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学科主题: 公共卫生
题名:
Clinical progression and predictors of death in patients with severe fever with thrombocytopenia syndrome in China
作者: Cui, Ning1; Bao, Xiao-Lei2; Yang, Zhen-Dong1; Lu, Qing-Bin3; Hu, Chun-Yan4; Wang, Li-Yuan4,5; Wang, Bing-Jun1; Wang, Hong-Yu4,5; Liu, Kun4; Yuan, Chun1; Fan, Xue-Juan1; Wang, Zhen1; Zhang, Lan1; Zhang, Xiao-Ai4; Hu, Liang-Ping2; Liu, Wei4; Cao, Wu-Chun4
关键词: SFTS ; Clinical progression ; Predictors of death
刊名: JOURNAL OF CLINICAL VIROLOGY
发表日期: 2014
DOI: 10.1016/j.jcv.2013.10.024
卷: 59, 期:1, 页:12-17
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Virology
研究领域[WOS]: Virology
关键词[WOS]: TO-PERSON TRANSMISSION ; SYNDROME BUNYAVIRUS ; SYNDROME VIRUS ; DISEASE ; PATHOGENESIS ; DIAGNOSIS ; CONTACT ; CLUSTER ; BLOOD
英文摘要:

Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease of which the clinical progression and factors related to death are still unclear.

Objective: To identify the clinical progression of SFTS and explore predictors of fatal outcome throughout the disease progress.

Study design: A prospective study was performed in a general hospital located in Xinyang city during 2011-2013. Confirmed SFTS patients were recruited and laboratory parameters that were commonly evaluated in clinical practice were collected. The clinical progression was determined based on analysis of dynamic profiles and Friedman′s test. At each clinical stage, the laboratory features that could be used to predict fatal outcome of SFTS patients were identified by stepwise discriminant analysis.

Results: Totally 257 survivors and 54 deceased SFTS patients were recruited and the data of 11 clinical and laboratory parameters along their entire disease course were consecutively collected. Three clinical stages (day 1-5 post onset, day 6-11 post onset and day 12 to hospital discharge) were determined based on distinct clinical parameters evaluations. Multivariate discriminant analysis at each clinical stage disclosed the indicators of the fatal outcome as decreased platelet counts at early stage, older age and increased AST level at middle stage, and decreased lymphocyte percentage and increased LDH level at late stage.

Conclusions: The significant indicators at three clinical stages could be used to assist identifying the patients with high risk of death. This knowledge might help to perform supportive treatment and avoid fatality. (C) 2013 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 81222037 ; 81290344 ; 81130086 ; 81072250 ; 2013ZX10004-202
项目资助者: Natural Science Foundation of China ; China Mega-Project for Infectious Diseases grant
WOS记录号: WOS:000329408700003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56433
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Anhui Med Univ, Grad Sch, Hefei, Peoples R China
2.Peoples Liberat Army, Hosp 154, Xinyang 464000, Peoples R China
3.Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China
4.Acad Mil Med Sci, Consulting Ctr Biomed Stat, Beijing 100850, Peoples R China
5.Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China

Recommended Citation:
Cui, Ning,Bao, Xiao-Lei,Yang, Zhen-Dong,et al. Clinical progression and predictors of death in patients with severe fever with thrombocytopenia syndrome in China[J]. JOURNAL OF CLINICAL VIROLOGY,2014,59(1):12-17.
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