IR@PKUHSC  > 北京大学第三临床医学院  > 耳鼻喉科
学科主题临床医学
Effects of salicylate on serotoninergic activities in rat inferior colliculus and auditory cortex
Liu, JX; Li, XP; Wang, L; Dong, Y; Han, HW; Liu, GQ
关键词Salicylate Tinnitus Inferior Colliculus Auditory Cortex 5-ht Microdialysis
刊名HEARING RESEARCH
2003
175期:1-2页:45-53
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Audiology & Speech-Language Pathology ; Neurosciences ; Otorhinolaryngology
研究领域[WOS]Audiology & Speech-Language Pathology ; Neurosciences & Neurology ; Otorhinolaryngology
关键词[WOS]FREELY MOVING RAT ; AMINO-ACIDS ; PERCEPTION TINNITUS ; NEURAL ACTIVITY ; INVIVO RELEASE ; GLUCOSE-LEVELS ; LIMBIC SYSTEM ; ANIMAL-MODEL ; BLOOD-FLOW ; GUINEA-PIG
英文摘要

In vivo microdialysis offers a unique approach to monitor biochemical events related to brain function and metabolism, and has been used extensively in many systems to measure the release of endogenous transmitters and other neuroactive substances during normal and pathological conditions. The characterization of neurotransmitters′ changes induced by salicylate in the inferior colliculus (IC) and the auditory cortex (AC) may provide insight into the action of salicylate on the auditory system and, through this, provide a better understanding of neurological mechanism of salicylate-induced tinnitus. In the present study, the effect of salicylate on 5-HT system in IC and AC has been monitored by microdialysis in salicylate-induced tinnitus animal models. Glucose and lactate levels in IC and AC were significantly increased after application of salicylate (350 mg/kg, i.p.), indicating a salicylate-related increase in regional neuronal activity. The 5-HT level increased to a maximum of 268 +/- 27% basal level in IC 2 It after application and of 277 +/- 24% basal level in AC around 3 h after application. These data suggest that the increases of 5-HT levels in IC and AC may be involved in the tinnitus generation. (C) 2002 Elsevier Science B.V. All rights reserved.

语种英语
WOS记录号WOS:000180567300005
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56434
Collection北京大学第三临床医学院_耳鼻喉科
作者单位1.Peking Univ, Dept Otorhinolaryngol, Third Hosp, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Liu, JX,Li, XP,Wang, L,et al. Effects of salicylate on serotoninergic activities in rat inferior colliculus and auditory cortex[J]. HEARING RESEARCH,2003,175(1-2):45-53.
APA Liu, JX,Li, XP,Wang, L,Dong, Y,Han, HW,&Liu, GQ.(2003).Effects of salicylate on serotoninergic activities in rat inferior colliculus and auditory cortex.HEARING RESEARCH,175(1-2),45-53.
MLA Liu, JX,et al."Effects of salicylate on serotoninergic activities in rat inferior colliculus and auditory cortex".HEARING RESEARCH 175.1-2(2003):45-53.
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