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学科主题临床医学
Association between serum levels of 25-hydroxyvitamin D and osteoarthritis: a systematic review
Cao, Yuelong1,2; Winzenberg, Tania1; Nguo, Kay1; Lin, Jianhao3; Jones, Graeme1; Ding, Changhai1,4
关键词25-hydroxyvitamin d Osteoarthritis Systematic Review
刊名RHEUMATOLOGY
2013-07-01
DOI10.1093/rheumatology/ket132
52期:7页:1323-1334
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]VITAMIN-D SUPPLEMENTATION ; OLDER-ADULT COHORT ; KNEE OSTEOARTHRITIS ; HIP OSTEOARTHRITIS ; MUSCLE STRENGTH ; METAANALYSIS ; BONE ; CARTILAGE ; PROGRESSION ; HEALTH
英文摘要

Objective. To systematically review the evidence for association between serum 25-hydroxyvitamin D (25(OH) D) and OA and the effect of vitamin D therapy on OA.

Methods. An English Medline, EMBASE and Cochrane Library search for vitamin D and OA from January 1980 to June 2012 was performed. Randomized controlled trials (RCTs), cohort, case-control and cross-sectional studies in adults were included. The methodological quality of the selected studies was assessed and a best-evidence synthesis was used to summarize the results due to the heterogeneity of the studies.

Results. Of the 86 evaluated articles, 2 RCTs and 13 observational studies were included in the final analyses. The number of participants ranged from 64 to 1644 (0-100% women). The RCTs were only reported in abstract form and showed inconsistent results, most likely due to variations in their study design. There was insufficient or limited evidence for associations between 25-(OH)D and hand or hip OA. For knee radiographic OA as assessed by the Kellgren and Lawrence (KL) score, there was moderate evidence showing that low levels of 25-(OH)D were associated with increased progression of radiographic OA. Strong evidence for an association between 25-(OH)D and cartilage loss was apparent when joint space narrowing and changes in cartilage volume were considered collectively as cartilage loss.

Conclusion. 25-(OH)D appears to be implicated in structural changes of knee OA rather than symptoms, and further well-designed RCTs are required to determine whether vitamin D supplementation can slow disease progression. There is insufficient evidence for other sites.

语种英语
WOS记录号WOS:000321061200027
项目编号605501 ; 81072830
资助机构National Health and Medical Research Council (NHMRC) ; National Natural Science Foundation of China
引用统计
被引频次:46[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56444
专题北京大学第二临床医学院
作者单位1.Univ Tasmania, Menzies Res Inst Tasmania, Hobart, Tas 7000, Australia
2.Shanghai Univ Tradit Chinese Med, Res Inst Orthoped, Shuguang Hosp, Shanghai, Peoples R China
3.Peking Univ, Inst Bone & Joint, Peoples Hosp, Beijing, Peoples R China
4.Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia
推荐引用方式
GB/T 7714
Cao, Yuelong,Winzenberg, Tania,Nguo, Kay,et al. Association between serum levels of 25-hydroxyvitamin D and osteoarthritis: a systematic review[J]. RHEUMATOLOGY,2013,52(7):1323-1334.
APA Cao, Yuelong,Winzenberg, Tania,Nguo, Kay,Lin, Jianhao,Jones, Graeme,&Ding, Changhai.(2013).Association between serum levels of 25-hydroxyvitamin D and osteoarthritis: a systematic review.RHEUMATOLOGY,52(7),1323-1334.
MLA Cao, Yuelong,et al."Association between serum levels of 25-hydroxyvitamin D and osteoarthritis: a systematic review".RHEUMATOLOGY 52.7(2013):1323-1334.
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