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学科主题: 临床医学
题名:
Effects of salicylate on serotoninergic activities in rat inferior colliculus and auditory cortex
作者: Liu, JX; Li, XP; Wang, L; Dong, Y; Han, HW; Liu, GQ
关键词: salicylate ; tinnitus ; inferior colliculus ; auditory cortex ; 5-HT ; microdialysis
刊名: HEARING RESEARCH
发表日期: 2003
卷: 175, 期:1-2, 页:45-53
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Audiology & Speech-Language Pathology ; Neurosciences ; Otorhinolaryngology
研究领域[WOS]: Audiology & Speech-Language Pathology ; Neurosciences & Neurology ; Otorhinolaryngology
关键词[WOS]: FREELY MOVING RAT ; AMINO-ACIDS ; PERCEPTION TINNITUS ; NEURAL ACTIVITY ; INVIVO RELEASE ; GLUCOSE-LEVELS ; LIMBIC SYSTEM ; ANIMAL-MODEL ; BLOOD-FLOW ; GUINEA-PIG
英文摘要:

In vivo microdialysis offers a unique approach to monitor biochemical events related to brain function and metabolism, and has been used extensively in many systems to measure the release of endogenous transmitters and other neuroactive substances during normal and pathological conditions. The characterization of neurotransmitters′ changes induced by salicylate in the inferior colliculus (IC) and the auditory cortex (AC) may provide insight into the action of salicylate on the auditory system and, through this, provide a better understanding of neurological mechanism of salicylate-induced tinnitus. In the present study, the effect of salicylate on 5-HT system in IC and AC has been monitored by microdialysis in salicylate-induced tinnitus animal models. Glucose and lactate levels in IC and AC were significantly increased after application of salicylate (350 mg/kg, i.p.), indicating a salicylate-related increase in regional neuronal activity. The 5-HT level increased to a maximum of 268 +/- 27% basal level in IC 2 It after application and of 277 +/- 24% basal level in AC around 3 h after application. These data suggest that the increases of 5-HT levels in IC and AC may be involved in the tinnitus generation. (C) 2002 Elsevier Science B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000180567300005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56434
Appears in Collections:北京大学第三临床医学院_耳鼻喉科_期刊论文

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作者单位: 1.Peking Univ, Dept Otorhinolaryngol, Third Hosp, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China

Recommended Citation:
Liu, JX,Li, XP,Wang, L,et al. Effects of salicylate on serotoninergic activities in rat inferior colliculus and auditory cortex[J]. HEARING RESEARCH,2003,175(1-2):45-53.
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