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学科主题: 临床医学
题名:
Impact of surgery and epirubicin intravesical chemotherapy on peripheral blood dendritic cell subsets in patients with superficial urothelial carcinoma of the bladder
作者: Feng Lang1; Ma Lin-lin2; Zhang Yu-hai1; Tian Ye1; Qu Chen-xue3; Wang Yang4
关键词: dendritic cells ; urothelial carcinoma of bladder ; intravesical instillation ; recurrence
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2012-04-05
DOI: 10.3760/cma.j.issn.0366-6999.2012.07.012
卷: 125, 期:7, 页:1254-1260
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: PANCREATIC-CANCER ; RESPONSES ; MATURATION ; MONOCYTE ; ADENOCARCINOMA ; RECURRENCE ; OUTCOMES ; IMMUNE ; TUMOR ; STAGE
英文摘要:

Background Superficial urothelial carcinoma (SUC) of the bladder is a common urinary tract tumor in China. There is a high recurrence rate of this tumor even after surgery and intravesical instillation. Previous reports have described a suppression of the immune system in cancer patients. Dendritic cells (DCs) play a pivotal role in the induction of an effective antitumor immune response. The aim of this study was to investigate the effects of surgery and epirubicin intravesical chemotherapy (IC) on peripheral blood DCs in subsets of patients with bladder SUC.

Methods A total of 66 SUC patients and 38 healthy controls were enrolled in this study. All the patients had undergone transurethral resection (TUR) of their cancer and adjunctive IC after tumor removal. The patients were divided into a non-recurrence group (n=40) and a recurrence group (n=26) based on the presence or absence of tumor recurrence. Blood samples were taken preoperatively (PreOP), on postoperative days (POD) 1 and 7, and at postoperative month (POM) 3. Flow cytometric analysis was used for the determination and quantitation of the surface markers CD80 and CD86 in circulating DC subsets.

Results The preoperative percentages of myeloid dendritic cells (mDCs) and expression of CD80 and CD86 were impaired in SUC patients compared to healthy controls (P <0.05). The percentages of mDCs and these surface markers decreased significantly on POD 1 and increased on POD 7, remaining higher than the preoperative values in POM 3 (P <0.05). The percentages of mDCs, and CD80 and CD86 in the non-recurrence group on PreOP, POD 7, and POM 3 were higher than those in recurrence group.

Conclusions Surgical removal of SUC and adjunctive IC were associated with improved circulating mDC counts and function. Persistent depression of mDC counts and function after treatment in recurrence patients indicated lower antitumor immunity that may lead to tumor recurrence. Chin Med J 2012;125(7):1254-1260

语种: 英语
所属项目编号: 30772170
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000302882600012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56422
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Capital Med Univ, Fac Urol, Beijing 100050, Peoples R China
2.Capital Med Univ, Beijing Friendship Hosp, Dept Urol, Beijing 100050, Peoples R China
3.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China
4.Capital Med Univ, Tongren Hosp, Dept Lab Ctr, Beijing 100730, Peoples R China

Recommended Citation:
Feng Lang,Ma Lin-lin,Zhang Yu-hai,et al. Impact of surgery and epirubicin intravesical chemotherapy on peripheral blood dendritic cell subsets in patients with superficial urothelial carcinoma of the bladder[J]. CHINESE MEDICAL JOURNAL,2012,125(7):1254-1260.
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