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学科主题: 临床医学
题名:
Chorangiocarcinoma: a case report and clinical review
作者: Huang, Bin; Zhang, Yan-Ping; Yuan, Dan-Fang; Yang, Rui; Wang, Chun; Wu, Rui-Fang
关键词: Chorangiocarcinoma ; placenta ; chorangioma ; trophoblastic disease ; choriocarcinoma
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
发表日期: 2015
卷: 8, 期:9, 页:16798-16802
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: INTRAPLACENTAL GESTATIONAL CHORIOCARCINOMA ; OF-THE-LITERATURE ; INFANTILE CHORIOCARCINOMA ; TERM PLACENTA ; CHORIOANGIOMA ; METASTASES ; PROLIFERATION ; POSTPARTUM ; PREGNANCY
英文摘要:

Objective: We describe a case of chorangiocarcinoma, a chorangioma covered by an abnormal trophoblastic proliferation, presenting in a term placenta and in an asymptomatic pregnancy. Evidence of metastasis was found on follow-up of the mother. Materials and methods: The lesion Was diagnosed by pathologic examination after cesarian section at term for fetal macrosomia, performed because of the abnormal gross findings in the placenta. After uncomplicated delivery, a thealthy child was born and the placent was expelled completely. There was follow-up in the mother and the child, up to 19 months after delivery. Results: Gross examination of the placenta showed a well-demarcated and grayish yellow-white mass, bulging paracentrally from the fetal surface. Histology revealed a trophoblastic proliferation inside a chorangioma, consisting of extensive central necrosis and high mitotic activity. Immunohistochemical staining showed strong intensity for hCG, PLAP, CK, CD31 (+) and CD34 (+); Ki67 showed a high proliferation index. Follow-up revealed metastasis in the mother and chemotherapy were performed at 3 months postpartum. Conclusion: This is only the sixth reported case of chorangiocarcinoma of the placenta in the literature. However, no metastasis were discovered in the reported case, which was not identical to ours. Followup revealed metastasis at lung in the mother. Chorangiocarcinoma should be carefully examined and followed-up.

语种: 英语
WOS记录号: WOS:000365273300162
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56473
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: Peking Univ, Shenzhen Hosp, Dept Obstet & Gynecol, Shenzhen 518036, Peoples R China

Recommended Citation:
Huang, Bin,Zhang, Yan-Ping,Yuan, Dan-Fang,et al. Chorangiocarcinoma: a case report and clinical review[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2015,8(9):16798-16802.
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