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学科主题: 临床医学
题名:
Chronic Kidney Disease, All-Cause Mortality and Cardiovascular Mortality Among Chinese Patients with Established Cardiovascular Disease
作者: Yang, Jin-gang1,2,3; Li, Jue4; Lu, Changlin5; Hasimu, Buaijiaer6; Yang, Yuejin1,2,3; Hu, Dayi7
关键词: Chronic kidney disease ; Cardiovascular disease ; All-cause mortality ; Cardiovascular mortality
刊名: JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
发表日期: 2010
卷: 17, 期:4, 页:395-401
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: GLOMERULAR-FILTRATION-RATE ; CORONARY-HEART-DISEASE ; RENAL-INSUFFICIENCY ; MYOCARDIAL-INFARCTION ; RANDOMIZED-TRIAL ; SERUM CREATININE ; ELDERLY-PATIENTS ; INCREASED RISK ; OUTCOMES ; ASSOCIATION
英文摘要:

Aim: This study was conducted to investigate the role of chronic kidney disease (CKD) in 1-year all-cause mortality and cardiovascular mortality among Chinese patients who were at least 50 years old and had a history of coronary artery disease (CAD), stroke, or peripheral vascular disease (PAD), or with two or more cardiovascular risks.

Methods: Of 3,732 hospitalized patients enrolled, 3,423 patients (91.7%) with complete data were eligible for 1-year follow-up. CKD was defined as an estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m(2).

Results: 1,166 (34.1%) were diagnosed with CKD. Most cases were unrecognized. Patients having an eGFR of <30 mL/min/1.73 m(2) were less likely to be prescribed beta-blockers, statins, or aspirin (all p < 0.001). A powerful relationship was observed between the severity of renal dysfunction and all causes of death or cardiovascular death. Adjusted for other covariates, the hazard ratio (HR) for all causes of death and for cardiovascular death among patients with an eGFR of 30-45 mL/min/1.73 m(2) was 1.70 (95% CI, 1.18-2.45) and 1.85 (95% CI, 1.12-3.01) as compared with 2.93 (95% CI, 1.96-4.38) and 3.47 (95% CI, 1.91-6.31) for patients with an eGFR of < 30 mL/min/1.73 m(2).

Conclusions: One third of Chinese patients at high risk for atherosclerotic events were diagnosed with CKD. Most of these cases were unrecognized and undertreated. An eGFR of < 45 mL/min/1.73 m(2) was an independent predictor of all causes of death and of cardiovascular death.

语种: 英语
所属项目编号: 2006B52
项目资助者: Beijing Nova Program
WOS记录号: WOS:000278406000010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56447
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Cardiovasc Inst, Beijing 100037, Peoples R China
2.Chinese Acad Med Sci, Fuwai Hosp, Beijing 100037, Peoples R China
3.Peking Union Med Coll, Beijing 100037, Peoples R China
4.Tongji Univ, Heart Lung & Blood Vessel Ctr, Shanghai 200092, Peoples R China
5.Beijing Med Univ, Beijing Tongren Hosp, Ctr Cardiovasc, Beijing 100083, Peoples R China
6.Xinjiang Med Univ, Teaching Hosp 1, Ctr Heart, Urumqi, Peoples R China
7.Peking Univ, Peoples Hosp, Ctr Heart, Beijing 100044, Peoples R China

Recommended Citation:
Yang, Jin-gang,Li, Jue,Lu, Changlin,et al. Chronic Kidney Disease, All-Cause Mortality and Cardiovascular Mortality Among Chinese Patients with Established Cardiovascular Disease[J]. JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS,2010,17(4):395-401.
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