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学科主题临床医学
Activation of Wnt/beta-catenin Pathway by Exogenous Wnt1 Protects SH-SY5Y Cells Against 6-Hydroxydopamine Toxicity
Wei, Lei1,2; Sun, Congcong1; Lei, Ming1; Li, Guofei3; Yi, Li4; Luo, Feifei5; Li, Yi6; Ding, Li7; Liu, Zhuolin1; Li, Shaomin8; Xu, Pingyi1
关键词Wnt1 Oxidative Stress Endoplasmic Reticulum (Er) Stress Parkinson&Prime s Disease
刊名JOURNAL OF MOLECULAR NEUROSCIENCE
2013
DOI10.1007/s12031-012-9900-8
49期:1页:105-115
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
资助者Ministry of Science and Technology of the People&prime ; s Republic of China ; Nature Science Foundation of China ; Guangzhou Foundation for Scientific and Technological Project, China ; Specialized Research Fund for the Doctoral Program of Higher Education of China ; Hainan Provincial Science and Technology Department ; Ministry of Science and Technology of the People&prime ; s Republic of China ; Nature Science Foundation of China ; Guangzhou Foundation for Scientific and Technological Project, China ; Specialized Research Fund for the Doctoral Program of Higher Education of China ; Hainan Provincial Science and Technology Department
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]ENDOPLASMIC-RETICULUM STRESS ; GLYCOGEN-SYNTHASE KINASE-3-BETA ; PARKINSONS-DISEASE ; SIGNALING PATHWAYS ; OXIDATIVE STRESS ; DEATH ; APOPTOSIS ; SURVIVAL ; NEURONS ; NEURODEGENERATION
英文摘要

Wnt1, initially described as a modulator of embryonic development, has recently been discovered to exert cytoprotective effects in cellular models of several diseases, including Parkinson′s disease (PD). We, therefore, examined the neuroprotective effects of exogenous Wnt1 on dopaminergic SH-SY5Y cells treated with 6-hydroxydopamine (6-OHDA). Here, we show that 10-500 mu M 6-OHDA treatment decreased cell viability and increased lactate dehydrogenase (LDH) leakage. SH-SY5Y cells treated with 100 mu M 6-OHDA for 24 h showed reduced Wnt/beta-catenin activity, decreased mitochondrial transmembrane potential, elevated levels of reactive oxidative species (ROS) and phosphatidylserine (PS) extraversion, increased levels of Chop and Bip/GRP78 and reduced level of p-Akt (Ser473). In contrast, exogenous Wnt1 attenuated 6-OHDA-induced changes. These results suggest that activation of the Wnt/beta-catenin pathway by exogenous Wnt1 protects against 6-OHDA-induced changes by restoring mitochondria and endoplasmic reticulum (ER) function.

语种英语
所属项目编号2007AA02Z460 ; 2010AB973Z531 ; 81071032 ; 81271428 ; 2012J4300061 ; 20100171110056 ; ZDXM080214
资助者Ministry of Science and Technology of the People&prime ; s Republic of China ; Nature Science Foundation of China ; Guangzhou Foundation for Scientific and Technological Project, China ; Specialized Research Fund for the Doctoral Program of Higher Education of China ; Hainan Provincial Science and Technology Department ; Ministry of Science and Technology of the People&prime ; s Republic of China ; Nature Science Foundation of China ; Guangzhou Foundation for Scientific and Technological Project, China ; Specialized Research Fund for the Doctoral Program of Higher Education of China ; Hainan Provincial Science and Technology Department
WOS记录号WOS:000312881900012
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56452
专题北京大学深圳医院_神经内科
作者单位1.Sun Yat Sen Univ, Dept Neurol, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China
2.Sun Yat Sen Univ, Dept Neurol, Affiliated Hosp 3, Guangzhou 510630, Guangdong, Peoples R China
3.Henan Univ Hosp Huaihe, Dept Neurol, Kaifeng 37500, Henan, Peoples R China
4.Beijing Univ, Dept Neurol, Shenzhen Hosp, Shenzhen 518036, Peoples R China
5.Chongqing Med Univ, Dept Neurol, Affiliated Hosp Chengdu 2, Peoples Hosp Chengdu 3, Chengdu 610031, Peoples R China
6.Jinan Univ, Dept Neurol, Guangzhou Red Cross Hosp, Affiliated Hosp 4, Guangzhou 510220, Guangdong, Peoples R China
7.Sun Yat Sen Univ, Dept Pathol, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China
8.Harvard Univ, Sch Med, Dept Neurol, Brigham & Womens Hosp, Boston, MA 02115 USA
推荐引用方式
GB/T 7714
Wei, Lei,Sun, Congcong,Lei, Ming,et al. Activation of Wnt/beta-catenin Pathway by Exogenous Wnt1 Protects SH-SY5Y Cells Against 6-Hydroxydopamine Toxicity[J]. JOURNAL OF MOLECULAR NEUROSCIENCE,2013,49(1):105-115.
APA Wei, Lei.,Sun, Congcong.,Lei, Ming.,Li, Guofei.,Yi, Li.,...&Xu, Pingyi.(2013).Activation of Wnt/beta-catenin Pathway by Exogenous Wnt1 Protects SH-SY5Y Cells Against 6-Hydroxydopamine Toxicity.JOURNAL OF MOLECULAR NEUROSCIENCE,49(1),105-115.
MLA Wei, Lei,et al."Activation of Wnt/beta-catenin Pathway by Exogenous Wnt1 Protects SH-SY5Y Cells Against 6-Hydroxydopamine Toxicity".JOURNAL OF MOLECULAR NEUROSCIENCE 49.1(2013):105-115.
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