IR@PKUHSC  > 北京大学基础医学院  > 生物物理学系
学科主题基础医学
Ryanodine receptor arrays: not just a pretty pattern?
Yin, Chang-Cheng2,3; D′ Cruz, Leon G.1; Lai, F. Anthony1
刊名TRENDS IN CELL BIOLOGY
2008-04-01
DOI10.1016/j.tcb.2008.02.003
18期:4页:149-156
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]CALCIUM-RELEASE CHANNEL ; CORBULAR SARCOPLASMIC-RETICULUM ; RABBIT CARDIAC-MUSCLE ; SKELETAL-MUSCLE ; CA2+ RELEASE ; MOLECULAR-CLONING ; HEART-MUSCLE ; SPARKS ; UNITS ; CELLS
英文摘要

Ryanodine receptors (RyRs) are colossal membrane protein complexes that reside in the endoplasmic reticulum of skeletal and cardiac muscle myocytes and neurons, in addition to many non-excitable cells. They comprise high-conductance ion channels that mediate the massive release of Ca2+ ions from the endoplasmic reticulum into the cytoplasm. This is the trigger for contraction during each muscle excitation-contraction coupling cycle. Individual RyRs are believed to network with other RyRs indirectly, through diffusion of released Ca2+ ions, namely the Ca2+-induced Ca2+ release phenomenon. However, RyRs can intrinsically organize into a regular array resembling a distinctive checkerboard pattern, with each square-shaped receptor appearing to abut four neighbours at each corner. In this opinion article, we describe recent data showing structural interactions between RyR oligomers in reconstituted arrays, and we suggest that this provides strong evidence for direct inter-RyR communication through a novel, allosteric regulatory mechanism.

语种英语
WOS记录号WOS:000255452300001
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被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56413
专题北京大学基础医学院_生物物理学系
作者单位1.Peking Univ, Ctr Protein Sci, Beijing 10083, Peoples R China
2.Cardiff Univ, Sch Med, Wales Heart Res Inst, Cardiff CF14 4XN, Wales
3.Peking Univ, Hlth Sci Ctr, Dept Biophys, Beijing 10083, Peoples R China
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GB/T 7714
Yin, Chang-Cheng,D&prime,Cruz, Leon G.,et al. Ryanodine receptor arrays: not just a pretty pattern?[J]. TRENDS IN CELL BIOLOGY,2008,18(4):149-156.
APA Yin, Chang-Cheng,D&prime,Cruz, Leon G.,&Lai, F. Anthony.(2008).Ryanodine receptor arrays: not just a pretty pattern?.TRENDS IN CELL BIOLOGY,18(4),149-156.
MLA Yin, Chang-Cheng,et al."Ryanodine receptor arrays: not just a pretty pattern?".TRENDS IN CELL BIOLOGY 18.4(2008):149-156.
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