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Diethyl sulfate induced Cdk2-dependent centrosome amplification in CHL cells
Hu, Entan; Fu, Juanling; Zhao, Peng; Yao, Biyun; Qi, Yanmin; Yuan, Zhun; Zhou, Zongcan
关键词Diethyl Sulfate Centrosome Amplification Cdk2
刊名TOXICOLOGY
2010-09-10
DOI10.1016/j.tox.2010.06.001
275期:1-3页:58-64
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Toxicology
资助者China National Key Basic Research and Development Program ; China National Key Basic Research and Development Program
研究领域[WOS]Pharmacology & Pharmacy ; Toxicology
关键词[WOS]HAMSTER V79 CELLS ; TRIVALENT DIMETHYLARSENIC COMPOUND ; MULTIPOLAR SPINDLES ; GAMMA-TUBULIN ; MULTINUCLEATED CELLS ; CYCLIN-E ; INDUCTION ; ANEUPLOIDY ; ABNORMALITY ; CHROMOSOME
英文摘要

The function of centrosome that serves as the main microtubule organizing center is essential to ensure the genomic integrity during the cell division cycle. Centrosome abnormalities are frequently observed in many tumors and cells exposed to genotoxic agents. Here, we investigated the centrosome abnormalities induced by diethyl sulfate (DES) in Chinese hamster lung (CHL) fibroblasts and the underlying molecular mechanisms. Our results showed that DES exposure at 0.3, 1 and 3 mM for 48 h caused centrosome amplification in a dose dependent manner. This effect was associated with transient S and G2/M phase delay and up-regulating of Cdk2, Cyclin A expressions. Furthermore, inhibition of Cdk2 activities reversed the centrosome amplification induced by DES. These results reveal that centrosome is one of the key subcellular targets of DES. Centrosome abnormalities might be important mechanisms behind the aneuploidy induction and carcinogenicity of DES.(C) 2010 Elsevier Ireland Ltd. All rights reserved.

语种英语
所属项目编号2002CB12906
资助者China National Key Basic Research and Development Program ; China National Key Basic Research and Development Program
WOS记录号WOS:000280953600007
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56430
专题北京大学公共卫生学院_毒理学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Toxicol, Beijing 100191, Peoples R China
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GB/T 7714
Hu, Entan,Fu, Juanling,Zhao, Peng,et al. Diethyl sulfate induced Cdk2-dependent centrosome amplification in CHL cells[J]. TOXICOLOGY,2010,275(1-3):58-64.
APA Hu, Entan.,Fu, Juanling.,Zhao, Peng.,Yao, Biyun.,Qi, Yanmin.,...&Zhou, Zongcan.(2010).Diethyl sulfate induced Cdk2-dependent centrosome amplification in CHL cells.TOXICOLOGY,275(1-3),58-64.
MLA Hu, Entan,et al."Diethyl sulfate induced Cdk2-dependent centrosome amplification in CHL cells".TOXICOLOGY 275.1-3(2010):58-64.
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