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学科主题: 临床医学
题名:
The impact of sodium aescinate on acute lung injury induced by oleic acid in rats
作者: Tian Wei2; Wang Tong3; Sun Wen-ping2; Deng Xiao-hui2; Xue Qiang2; Li Tian-shui2; Chen Zhi-fang2; Jin Hong-fang4; Ni Li1; Zhao Bin2; Du Jun-bao4; Ge Bao-ming1
关键词: acute lung injury (ALI) ; malondialdehyde (MDA) ; matrix metalloproteinase gelatinase B (MMP-9) ; oleic acid (OA) ; sodium aescinate (SA) ; superoxide dismutase (SOD) ; tissue inhibitor of metalloproteinase (TIMP-1)
刊名: EXPERIMENTAL LUNG RESEARCH
发表日期: 2011-12-01
DOI: 10.3109/01902148.2011.622426
卷: 37, 期:10, 页:585-599
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Respiratory System
研究领域[WOS]: Respiratory System
关键词[WOS]: RESPIRATORY-DISTRESS-SYNDROME ; MECHANISMS ; THERAPY ; EXTRACT ; ARDS
英文摘要:

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are associated with high rates of morbidity and mortality. Currently, several surfactant or anti-inflammatory drugs are under test as treatments for ALI. Sodium aescinate (SA) has been shown to exert anti-inflammatory and antiedematous effects. In the present work, the authors explored the effects of SA and the possible mechanisms of SA action in rats with ALI induced by oleic acid (OA) administration. Eight groups of rats received infusions of normal saline (NS) or OA. Rats exposed to OA were pretreated with 1 mg/kg of SA, or posttreated with SA at low (1 mg/kg), medium (2 mg/kg), or high (6 mg/kg) dose; a positive-control group received methylprednisolone. The pressure of oxygen in arterial blood (Po(2)) levels, the pulmonary wet/dry weight (W/D) ratios, and indices of quantitative assessment (IQA) of histological lung injury were obtained 2 or 6 hours after OA injection (0.1 mL/kg, intravenously). The levels of superoxide dismutase (SOD), malondialdehyde (MDA), matrix metalloproteinase gelatinase B (MMP-9), and tissue inhibitor of metalloproteinase (TIMP-1) in both plasma and lung tissue were also determined. Both pre- and posttreatment with SA improved OA-induced pulmonary injury, increased Po2 and SOD values, lowered IQA scores, and decreased the lung W/D ratio and MDA and MMP-9 levels in plasma and lung tissue. SA appeared to abrogate OA-induced ALI by modulating the levels of SOD, MDA, and MMP-9 in plasma and lung tissue.

语种: 英语
WOS记录号: WOS:000297057600002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56437
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Beijing Jishuitan Hosp, Beijing 100035, Peoples R China
2.Cooperat Ctr Chinese Clin Res, Beijing 100025, Peoples R China
3.Beijing Univ Tradit Chinese Med, Subsidiary Dongfang Hosp, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China

Recommended Citation:
Tian Wei,Wang Tong,Sun Wen-ping,et al. The impact of sodium aescinate on acute lung injury induced by oleic acid in rats[J]. EXPERIMENTAL LUNG RESEARCH,2011,37(10):585-599.
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