IR@PKUHSC  > 北京大学第一临床医学院  > 呼吸和危重症医学科
学科主题临床医学
Differential effects of cholesterol and budesonide on biophysical properties of clinical surfactant
Zhang, Hong1,2; Wang, Yi E.1; Neal, Charles R.3; Zuo, Yi Y.1
刊名PEDIATRIC RESEARCH
2012-04-01
DOI10.1038/pr.2011.78
71期:4页:316-323
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pediatrics
资助者Hawaii Community Foundation ; National Institutes of Health ; Peking University ; University of Hawaii at Manoa ; Hawaii Community Foundation ; National Institutes of Health ; Peking University ; University of Hawaii at Manoa
研究领域[WOS]Pediatrics
关键词[WOS]CHRONIC LUNG-DISEASE ; THERMOTROPIC PHASE-BEHAVIOR ; ATOMIC-FORCE MICROSCOPY ; PULMONARY SURFACTANT ; POSTNATAL CORTICOSTEROIDS ; BRONCHOPULMONARY DYSPLASIA ; INTRATRACHEAL INSTILLATION ; PREMATURE-INFANTS ; PRETERM INFANTS ; VEHICLE
英文摘要

INTRODUCTION: Corticosteroids have been widely used in clinical medicine as a first-line therapy to modify the inflammatory response in many pulmonary and systemic diseases. Inhaled and intratracheally administered corticosteroids have a particular interest in that their use allows the clinician to circumvent systemic steroid side effects. However, it is vital that corticosteroids delivered via the lungs not interfere with surface activity of the pulmonary surfactant lining layer.

RESULTS: We found differential effects of cholesterol and budesonide on the biophysical properties of a cholesterol-free clinical surfactant preparation, Curosurf. At a low concentration up to 1%, both steroids play a similar role of fluidizing the surfactant film. However, when steroid concentration is increased to 10%, cholesterol induces a unique phase transition that abolishes the surface activity of the Curosurf film. By contrast, 10% budesonide simply fluidizes the film, thus having only limited effects on surface activity.

DISCUSSION: Together with those of a previous study using a cholesterol-containing surfactant, our findings suggest that cholesterol-free surfactant preparations may be more advantageous than cholesterol-containing preparations as a carrier of budesonide because a larger amount of the drug may be delivered to the lungs without significantly compromising the surface activity of pulmonary surfactant.

METHODS: Langmuir balance was used to study the effect of cholesterol and budesonide added at different concentrations on surface activity of Curosurf. Atomic force microscopy (AFM) was used to reveal their effects on the interfacial molecular organization and lateral structure of Curosurf films.

语种英语
所属项目编号44936 ; US4RR026136
资助者Hawaii Community Foundation ; National Institutes of Health ; Peking University ; University of Hawaii at Manoa ; Hawaii Community Foundation ; National Institutes of Health ; Peking University ; University of Hawaii at Manoa
WOS记录号WOS:000301884500001
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56474
Collection北京大学第一临床医学院_呼吸和危重症医学科
作者单位1.Univ Hawaii Manoa, Dept Mech Engn, Honolulu, HI 96822 USA
2.Peking Univ, Dept Resp Med, Hosp 1, Beijing 100871, Peoples R China
3.Univ Hawaii Manoa, Dept Pediat, Honolulu, HI 96822 USA
Recommended Citation
GB/T 7714
Zhang, Hong,Wang, Yi E.,Neal, Charles R.,et al. Differential effects of cholesterol and budesonide on biophysical properties of clinical surfactant[J]. PEDIATRIC RESEARCH,2012,71(4):316-323.
APA Zhang, Hong,Wang, Yi E.,Neal, Charles R.,&Zuo, Yi Y..(2012).Differential effects of cholesterol and budesonide on biophysical properties of clinical surfactant.PEDIATRIC RESEARCH,71(4),316-323.
MLA Zhang, Hong,et al."Differential effects of cholesterol and budesonide on biophysical properties of clinical surfactant".PEDIATRIC RESEARCH 71.4(2012):316-323.
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