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学科主题: 临床医学
题名:
Motor function recovery during peripheral nerve multiple regeneration
作者: An, Shuai; Zhang, Peixun; Peng, Jianping; Deng, Lei; Wang, Zhenwei; Wang, Zhiyong; Wang, Yanhua; Yin, Xiaofeng; Kou, Yuhui; Ha, Na; Jiang, Baoguo
关键词: functional recovery ; motor end plate ; multiple regeneration
刊名: JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
发表日期: 2015-04-01
DOI: 10.1002/term.1833
卷: 9, 期:4, 页:415-423
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell & Tissue Engineering ; Biotechnology & Applied Microbiology ; Cell Biology ; Engineering, Biomedical
研究领域[WOS]: Cell Biology ; Biotechnology & Applied Microbiology ; Engineering
关键词[WOS]: NEUROMUSCULAR-JUNCTIONS ; SYNAPTIC COMPETITION ; TIBIALIS ANTERIOR ; TRANSGENIC MICE ; REINNERVATION ; AXON ; RAT ; NEURORRHAPHY ; SPECIFICITY ; COLLATERALS
英文摘要:

Neuronal functional compensation and multiple regenerating axon sprouting occur during peripheral nerve regeneration. Sprouting nerve buds were quantitatively maintained and had matured when multiple injured distal nerves were anastomosed to smaller number of proximal nerve stumps; this has positive clinical significance for proximal stump damage. This study investigated whether sprouting axon buds would reinnervate the distal neuromuscular junction and maintain the function of the target organ under compensation conditions. The results showed that the sprouting axon buds maintained the numbers and morphology of motor end plates repaired by a smaller number of proximal nerve stumps, and recovered 80.0% tetanic muscle force compared with the normal side. Meanwhile, nerve conduction velocity, compound muscle action potential and diameter of muscular fibres declined 72.7%, 73.2% and 61.8%, respectively, compared with normal. This observation indicates the potential functional reserve of neurons and that it is feasible to repair nerve fibre injury through anastomosis of multiple distal nerve stumps with a smaller number of proximal nerve stumps, within the limits of compensation. Copyright (c) 2013 John Wiley & Sons, Ltd.

语种: 英语
所属项目编号: 30625036 ; 2005CB522604 ; 30801169 ; A-2008-10 ; 31171150 ; 81171146 ; 30971526 ; 31040043
项目资助者: Chinese National Natural Science Fund for Outstanding Youth ; Chinese 973 Project Planning ; Chinese National Natural Science Youth Fund ; Beijing City Science &amp ; Technology New Star Classification ; Chinese National Natural Science Fund ; Chinese Educational Ministry New Century Excellent Talent Support Project
WOS记录号: WOS:000353034100009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56428
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
An, Shuai,Zhang, Peixun,Peng, Jianping,et al. Motor function recovery during peripheral nerve multiple regeneration[J]. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE,2015,9(4):415-423.
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