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学科主题: 临床医学
题名:
Conflicting Impact of Alloreactive NK Cells on Transplantation Outcomes after Haploidentical Transplantation: Do the Reconstitution Kinetics of Natural Killer Cells Create These Differences?
作者: Zhao, Xiang-Yu; Chang, Ying-Jun; Huang, Xiao-Jun
关键词: HSCT ; GVHD ; NK ; Haploidentical
刊名: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
发表日期: 2011-10-01
DOI: 10.1016/j.bbmt.2011.05.020
卷: 17, 期:10, 页:1436-1442
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Immunology ; Transplantation
研究领域[WOS]: Hematology ; Immunology ; Transplantation
关键词[WOS]: HLA-MISMATCHED/HAPLOIDENTICAL BLOOD ; IMMUNOGLOBULIN-LIKE RECEPTORS ; BONE-MARROW-TRANSPLANTATION ; EXPRESSING INHIBITORY KIR ; ACUTE MYELOID-LEUKEMIA ; MISSING SELF ; T-CELLS ; HEMATOPOIETIC TRANSPLANTATION ; HEMATOLOGICAL MALIGNANCIES ; CLINICAL-OUTCOMES
英文摘要:

Partially HLA-mismatched related, or HLA-haploidentical, donor stem cell transplantation (SCT) is a feasible therapeutic option for advanced hematologic malignancy patients who lack an HLA-matched related or unrelated donor. Natural killer (NK) cells, a major cell type of the innate immune system, express surface receptors that regulate potent effector functions, such as cytolytic activity and the release of cytokines, and play a central role in the inflammatory response and immunoregulation. Conflicting results have been reported regarding the impact of NK cell alloreactivity on the outcome of haploidentical SCT in leukemic patients. This review summarizes the heterogeneous clinical results and explains the underlying mechanisms with respect to the reconstitution kinetics of NK cells and the interactions between NK cells and T cells. Biol Blood Marrow Transplant 17: 1436-1442 (2011) (C) 2011 American Society fir Blood and Marrow Transplantation

语种: 英语
所属项目编号: 30725038 ; 30971292 ; 30800485 ; 2008B05
项目资助者: National Outstanding Young Scientist&prime ; s Foundation of China ; National Natural Science Foundation of China ; Beijing Novel Program
WOS记录号: WOS:000295603400006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56446
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Zhao, Xiang-Yu,Chang, Ying-Jun,Huang, Xiao-Jun. Conflicting Impact of Alloreactive NK Cells on Transplantation Outcomes after Haploidentical Transplantation: Do the Reconstitution Kinetics of Natural Killer Cells Create These Differences?[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2011,17(10):1436-1442.
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