IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
THE ROLE OF CHOROID PLEXUS IN IVIG-INDUCED BETA-AMYLOID CLEARANCE
Gu, H.1; Zhong, Z.1,2; Jiang, W.3; Du, E.1; Dodel, R.4; Liu, J.5; Farlow, M. R.1; Zheng, W.3; Du, Y.1,3
关键词Choroid Plexus Ivig Lrp1 a Beta Clearance
刊名NEUROSCIENCE
2014-06-13
DOI10.1016/j.neuroscience.2014.04.011
270页:168-176
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]RECEPTOR-RELATED PROTEIN ; CENTRAL-NERVOUS-SYSTEM ; TRANSGENIC MOUSE MODEL ; ALZHEIMERS-DISEASE ; A-BETA ; CEREBROSPINAL-FLUID ; LEAD-EXPOSURE ; BRAIN ; PEPTIDE ; BARRIER
英文摘要

We have shown that intravenous immunoglobulin (IVIG) contains anti-A beta autoantibodies and IVIG could induce beta amyloid (A beta) efflux from cerebrospinal fluid (CSF) to blood in both Multiple Sclerosis (MS) and Alzheimer disease (AD) patients. However, the molecular mechanism underlying IVIG-induced Ab efflux remains unclear. In this study, we used amyloid precursor protein (A beta PP) transgenic mice to investigate if the IVIG could induce efflux of A beta from the brain and whether low-density lipoprotein receptor-related protein-1 (LRP1), a hypothetic A beta transporter in blood-CSF barrier (BCB); could mediate this clearance process. We currently provide strong evidence to demonstrate that IVIG could reduce brain A beta levels by pulling Ab into the blood system in AbPP transgenic mice. In the mechanistic study, IVIG could induce A beta efflux through the in vitro BCB membrane formed by cultured BCB epithelial cells. Both receptor-associated protein (RAP; a functional inhibitor of LRP1), and LRP1 siRNA were able to significantly inhibit the A beta efflux. Should A beta prove to be the underlying cause of AD, our results strongly suggest that IVIG could be beneficial in the therapy for AD by inducing efflux of A beta from the brain through the LRP1 in the BCB. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000336624000016
项目编号R21 ES017055
资助机构NIH/NIEHS
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56462
专题北京大学第二临床医学院
作者单位1.Indiana Univ Sch Med, Dept Neurol, Indianapolis, IN 46202 USA
2.Peking Univ, Peoples Hosp, Dept Gen Surg, Beijing 100044, Peoples R China
3.Purdue Univ, Sch Hlth Sci, W Lafayette, IN 47907 USA
4.Univ Marburg, Dept Neurol, Marburg, Germany
5.Peking Univ, Sch Pharmaceut Sci, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Gu, H.,Zhong, Z.,Jiang, W.,et al. THE ROLE OF CHOROID PLEXUS IN IVIG-INDUCED BETA-AMYLOID CLEARANCE[J]. NEUROSCIENCE,2014,270:168-176.
APA Gu, H..,Zhong, Z..,Jiang, W..,Du, E..,Dodel, R..,...&Du, Y..(2014).THE ROLE OF CHOROID PLEXUS IN IVIG-INDUCED BETA-AMYLOID CLEARANCE.NEUROSCIENCE,270,168-176.
MLA Gu, H.,et al."THE ROLE OF CHOROID PLEXUS IN IVIG-INDUCED BETA-AMYLOID CLEARANCE".NEUROSCIENCE 270(2014):168-176.
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