IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Impact of surgery and epirubicin intravesical chemotherapy on peripheral blood dendritic cell subsets in patients with superficial urothelial carcinoma of the bladder
Feng Lang1; Ma Lin-lin2; Zhang Yu-hai1; Tian Ye1; Qu Chen-xue3; Wang Yang4
关键词Dendritic Cells Urothelial Carcinoma Of Bladder Intravesical Instillation Recurrence
刊名CHINESE MEDICAL JOURNAL
2012-04-05
DOI10.3760/cma.j.issn.0366-6999.2012.07.012
125期:7页:1254-1260
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]General & Internal Medicine
关键词[WOS]PANCREATIC-CANCER ; RESPONSES ; MATURATION ; MONOCYTE ; ADENOCARCINOMA ; RECURRENCE ; OUTCOMES ; IMMUNE ; TUMOR ; STAGE
英文摘要

Background Superficial urothelial carcinoma (SUC) of the bladder is a common urinary tract tumor in China. There is a high recurrence rate of this tumor even after surgery and intravesical instillation. Previous reports have described a suppression of the immune system in cancer patients. Dendritic cells (DCs) play a pivotal role in the induction of an effective antitumor immune response. The aim of this study was to investigate the effects of surgery and epirubicin intravesical chemotherapy (IC) on peripheral blood DCs in subsets of patients with bladder SUC.

Methods A total of 66 SUC patients and 38 healthy controls were enrolled in this study. All the patients had undergone transurethral resection (TUR) of their cancer and adjunctive IC after tumor removal. The patients were divided into a non-recurrence group (n=40) and a recurrence group (n=26) based on the presence or absence of tumor recurrence. Blood samples were taken preoperatively (PreOP), on postoperative days (POD) 1 and 7, and at postoperative month (POM) 3. Flow cytometric analysis was used for the determination and quantitation of the surface markers CD80 and CD86 in circulating DC subsets.

Results The preoperative percentages of myeloid dendritic cells (mDCs) and expression of CD80 and CD86 were impaired in SUC patients compared to healthy controls (P <0.05). The percentages of mDCs and these surface markers decreased significantly on POD 1 and increased on POD 7, remaining higher than the preoperative values in POM 3 (P <0.05). The percentages of mDCs, and CD80 and CD86 in the non-recurrence group on PreOP, POD 7, and POM 3 were higher than those in recurrence group.

Conclusions Surgical removal of SUC and adjunctive IC were associated with improved circulating mDC counts and function. Persistent depression of mDC counts and function after treatment in recurrence patients indicated lower antitumor immunity that may lead to tumor recurrence. Chin Med J 2012;125(7):1254-1260

语种英语
所属项目编号30772170
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000302882600012
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56422
专题北京大学第一临床医学院
作者单位1.Capital Med Univ, Fac Urol, Beijing 100050, Peoples R China
2.Capital Med Univ, Beijing Friendship Hosp, Dept Urol, Beijing 100050, Peoples R China
3.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China
4.Capital Med Univ, Tongren Hosp, Dept Lab Ctr, Beijing 100730, Peoples R China
推荐引用方式
GB/T 7714
Feng Lang,Ma Lin-lin,Zhang Yu-hai,et al. Impact of surgery and epirubicin intravesical chemotherapy on peripheral blood dendritic cell subsets in patients with superficial urothelial carcinoma of the bladder[J]. CHINESE MEDICAL JOURNAL,2012,125(7):1254-1260.
APA Feng Lang,Ma Lin-lin,Zhang Yu-hai,Tian Ye,Qu Chen-xue,&Wang Yang.(2012).Impact of surgery and epirubicin intravesical chemotherapy on peripheral blood dendritic cell subsets in patients with superficial urothelial carcinoma of the bladder.CHINESE MEDICAL JOURNAL,125(7),1254-1260.
MLA Feng Lang,et al."Impact of surgery and epirubicin intravesical chemotherapy on peripheral blood dendritic cell subsets in patients with superficial urothelial carcinoma of the bladder".CHINESE MEDICAL JOURNAL 125.7(2012):1254-1260.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Feng Lang]的文章
[Ma Lin-lin]的文章
[Zhang Yu-hai]的文章
百度学术
百度学术中相似的文章
[Feng Lang]的文章
[Ma Lin-lin]的文章
[Zhang Yu-hai]的文章
必应学术
必应学术中相似的文章
[Feng Lang]的文章
[Ma Lin-lin]的文章
[Zhang Yu-hai]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。