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学科主题: 临床医学
题名:
Hedysari Extract Improves Regeneration after Peripheral Nerve Injury by Enhancing the Amplification Effect
作者: Wang, Zhiyong; Zhang, Peixun; Kou, Yuhui; Yin, Xiaofeng; Han, Na; Jiang, Baoguo
刊名: PLOS ONE
发表日期: 2013-07-03
DOI: 10.1371/journal.pone.0067921
卷: 8, 期:7
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: GROWTH-FACTOR DELIVERY ; SPINAL-CORD ; AXON GROWTH ; SCHWANN ; CONDUITS ; CELLS ; RATS
英文摘要:

Radix Hedysari is an herbal preparation frequently used in traditional Chinese medicine. It can promote regeneration after peripheral nerve injury, but its effect on the amplification ratio (the ratio of distal to proximal fibers) during peripheral nerve regeneration has not yet been examined. In this study, we explored the effect of Hedysari extract on the amplification ratio in the peripheral nerve. Male Sprague-Dawley rats were separated into three groups at random: normal group (without surgery), model group (given sleeve nerve bridging surgery, but without adjuvant treatment) and treatment group (given sleeve nerve bridging surgery and then given Hedysari extract as adjuvant treatment). Twelve weeks after surgery, general observations, electrophysiological examination, histological analysis, morphometric measurements, and amplification ratio calculations were made. The results showed that nerve conduction velocity, the fiber and axon diameter, the g-ratio, the number of regenerating nerve fibers and the amplification ratio were better in the treatment group than in the model group, suggesting that Hedysari extract can effectively promote the growth of lateral buds in the proximal nerve stump and substantially improve the amplification effect during peripheral nerve regeneration.

语种: 英语
所属项目编号: 31171150 ; 31271284 ; 81171146 ; 30971526 ; 30801169 ; A-2008-10 ; BMU 20110270 ; 2007BAI04B06 ; 31100860
项目资助者: National Natural Science Fund ; Beijing City Science and Technology New Star Classification ; Educational Ministry New Century Excellent Talents Support Project ; National Eleven Five State Science and Technology Support Program ; National Natural Science Youth Science Fund
WOS记录号: WOS:000321733000115
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56441
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Dept Trauma & Orthoped, Peoples Hosp, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Zhiyong,Zhang, Peixun,Kou, Yuhui,et al. Hedysari Extract Improves Regeneration after Peripheral Nerve Injury by Enhancing the Amplification Effect[J]. PLOS ONE,2013,8(7).
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