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学科主题: 基础医学
题名:
Ryanodine receptor arrays: not just a pretty pattern?
作者: Yin, Chang-Cheng2,3; D′ Cruz, Leon G.1; Lai, F. Anthony1
刊名: TRENDS IN CELL BIOLOGY
发表日期: 2008-04-01
DOI: 10.1016/j.tcb.2008.02.003
卷: 18, 期:4, 页:149-156
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: CALCIUM-RELEASE CHANNEL ; CORBULAR SARCOPLASMIC-RETICULUM ; RABBIT CARDIAC-MUSCLE ; SKELETAL-MUSCLE ; CA2+ RELEASE ; MOLECULAR-CLONING ; HEART-MUSCLE ; SPARKS ; UNITS ; CELLS
英文摘要:

Ryanodine receptors (RyRs) are colossal membrane protein complexes that reside in the endoplasmic reticulum of skeletal and cardiac muscle myocytes and neurons, in addition to many non-excitable cells. They comprise high-conductance ion channels that mediate the massive release of Ca2+ ions from the endoplasmic reticulum into the cytoplasm. This is the trigger for contraction during each muscle excitation-contraction coupling cycle. Individual RyRs are believed to network with other RyRs indirectly, through diffusion of released Ca2+ ions, namely the Ca2+-induced Ca2+ release phenomenon. However, RyRs can intrinsically organize into a regular array resembling a distinctive checkerboard pattern, with each square-shaped receptor appearing to abut four neighbours at each corner. In this opinion article, we describe recent data showing structural interactions between RyR oligomers in reconstituted arrays, and we suggest that this provides strong evidence for direct inter-RyR communication through a novel, allosteric regulatory mechanism.

语种: 英语
WOS记录号: WOS:000255452300001
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56413
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Peking Univ, Ctr Protein Sci, Beijing 10083, Peoples R China
2.Cardiff Univ, Sch Med, Wales Heart Res Inst, Cardiff CF14 4XN, Wales
3.Peking Univ, Hlth Sci Ctr, Dept Biophys, Beijing 10083, Peoples R China

Recommended Citation:
Yin, Chang-Cheng,D&prime,Cruz, Leon G.,et al. Ryanodine receptor arrays: not just a pretty pattern?[J]. TRENDS IN CELL BIOLOGY,2008,18(4):149-156.
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