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学科主题临床医学
Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease
Jiang, Weiwei1; Wu, Na2; Wang, Xuemei1; Chi, Yujing2; Zhang, Yuanyuan1; Qiu, Xinyun1; Hu, Ying1; Li, Jing1; Liu, Yulan1
刊名SCIENTIFIC REPORTS
2015-02-03
DOI10.1038/srep08096
5
收录类别SCI
文章类型Editorial Material
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]BOWEL-DISEASE ; OBESE MICE ; IN-VIVO ; STEATOHEPATITIS ; IMPACT ; DIET ; PERMEABILITY ; LYMPHOCYTES ; APOPTOSIS ; DIAGNOSIS
英文摘要

Non-alcoholic fatty liver disease (NAFLD) has recently been considered to be under the influence of the gut microbiota, which might exert toxic effects on the human host after intestinal absorption and delivery to the liver via the portal vein. In this study, the composition of the gut microbiota in NAFLD patients and healthy subjects was determined via 16S ribosomal RNA Illumina next-generation sequencing. Among those taxa displaying greater than 0.1% average abundance in all samples, five genera, including Alistipes and Prevotella, were significantly more abundant in the gut microbiota of healthy subjects compared to NAFLD patients. Alternatively, Escherichia, Anaerobacter, Lactobacillus and Streptococcus were increased in the gut microbiota of NAFLD patients compared to healthy subjects. In addition, decreased numbers of CD4+ and CD8+ T lymphocytes and increased levels of TNF-alpha, IL-6 and IFN-gamma were detected in the NAFLD group compared to the healthy group. Furthermore, irregularly arranged microvilli and widened tight junctions were observed in the gut mucosa of the NAFLD patients via transmission electron microscopy. We postulate that aside from dysbiosis of the gut microbiota, gut microbiota-mediated inflammation of the intestinal mucosa and the related impairment in mucosal immune function play an important role in the pathogenesis of NAFLD.

语种英语
WOS记录号WOS:000348703000001
引用统计
被引频次:71[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56476
专题北京大学第二临床医学院_消化科
北京大学第二临床医学院_中心实验室
作者单位1.Peking Univ, Peoples Hosp, Dept Gastroenterol, Beijing 100871, Peoples R China
2.Peking Univ, Peoples Hosp, Inst Clin Mol Biol & Cent Lab, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Jiang, Weiwei,Wu, Na,Wang, Xuemei,et al. Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease[J]. SCIENTIFIC REPORTS,2015,5.
APA Jiang, Weiwei.,Wu, Na.,Wang, Xuemei.,Chi, Yujing.,Zhang, Yuanyuan.,...&Liu, Yulan.(2015).Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease.SCIENTIFIC REPORTS,5.
MLA Jiang, Weiwei,et al."Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease".SCIENTIFIC REPORTS 5(2015).
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