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The role of a proliferation-inducing ligand (APRIL) in the pathogenesis of rheumatoid arthritis
Zhao, J.; Guo, J.; Wang, L.; Zhou, W.; Zhang, Z.
刊名SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
2014
DOI10.3109/03009742.2014.905630
43期:6页:462-469
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]B-CELL ; DISEASE-ACTIVITY ; ANTIBODIES ; SYNOVITIS ; LYMPHOMA ; PROTEIN ; FAMILY ; BCMA
英文摘要

Objectives: To determine the differences in a proliferation-inducing ligand (APRIL) between seropositive and seronegative rheumatoid arthritis (RA) patients and further investigate the possible pathogenesis of the two subtypes of RA.

Method: Concentrations of APRIL in sera (18 seropositive RA patients, 16 seronegative RA patients, and 10 healthy controls) and synovial fluid (SF) (eight seropositive RA patients, two seronegative RA patients, and 10 controls) were detected by enzyme-linked immunosorbent assay (ELISA). Infiltration of plasma cells, macrophages, and APRIL-positive cells in the synovium [14 seropositives, eight seronegatives, and 10 osteoarthritis (OA) controls] was detected by immunohistochemistry. Correlations between serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), 28-joint Disease Activity Score (DAS28), and sera/SF levels of APRIL and synovial cell infiltration were analysed.

Results: The mean serum APRIL level of seropositive RA patients was significantly higher than that of seronegative patients (26.1 +/- 31.2 vs. 8.0 +/- 10.2 ng/mL, p = 0.03). The level of APRIL in the SF of seropositive RA patients was comparable to that of seronegative patients [47.9 +/- 54.4 vs. 32.82 (6.52-59.12) ng/mL, p > 0.05]. The SF APRIL level of RA patients was higher than that of patients with other inflammatory arthritis. Dramatically increased infiltration of APRIL-positive cells in the RA synovium was observed compared with the OA group (seropositive RA vs. OA, p < 0.001; seronegative RA vs. OA, p = 0.001). The infiltration of both plasma cells and macrophages was more in seropositive RA than in OA (p = 0.013 and p = 0.003, respectively).

Conclusions: The serum APRIL levels of seropositive RA patients are significantly higher than those of seronegative RA patients. APRIL may participate in the formation of seropositive RA.

语种英语
WOS记录号WOS:000345854600003
项目编号2010CB529103 ; 2010CB529103 ; Z080507030808022
资助机构&prime ; 973&prime ; subtopic of Science Support Project ; &prime ; 973&prime ; subtopic of Technology Support Project ; Beijing Municipal Science and Technology Commission
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56482
专题北京大学第一临床医学院
作者单位Peking Univ, Dept Rheumatol & Clin Immunol, Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhao, J.,Guo, J.,Wang, L.,et al. The role of a proliferation-inducing ligand (APRIL) in the pathogenesis of rheumatoid arthritis[J]. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY,2014,43(6):462-469.
APA Zhao, J.,Guo, J.,Wang, L.,Zhou, W.,&Zhang, Z..(2014).The role of a proliferation-inducing ligand (APRIL) in the pathogenesis of rheumatoid arthritis.SCANDINAVIAN JOURNAL OF RHEUMATOLOGY,43(6),462-469.
MLA Zhao, J.,et al."The role of a proliferation-inducing ligand (APRIL) in the pathogenesis of rheumatoid arthritis".SCANDINAVIAN JOURNAL OF RHEUMATOLOGY 43.6(2014):462-469.
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