北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学公共卫生学院  > 毒理学系  > 期刊论文
学科主题: 公共卫生
题名:
Diethyl sulfate induced Cdk2-dependent centrosome amplification in CHL cells
作者: Hu, Entan; Fu, Juanling; Zhao, Peng; Yao, Biyun; Qi, Yanmin; Yuan, Zhun; Zhou, Zongcan
关键词: Diethyl sulfate ; Centrosome amplification ; Cdk2
刊名: TOXICOLOGY
发表日期: 2010-09-10
DOI: 10.1016/j.tox.2010.06.001
卷: 275, 期:1-3, 页:58-64
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ; Toxicology
关键词[WOS]: HAMSTER V79 CELLS ; TRIVALENT DIMETHYLARSENIC COMPOUND ; MULTIPOLAR SPINDLES ; GAMMA-TUBULIN ; MULTINUCLEATED CELLS ; CYCLIN-E ; INDUCTION ; ANEUPLOIDY ; ABNORMALITY ; CHROMOSOME
英文摘要:

The function of centrosome that serves as the main microtubule organizing center is essential to ensure the genomic integrity during the cell division cycle. Centrosome abnormalities are frequently observed in many tumors and cells exposed to genotoxic agents. Here, we investigated the centrosome abnormalities induced by diethyl sulfate (DES) in Chinese hamster lung (CHL) fibroblasts and the underlying molecular mechanisms. Our results showed that DES exposure at 0.3, 1 and 3 mM for 48 h caused centrosome amplification in a dose dependent manner. This effect was associated with transient S and G2/M phase delay and up-regulating of Cdk2, Cyclin A expressions. Furthermore, inhibition of Cdk2 activities reversed the centrosome amplification induced by DES. These results reveal that centrosome is one of the key subcellular targets of DES. Centrosome abnormalities might be important mechanisms behind the aneuploidy induction and carcinogenicity of DES.(C) 2010 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2002CB12906
项目资助者: China National Key Basic Research and Development Program
WOS记录号: WOS:000280953600007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56430
Appears in Collections:北京大学公共卫生学院_毒理学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Hlth Sci Ctr, Dept Toxicol, Beijing 100191, Peoples R China

Recommended Citation:
Hu, Entan,Fu, Juanling,Zhao, Peng,et al. Diethyl sulfate induced Cdk2-dependent centrosome amplification in CHL cells[J]. TOXICOLOGY,2010,275(1-3):58-64.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Hu, Entan]'s Articles
[Fu, Juanling]'s Articles
[Zhao, Peng]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Hu, Entan]‘s Articles
[Fu, Juanling]‘s Articles
[Zhao, Peng]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace