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学科主题: 基础医学
题名:
Ectopic discharges from injured nerve fibers are highly correlated with tactile allodynia only in early, but not late, stage in rats with spinal nerve ligation
作者: Sun, Q; Tu, HY; Xing, GG; Han, JS; Wan, Y
关键词: ectopic discharge ; dorsal root ganglion ; neuropathic pain ; spinal nerve ligation ; teased fiber recording ; tactile allodynia
刊名: EXPERIMENTAL NEUROLOGY
发表日期: 2005
DOI: 10.1016/j.expneurol.2004.09.008
卷: 191, 期:1, 页:128-136
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: LONG-TERM POTENTIATION ; NEUROPATHIC PAIN BEHAVIORS ; ROOT GANGLION NEURONS ; ADRENERGIC SENSITIVITY ; DESCENDING FACILITATION ; STRAIN DIFFERENCES ; PATHOLOGICAL PAIN ; MODEL ; HYPERALGESIA ; AFFERENTS
英文摘要:

It is widely accepted that ectopic discharges originated from injured sites and dorsal root ganglion (DRG) neurons after peripheral nerve injury contribute to neuropathic pain. However, it has been recently shown that ectopic discharges were not always necessary for neuropathic pain. In the present study, we aim to further examine the role of ectopic discharges in neuropathic pain in a spinal nerve ligation (SNL) model. With teased fiber recordings in vivo, the characteristics of ectopic discharges were observed over 14 days after SNL, and the correlation between ectopic discharges and tactile allodynia was analyzed. It was observed that ectopic discharges have three firing patterns (tonic, bursting, and irregular) after SNL, and proportions of these three patterns changed dynamically over time. The tonic and bursting types were dominant in the first 24 h following SNL, while the irregular type became the only pattern in the late stage (day 14). The average frequencies of ectopic discharges and the percentage of active filaments also changed over time, reaching the peak 24 h after SNL and then declined gradually. Ectopic discharges were highly correlated with tactile allodynia in the first 24 h following SNL, but surprisingly, not in the late stage of days 1 to 14. These findings suggest that ectopic discharges may be crucial in the triggering of neuropathic pain in the early stage, but their importance become more limited over time. (C) 2004 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000226225900013
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56458
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: Peking Univ, Minist Educ, Key Lab Neurosci, Neurosci Res Inst, Beijing 100083, Peoples R China

Recommended Citation:
Sun, Q,Tu, HY,Xing, GG,et al. Ectopic discharges from injured nerve fibers are highly correlated with tactile allodynia only in early, but not late, stage in rats with spinal nerve ligation[J]. EXPERIMENTAL NEUROLOGY,2005,191(1):128-136.
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