IR@PKUHSC  > 北京大学第二临床医学院  > 急诊科
学科主题临床医学
Evaluation of respiratory dysfunction in a pig model of severe acute dichlorvos poisoning
He Xin-hua1; Wu Jun-yuan1; Li Chun-sheng1; Su Zhi-yu2; Ji Xian-fei3; Han Yi4; Wang Sheng-qi5; Zhang Jian1
关键词Dichlorvos Respiratory Dysfunction Acute Dichlorvos Poisoning Pulse Contour Cardiac Output Extravascular Lung Water Index
刊名CHINESE MEDICAL JOURNAL
2012-10-20
DOI10.3760/cma.j.issn.0366-6999.2012.20.003
125期:20页:3612-3618
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]EXTRAVASCULAR LUNG WATER ; CRITICALLY ILL PATIENTS ; TRANSPULMONARY THERMODILUTION ; CONTROLLED-TRIAL ; PULMONARY-EDEMA ; SEPSIS ; MANAGEMENT ; FAILURE ; HEALTH ; INJURY
英文摘要

Background Respiratory failure is the main cause of death in acute organophosphorus pesticide poisoning. In this study, a pulse-induced contour cardiac output monitor was used to evaluate the respiratory status in a pig model of acute dichlorvos poisoning.

Methods Twenty female pigs were randomly allocated to dichlorvos (n=7), atropine (n=7), and control (n=6) groups. In the dichlorvos group, pigs were administered 80% emulsifiable dichlorvos (100 mg/kg) via a gastric tube. In the atropine group, pigs were similarly administered dichlorvos, and 0.5 hours later, atropine was injected to attain and maintain atropinization. The control group was administered saline solution. Arterial blood gas was measured at 0, 0.5, 1, 2, 4, and 6 hours post-injection. The extravascular lung water index and pulmonary vascular permeability index were recorded by the pulse-induced contour cardiac output monitor. At termination of the study, the animals were euthanized, the lung wet-to-dry weight ratio was determined, and histopathology was observed.

Results In the dichlorvos group, the extravascular lung water index and pulmonary vascular permeability index were substantially increased from 0.5 hours and were particularly high within 1 hour. In the atropine group, these indices increased initially, but decreased from the 1-hour mark. The control group exhibited no obvious changes. In both the dichlorvos and atropine groups, the extravascular lung water index was negatively correlated with partial pressure of oxygen/fraction of inspiration oxygen (PO2/FiO(2)) and positively correlated with the pulmonary vascular permeability index. Compared with the control group, the lung wet-to-dry weight ratio markedly increased and the histopathological findings obviously changed in the dichlorvos group, but only mildly increased and changed, respectively, in the atropine group.

Conclusion The extravascular lung water index is an appropriate and valuable parameter for assessment of respiratory function in acute dichlorvos poisoning. Chin Med J 2012;125(20):3612-3618

语种英语
WOS记录号WOS:000311265100003
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56436
专题北京大学第二临床医学院_急诊科
作者单位1.Capital Med Univ, Beijng Chaoyang Hosp, Dept Emergency Med, Beijing 100020, Peoples R China
2.Peking Univ, Dept Emergency Med, Peoples Hosp, Beijing 100044, Peoples R China
3.Shandong Prov Hosp, Dept Emergency Med, Jinan 250021, Shandong, Peoples R China
4.Fudan Univ, Zhongshan Hosp, Dept Emergency Med, Shanghai 200032, Peoples R China
5.Capital Med Univ, Xuanwu Hosp, Dept Emergency Med, Beijing 100053, Peoples R China
推荐引用方式
GB/T 7714
He Xin-hua,Wu Jun-yuan,Li Chun-sheng,et al. Evaluation of respiratory dysfunction in a pig model of severe acute dichlorvos poisoning[J]. CHINESE MEDICAL JOURNAL,2012,125(20):3612-3618.
APA He Xin-hua.,Wu Jun-yuan.,Li Chun-sheng.,Su Zhi-yu.,Ji Xian-fei.,...&Zhang Jian.(2012).Evaluation of respiratory dysfunction in a pig model of severe acute dichlorvos poisoning.CHINESE MEDICAL JOURNAL,125(20),3612-3618.
MLA He Xin-hua,et al."Evaluation of respiratory dysfunction in a pig model of severe acute dichlorvos poisoning".CHINESE MEDICAL JOURNAL 125.20(2012):3612-3618.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[He Xin-hua]的文章
[Wu Jun-yuan]的文章
[Li Chun-sheng]的文章
百度学术
百度学术中相似的文章
[He Xin-hua]的文章
[Wu Jun-yuan]的文章
[Li Chun-sheng]的文章
必应学术
必应学术中相似的文章
[He Xin-hua]的文章
[Wu Jun-yuan]的文章
[Li Chun-sheng]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。