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学科主题基础医学
Development of a rapid and sensitive liquid chromatography/tandem mass spectrometry method for the determination of 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]-ethane (BBSKE), a novel anti-cancer agent in rat plasma
Zhou, Hai-Yan1; Dou, Gui-Fang2; Meng, Zhi-Yun2; Lou, Ya-Qing1; Zhang, Guo-Liang1
关键词Bbske Lc/esi-ms/ms Rat Plasma
刊名BIOMEDICAL CHROMATOGRAPHY
2008-10-01
DOI10.1002/bmc.1034
22期:10页:1123-1129
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]THIOREDOXIN REDUCTASE INHIBITOR ; ORGANOSELENIUM COMPOUND ; CELL-LINES ; APOPTOSIS
英文摘要

A rapid and sensitive liquid chromatography/electrospray ionization tandem mass spectrometric (LC/ESI-MS/MS) method has been developed to determine 1, 2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]-ethane (BBSKE), a novel antineoplastic agent, in rat plasma. The analytes were separated on a C-18 column with a mobile phase of methanol-water (75:25, v/v) and detected using a triple-quadrupole mass spectrometer in positive mode with the selective reaction monitoring. The characteristic ion dissociation transitions were m/z 603.0 -> 448.9 for derivatized. BBSKE and m/z 631.0 -> 476.8 for derivatized internal standard. The assay was linear over a range of 1-1000 ng/mL with a lower limit of quantification of 1 ng/mL. Intra- and inter-day precisions were less than 9.6 and 5.0%, respectively, and the accuracy ranged from -5.2 to 4.0%. The validated method was successfully applied to the characterization of pharmacokinetic profile of BBSKE after oral administration in rats. Copyright (C) 2008 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000260522400010
项目编号30371665 ; Z0004105040311
资助机构National Natural Science foundation of China ; Project of Beijing Biotechnology Foundation
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56424
专题北京大学基础医学院_药理学系
作者单位1.Beijing Inst Transfus Med, Beijing 100850, Peoples R China
2.Beijing Univ, Basic Med Sch, Dept Pharmacol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Hai-Yan,Dou, Gui-Fang,Meng, Zhi-Yun,et al. Development of a rapid and sensitive liquid chromatography/tandem mass spectrometry method for the determination of 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]-ethane (BBSKE), a novel anti-cancer agent in rat plasma[J]. BIOMEDICAL CHROMATOGRAPHY,2008,22(10):1123-1129.
APA Zhou, Hai-Yan,Dou, Gui-Fang,Meng, Zhi-Yun,Lou, Ya-Qing,&Zhang, Guo-Liang.(2008).Development of a rapid and sensitive liquid chromatography/tandem mass spectrometry method for the determination of 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]-ethane (BBSKE), a novel anti-cancer agent in rat plasma.BIOMEDICAL CHROMATOGRAPHY,22(10),1123-1129.
MLA Zhou, Hai-Yan,et al."Development of a rapid and sensitive liquid chromatography/tandem mass spectrometry method for the determination of 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]-ethane (BBSKE), a novel anti-cancer agent in rat plasma".BIOMEDICAL CHROMATOGRAPHY 22.10(2008):1123-1129.
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