0366-6999.2010.10.001
卷: 123, 期:10, 页:1235-1240
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: BONE-MARROW-TRANSPLANTATION ; COLONY-STIMULATING FACTOR ; UNMANIPULATED HAPLOIDENTICAL BLOOD ; RISK ACUTE-LEUKEMIA ; HEMATOLOGIC MALIGNANCIES ; ANTITHYMOCYTE GLOBULIN ; CLINICAL-OUTCOMES ; UNRELATED DONORS ; DEPLETION ; CHILDREN
英文摘要:

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the best, or even the only, option for the cure of leukemia, especially for patients with high risk factors.(1) However, it is limited by the shortage of suitable donors, because only 25%-30% patients can find a human leukocyte antigen (HLA)-identical sibling donor. Although much progress has been made in finding a suitable unrelated donor or unrelated cord blood (UCB) due to the expansion of the worldwide unrelated donor program, the shortage of suitable donor remains an important issue for several reasons. The probability of finding a matched unrelated donor ranges from less than 10% in ethnic minorities to 60%-70% in Caucasians.(2) The complicated process in searching for an unrelated donor has an average of about 4 months from initiation of a search to the donation of stem cells. During this time some patients might relapse, even die while waiting for the transplantation.(3) Allo-HSCT using a matched unrelated donor is still associated with a high transplant-related mortality (TRM) and high long-term morbidity.(4,5) UCB transplantation offers the advantages of easy procurement, immediate availability, the absence of risk to donors, and the reduced risk of graft-versus-host disease (GVHD).(6) However, engraftment remains a significant problem, especially for adult patients.

语种: 英语
WOS记录号: WOS:000278219900001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56407
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China

Recommended Citation:
Huang Xiao-jun. HLA-mismatched/haploidentical hematopoietic stem cell transplantation: a field in which Chinese doctors are making great contributions[J]. CHINESE MEDICAL JOURNAL,2010,123(10):1235-1240.
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