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Conflicting Impact of Alloreactive NK Cells on Transplantation Outcomes after Haploidentical Transplantation: Do the Reconstitution Kinetics of Natural Killer Cells Create These Differences?
Zhao, Xiang-Yu; Chang, Ying-Jun; Huang, Xiao-Jun
关键词Hsct Gvhd Nk Haploidentical
刊名BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
2011-10-01
DOI10.1016/j.bbmt.2011.05.020
17期:10页:1436-1442
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Hematology ; Immunology ; Transplantation
研究领域[WOS]Hematology ; Immunology ; Transplantation
关键词[WOS]HLA-MISMATCHED/HAPLOIDENTICAL BLOOD ; IMMUNOGLOBULIN-LIKE RECEPTORS ; BONE-MARROW-TRANSPLANTATION ; EXPRESSING INHIBITORY KIR ; ACUTE MYELOID-LEUKEMIA ; MISSING SELF ; T-CELLS ; HEMATOPOIETIC TRANSPLANTATION ; HEMATOLOGICAL MALIGNANCIES ; CLINICAL-OUTCOMES
英文摘要

Partially HLA-mismatched related, or HLA-haploidentical, donor stem cell transplantation (SCT) is a feasible therapeutic option for advanced hematologic malignancy patients who lack an HLA-matched related or unrelated donor. Natural killer (NK) cells, a major cell type of the innate immune system, express surface receptors that regulate potent effector functions, such as cytolytic activity and the release of cytokines, and play a central role in the inflammatory response and immunoregulation. Conflicting results have been reported regarding the impact of NK cell alloreactivity on the outcome of haploidentical SCT in leukemic patients. This review summarizes the heterogeneous clinical results and explains the underlying mechanisms with respect to the reconstitution kinetics of NK cells and the interactions between NK cells and T cells. Biol Blood Marrow Transplant 17: 1436-1442 (2011) (C) 2011 American Society fir Blood and Marrow Transplantation

语种英语
WOS记录号WOS:000295603400006
项目编号30725038 ; 30971292 ; 30800485 ; 2008B05
资助机构National Outstanding Young Scientist&prime ; s Foundation of China ; National Natural Science Foundation of China ; Beijing Novel Program
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56446
专题北京大学第二临床医学院_血液科
作者单位Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Xiang-Yu,Chang, Ying-Jun,Huang, Xiao-Jun. Conflicting Impact of Alloreactive NK Cells on Transplantation Outcomes after Haploidentical Transplantation: Do the Reconstitution Kinetics of Natural Killer Cells Create These Differences?[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2011,17(10):1436-1442.
APA Zhao, Xiang-Yu,Chang, Ying-Jun,&Huang, Xiao-Jun.(2011).Conflicting Impact of Alloreactive NK Cells on Transplantation Outcomes after Haploidentical Transplantation: Do the Reconstitution Kinetics of Natural Killer Cells Create These Differences?.BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,17(10),1436-1442.
MLA Zhao, Xiang-Yu,et al."Conflicting Impact of Alloreactive NK Cells on Transplantation Outcomes after Haploidentical Transplantation: Do the Reconstitution Kinetics of Natural Killer Cells Create These Differences?".BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 17.10(2011):1436-1442.
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