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学科主题: 临床医学
题名:
THE ROLE OF CHOROID PLEXUS IN IVIG-INDUCED BETA-AMYLOID CLEARANCE
作者: Gu, H.1; Zhong, Z.1,2; Jiang, W.3; Du, E.1; Dodel, R.4; Liu, J.5; Farlow, M. R.1; Zheng, W.3; Du, Y.1,3
关键词: choroid plexus ; IVIG ; LRP1 ; A beta clearance
刊名: NEUROSCIENCE
发表日期: 2014-06-13
DOI: 10.1016/j.neuroscience.2014.04.011
卷: 270, 页:168-176
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: RECEPTOR-RELATED PROTEIN ; CENTRAL-NERVOUS-SYSTEM ; TRANSGENIC MOUSE MODEL ; ALZHEIMERS-DISEASE ; A-BETA ; CEREBROSPINAL-FLUID ; LEAD-EXPOSURE ; BRAIN ; PEPTIDE ; BARRIER
英文摘要:

We have shown that intravenous immunoglobulin (IVIG) contains anti-A beta autoantibodies and IVIG could induce beta amyloid (A beta) efflux from cerebrospinal fluid (CSF) to blood in both Multiple Sclerosis (MS) and Alzheimer disease (AD) patients. However, the molecular mechanism underlying IVIG-induced Ab efflux remains unclear. In this study, we used amyloid precursor protein (A beta PP) transgenic mice to investigate if the IVIG could induce efflux of A beta from the brain and whether low-density lipoprotein receptor-related protein-1 (LRP1), a hypothetic A beta transporter in blood-CSF barrier (BCB); could mediate this clearance process. We currently provide strong evidence to demonstrate that IVIG could reduce brain A beta levels by pulling Ab into the blood system in AbPP transgenic mice. In the mechanistic study, IVIG could induce A beta efflux through the in vitro BCB membrane formed by cultured BCB epithelial cells. Both receptor-associated protein (RAP; a functional inhibitor of LRP1), and LRP1 siRNA were able to significantly inhibit the A beta efflux. Should A beta prove to be the underlying cause of AD, our results strongly suggest that IVIG could be beneficial in the therapy for AD by inducing efflux of A beta from the brain through the LRP1 in the BCB. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: R21 ES017055
项目资助者: NIH/NIEHS
WOS记录号: WOS:000336624000016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56462
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Indiana Univ Sch Med, Dept Neurol, Indianapolis, IN 46202 USA
2.Peking Univ, Peoples Hosp, Dept Gen Surg, Beijing 100044, Peoples R China
3.Purdue Univ, Sch Hlth Sci, W Lafayette, IN 47907 USA
4.Univ Marburg, Dept Neurol, Marburg, Germany
5.Peking Univ, Sch Pharmaceut Sci, Beijing 100871, Peoples R China

Recommended Citation:
Gu, H.,Zhong, Z.,Jiang, W.,et al. THE ROLE OF CHOROID PLEXUS IN IVIG-INDUCED BETA-AMYLOID CLEARANCE[J]. NEUROSCIENCE,2014,270:168-176.
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