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学科主题: 药物依赖
题名:
Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals
作者: Yuan, Kai2; Qin, Wei2; Dong, Minghao2; Liu, Jixin2; Sun, Jinbo2; Liu, Peng2; Zhang, Yi2; Wang, Wei3; Wang, Yarong3; Li, Qiang3; Zhao, Liyan4; von Deneen, Karen M.5,6; Liu, Yijun5,6; Gold, Mark S.5,6; Tian, Jie1,2
关键词: Heroin ; Voxel-based morphometry ; Resting-state
刊名: NEUROSCIENCE LETTERS
发表日期: 2010-09-27
DOI: 10.1016/j.neulet.2010.07.005
卷: 482, 期:2, 页:101-105
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: VOXEL-BASED MORPHOMETRY ; FUNCTIONAL CONNECTIVITY ; PREFRONTAL CORTEX ; OPIATE DEPENDENCE ; DEFAULT MODE ; FMRI ; BRAIN ; CUES ; NETWORKS ; COCAINE
英文摘要:

Previous neuroimaging studies have demonstrated both structural and functional damages in heroin-dependent individuals. However, few studies investigated gray matter deficits and abnormal resting-state networks together in heroin-dependent individuals. In the present study, voxel-based morphometry (VBM) was used to identify brain regions with gray matter density reduction. Resting-state fMRI connectivity analysis was employed to assess potential functional abnormalities during resting-state. All clinical significances were investigated by examining their association with duration of heroin use. Compared with healthy subjects, heroin-dependent individuals showed significant reduction in gray matter density in the right dorsolateral prefrontal cortex (DLPFC) and a decrease in resting-state functional connectivity between the right DLPFC and left inferior parietal lobe (IPL). The gray matter density of the right DLPFC and its resting-state functional connectivity with the left IPL both showed significantly negative correlation with duration of heroin use, which were likely to be related to the functional impairments in decision-making and cognitive control exhibited by heroin-dependent individuals. Our findings demonstrated that long heroin dependence impairs the right DLPFC in heroin-dependent individuals, including structural deficits and resting-state functional impairments. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: IRT0645 ; KGCX2-YW-129 ; 30970774 ; 60901064 ; 30873462 ; 30870685 ; 2006CB705700 ; 2008AA01Z411
项目资助者: Changjiang Scholars and Innovative Research Team in University (PCSIRT) ; Ministry of Education of China ; CAS ; National Natural Science Foundation of China ; Project for the National Key Basic Research and Development Program (973) ; 863 program ; Fundamental Research Funds for the Central Universities
WOS记录号: WOS:000281473000005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56469
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
2.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Peoples R China
3.Fourth Mil Med Univ, Xian 710038, Shaanxi, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
5.Univ Florida, McKnight Brain Inst, Dept Psychiat, Gainesville, FL 32610 USA
6.Univ Florida, McKnight Brain Inst, Dept Neurosci, Gainesville, FL 32610 USA

Recommended Citation:
Yuan, Kai,Qin, Wei,Dong, Minghao,et al. Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals[J]. NEUROSCIENCE LETTERS,2010,482(2):101-105.
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