IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Motor function recovery during peripheral nerve multiple regeneration
An, Shuai; Zhang, Peixun; Peng, Jianping; Deng, Lei; Wang, Zhenwei; Wang, Zhiyong; Wang, Yanhua; Yin, Xiaofeng; Kou, Yuhui; Ha, Na; Jiang, Baoguo
关键词Functional Recovery Motor End Plate Multiple Regeneration
刊名JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
2015-04-01
DOI10.1002/term.1833
9期:4页:415-423
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell & Tissue Engineering ; Biotechnology & Applied Microbiology ; Cell Biology ; Engineering, Biomedical
研究领域[WOS]Cell Biology ; Biotechnology & Applied Microbiology ; Engineering
关键词[WOS]NEUROMUSCULAR-JUNCTIONS ; SYNAPTIC COMPETITION ; TIBIALIS ANTERIOR ; TRANSGENIC MICE ; REINNERVATION ; AXON ; RAT ; NEURORRHAPHY ; SPECIFICITY ; COLLATERALS
英文摘要

Neuronal functional compensation and multiple regenerating axon sprouting occur during peripheral nerve regeneration. Sprouting nerve buds were quantitatively maintained and had matured when multiple injured distal nerves were anastomosed to smaller number of proximal nerve stumps; this has positive clinical significance for proximal stump damage. This study investigated whether sprouting axon buds would reinnervate the distal neuromuscular junction and maintain the function of the target organ under compensation conditions. The results showed that the sprouting axon buds maintained the numbers and morphology of motor end plates repaired by a smaller number of proximal nerve stumps, and recovered 80.0% tetanic muscle force compared with the normal side. Meanwhile, nerve conduction velocity, compound muscle action potential and diameter of muscular fibres declined 72.7%, 73.2% and 61.8%, respectively, compared with normal. This observation indicates the potential functional reserve of neurons and that it is feasible to repair nerve fibre injury through anastomosis of multiple distal nerve stumps with a smaller number of proximal nerve stumps, within the limits of compensation. Copyright (c) 2013 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000353034100009
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56428
Collection北京大学第二临床医学院
北京大学基础医学院
北京大学第二临床医学院_创伤骨科
北京大学第二临床医学院_党委院长办公室
作者单位Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
An, Shuai,Zhang, Peixun,Peng, Jianping,et al. Motor function recovery during peripheral nerve multiple regeneration[J]. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE,2015,9(4):415-423.
APA An, Shuai.,Zhang, Peixun.,Peng, Jianping.,Deng, Lei.,Wang, Zhenwei.,...&Jiang, Baoguo.(2015).Motor function recovery during peripheral nerve multiple regeneration.JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE,9(4),415-423.
MLA An, Shuai,et al."Motor function recovery during peripheral nerve multiple regeneration".JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE 9.4(2015):415-423.
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