|Chronic Kidney Disease, All-Cause Mortality and Cardiovascular Mortality Among Chinese Patients with Established Cardiovascular Disease|
|Yang, Jin-gang1,2,3; Li, Jue4; Lu, Changlin5; Hasimu, Buaijiaer6; Yang, Yuejin1,2,3; Hu, Dayi7|
|关键词||Chronic Kidney Disease Cardiovascular Disease All-cause Mortality Cardiovascular Mortality|
|刊名||JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS|
|WOS标题词||Science & Technology|
|类目[WOS]||Peripheral Vascular Disease|
|研究领域[WOS]||Cardiovascular System & Cardiology|
|关键词[WOS]||GLOMERULAR-FILTRATION-RATE ; CORONARY-HEART-DISEASE ; RENAL-INSUFFICIENCY ; MYOCARDIAL-INFARCTION ; RANDOMIZED-TRIAL ; SERUM CREATININE ; ELDERLY-PATIENTS ; INCREASED RISK ; OUTCOMES ; ASSOCIATION|
Aim: This study was conducted to investigate the role of chronic kidney disease (CKD) in 1-year all-cause mortality and cardiovascular mortality among Chinese patients who were at least 50 years old and had a history of coronary artery disease (CAD), stroke, or peripheral vascular disease (PAD), or with two or more cardiovascular risks.
Methods: Of 3,732 hospitalized patients enrolled, 3,423 patients (91.7%) with complete data were eligible for 1-year follow-up. CKD was defined as an estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m(2).
Results: 1,166 (34.1%) were diagnosed with CKD. Most cases were unrecognized. Patients having an eGFR of <30 mL/min/1.73 m(2) were less likely to be prescribed beta-blockers, statins, or aspirin (all p < 0.001). A powerful relationship was observed between the severity of renal dysfunction and all causes of death or cardiovascular death. Adjusted for other covariates, the hazard ratio (HR) for all causes of death and for cardiovascular death among patients with an eGFR of 30-45 mL/min/1.73 m(2) was 1.70 (95% CI, 1.18-2.45) and 1.85 (95% CI, 1.12-3.01) as compared with 2.93 (95% CI, 1.96-4.38) and 3.47 (95% CI, 1.91-6.31) for patients with an eGFR of < 30 mL/min/1.73 m(2).
Conclusions: One third of Chinese patients at high risk for atherosclerotic events were diagnosed with CKD. Most of these cases were unrecognized and undertreated. An eGFR of < 45 mL/min/1.73 m(2) was an independent predictor of all causes of death and of cardiovascular death.
|资助机构||Beijing Nova Program|
|作者单位||1.Chinese Acad Med Sci, Cardiovasc Inst, Beijing 100037, Peoples R China|
2.Chinese Acad Med Sci, Fuwai Hosp, Beijing 100037, Peoples R China
3.Peking Union Med Coll, Beijing 100037, Peoples R China
4.Tongji Univ, Heart Lung & Blood Vessel Ctr, Shanghai 200092, Peoples R China
5.Beijing Med Univ, Beijing Tongren Hosp, Ctr Cardiovasc, Beijing 100083, Peoples R China
6.Xinjiang Med Univ, Teaching Hosp 1, Ctr Heart, Urumqi, Peoples R China
7.Peking Univ, Peoples Hosp, Ctr Heart, Beijing 100044, Peoples R China
|Yang, Jin-gang,Li, Jue,Lu, Changlin,et al. Chronic Kidney Disease, All-Cause Mortality and Cardiovascular Mortality Among Chinese Patients with Established Cardiovascular Disease[J]. JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS,2010,17(4):395-401.|
|APA||Yang, Jin-gang,Li, Jue,Lu, Changlin,Hasimu, Buaijiaer,Yang, Yuejin,&Hu, Dayi.(2010).Chronic Kidney Disease, All-Cause Mortality and Cardiovascular Mortality Among Chinese Patients with Established Cardiovascular Disease.JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS,17(4),395-401.|
|MLA||Yang, Jin-gang,et al."Chronic Kidney Disease, All-Cause Mortality and Cardiovascular Mortality Among Chinese Patients with Established Cardiovascular Disease".JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 17.4(2010):395-401.|