北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 急诊科  > 期刊论文
学科主题: 临床医学
题名:
Evaluation of respiratory dysfunction in a pig model of severe acute dichlorvos poisoning
作者: He Xin-hua1; Wu Jun-yuan1; Li Chun-sheng1; Su Zhi-yu2; Ji Xian-fei3; Han Yi4; Wang Sheng-qi5; Zhang Jian1
关键词: dichlorvos ; respiratory dysfunction ; acute dichlorvos poisoning ; pulse contour cardiac output ; extravascular lung water index
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2012-10-20
DOI: 10.3760/cma.j.issn.0366-6999.2012.20.003
卷: 125, 期:20, 页:3612-3618
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: EXTRAVASCULAR LUNG WATER ; CRITICALLY ILL PATIENTS ; TRANSPULMONARY THERMODILUTION ; CONTROLLED-TRIAL ; PULMONARY-EDEMA ; SEPSIS ; MANAGEMENT ; FAILURE ; HEALTH ; INJURY
英文摘要:

Background Respiratory failure is the main cause of death in acute organophosphorus pesticide poisoning. In this study, a pulse-induced contour cardiac output monitor was used to evaluate the respiratory status in a pig model of acute dichlorvos poisoning.

Methods Twenty female pigs were randomly allocated to dichlorvos (n=7), atropine (n=7), and control (n=6) groups. In the dichlorvos group, pigs were administered 80% emulsifiable dichlorvos (100 mg/kg) via a gastric tube. In the atropine group, pigs were similarly administered dichlorvos, and 0.5 hours later, atropine was injected to attain and maintain atropinization. The control group was administered saline solution. Arterial blood gas was measured at 0, 0.5, 1, 2, 4, and 6 hours post-injection. The extravascular lung water index and pulmonary vascular permeability index were recorded by the pulse-induced contour cardiac output monitor. At termination of the study, the animals were euthanized, the lung wet-to-dry weight ratio was determined, and histopathology was observed.

Results In the dichlorvos group, the extravascular lung water index and pulmonary vascular permeability index were substantially increased from 0.5 hours and were particularly high within 1 hour. In the atropine group, these indices increased initially, but decreased from the 1-hour mark. The control group exhibited no obvious changes. In both the dichlorvos and atropine groups, the extravascular lung water index was negatively correlated with partial pressure of oxygen/fraction of inspiration oxygen (PO2/FiO(2)) and positively correlated with the pulmonary vascular permeability index. Compared with the control group, the lung wet-to-dry weight ratio markedly increased and the histopathological findings obviously changed in the dichlorvos group, but only mildly increased and changed, respectively, in the atropine group.

Conclusion The extravascular lung water index is an appropriate and valuable parameter for assessment of respiratory function in acute dichlorvos poisoning. Chin Med J 2012;125(20):3612-3618

语种: 英语
WOS记录号: WOS:000311265100003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56436
Appears in Collections:北京大学第二临床医学院_急诊科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Capital Med Univ, Beijng Chaoyang Hosp, Dept Emergency Med, Beijing 100020, Peoples R China
2.Peking Univ, Dept Emergency Med, Peoples Hosp, Beijing 100044, Peoples R China
3.Shandong Prov Hosp, Dept Emergency Med, Jinan 250021, Shandong, Peoples R China
4.Fudan Univ, Zhongshan Hosp, Dept Emergency Med, Shanghai 200032, Peoples R China
5.Capital Med Univ, Xuanwu Hosp, Dept Emergency Med, Beijing 100053, Peoples R China

Recommended Citation:
He Xin-hua,Wu Jun-yuan,Li Chun-sheng,et al. Evaluation of respiratory dysfunction in a pig model of severe acute dichlorvos poisoning[J]. CHINESE MEDICAL JOURNAL,2012,125(20):3612-3618.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[He Xin-hua]'s Articles
[Wu Jun-yuan]'s Articles
[Li Chun-sheng]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[He Xin-hua]‘s Articles
[Wu Jun-yuan]‘s Articles
[Li Chun-sheng]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace