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学科主题: 临床医学
题名:
The role of a proliferation-inducing ligand (APRIL) in the pathogenesis of rheumatoid arthritis
作者: Zhao, J.; Guo, J.; Wang, L.; Zhou, W.; Zhang, Z.
刊名: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
发表日期: 2014
DOI: 10.3109/03009742.2014.905630
卷: 43, 期:6, 页:462-469
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: B-CELL ; DISEASE-ACTIVITY ; ANTIBODIES ; SYNOVITIS ; LYMPHOMA ; PROTEIN ; FAMILY ; BCMA
英文摘要:

Objectives: To determine the differences in a proliferation-inducing ligand (APRIL) between seropositive and seronegative rheumatoid arthritis (RA) patients and further investigate the possible pathogenesis of the two subtypes of RA.

Method: Concentrations of APRIL in sera (18 seropositive RA patients, 16 seronegative RA patients, and 10 healthy controls) and synovial fluid (SF) (eight seropositive RA patients, two seronegative RA patients, and 10 controls) were detected by enzyme-linked immunosorbent assay (ELISA). Infiltration of plasma cells, macrophages, and APRIL-positive cells in the synovium [14 seropositives, eight seronegatives, and 10 osteoarthritis (OA) controls] was detected by immunohistochemistry. Correlations between serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), 28-joint Disease Activity Score (DAS28), and sera/SF levels of APRIL and synovial cell infiltration were analysed.

Results: The mean serum APRIL level of seropositive RA patients was significantly higher than that of seronegative patients (26.1 +/- 31.2 vs. 8.0 +/- 10.2 ng/mL, p = 0.03). The level of APRIL in the SF of seropositive RA patients was comparable to that of seronegative patients [47.9 +/- 54.4 vs. 32.82 (6.52-59.12) ng/mL, p > 0.05]. The SF APRIL level of RA patients was higher than that of patients with other inflammatory arthritis. Dramatically increased infiltration of APRIL-positive cells in the RA synovium was observed compared with the OA group (seropositive RA vs. OA, p < 0.001; seronegative RA vs. OA, p = 0.001). The infiltration of both plasma cells and macrophages was more in seropositive RA than in OA (p = 0.013 and p = 0.003, respectively).

Conclusions: The serum APRIL levels of seropositive RA patients are significantly higher than those of seronegative RA patients. APRIL may participate in the formation of seropositive RA.

语种: 英语
所属项目编号: 2010CB529103 ; 2010CB529103 ; Z080507030808022
项目资助者: &prime ; 973&prime ; subtopic of Science Support Project ; &prime ; 973&prime ; subtopic of Technology Support Project ; Beijing Municipal Science and Technology Commission
WOS记录号: WOS:000345854600003
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56482
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: Peking Univ, Dept Rheumatol & Clin Immunol, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Zhao, J.,Guo, J.,Wang, L.,et al. The role of a proliferation-inducing ligand (APRIL) in the pathogenesis of rheumatoid arthritis[J]. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY,2014,43(6):462-469.
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