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Autonomic mechanism for initiation of rapid firing from atria and pulmonary veins: evidence by ablation of ganglionated plexi
Lu, Zhibing2; Scherlag, Benjamin J.1; Lin, Jiaxiong3; Yu, Lilei2; Guo, Ji-Hong4; Niu, Guodong1; Jackman, Warren M.1; Lazzara, Ralph1; Jiang, Hong2; Po, Sunny S.1
关键词Atrial Fibrillation Ganglionated Plexus Autonomic Nervous System
刊名CARDIOVASCULAR RESEARCH
2009-11-01
DOI10.1093/cvr/cvp194
84期:2页:245-252
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]CARDIAC NERVOUS-SYSTEM ; IN-VITRO ; FIBRILLATION ; MARSHALL ; LIGAMENT ; STIMULATION ; INDUCIBILITY ; ELECTROGRAMS ; ARRHYTHMIA ; MODEL
英文摘要

Aims Previous studies showed that autonomic activation by high-frequency electrical stimulation (HFS) during myocardial refractoriness evokes rapid firing from pulmonary vein (PV) and atria, both in vitro and in vivo. This study sought to investigate the autonomic mechanism underlying the rapid firings at various sites by systematic ablation of multiple ganglionated plexi (GP).

Methods and results In 43 mongrel dogs, rapid firing-mediated atrial. fibrillation (AF) was induced by local HFS (200 Hz, impulse duration 0.1 ms, train duration 40 ms) to the PVs and atria during myocardial refractoriness. The main GP in the atrial fat pads or the ganglia along the ligament of Marshall (LCM) were then ablated. Ablation of the anterior right GP and inferior right GP significantly increased the AF threshold by HFS at the right atrium and PVs. The AF threshold at left atrium and PVs was significantly increased by ablation of the superior left GP and inferior left GP, and was further increased by ablation of the LOM. Ablation of left- or right-sided GP on the atria had a significant effect on contralateral PVs and atrium. Administration of esmolol (1 mg/kg) or atropine (1 mg) significantly increased AF threshold at all sites.

Conclusion HFS applied to local atrial and PV sites initiated rapid firing via activation of the interactive autonomic network in the heart. GP in either left side or right side contributes to the rapid firings and AF originating from ipsolateral and contralateral PVs and atrium. Autonomic denervation suppresses or eliminates those rapid firings.

语种英语
WOS记录号WOS:000271422900012
项目编号0650077Z ; K23HL069972 ; 30700313 ; 200750730309
资助机构American Heart Association ; National Heart, Lung and Blood Institute ; University of Oklahoma Foundation ; National Natural Science Foundation of China ; Wuhan City, China
引用统计
被引频次:67[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56485
专题北京大学第二临床医学院
北京大学临床肿瘤学院_药剂科
作者单位1.Univ Oklahoma, Hlth Sci Ctr, Heart Rhythm Inst, Oklahoma City, OK 73104 USA
2.Wuhan Univ, Dept Cardiol, Renmin Hosp, Wuhan 430072, Peoples R China
3.Fudan Univ, Zhongshan Hosp, Dept Cardiol, Shanghai 200433, Peoples R China
4.Peking Univ, Dept Cardiac Electrophysiol, Peoples Hosp, Beijing 100871, Peoples R China
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GB/T 7714
Lu, Zhibing,Scherlag, Benjamin J.,Lin, Jiaxiong,et al. Autonomic mechanism for initiation of rapid firing from atria and pulmonary veins: evidence by ablation of ganglionated plexi[J]. CARDIOVASCULAR RESEARCH,2009,84(2):245-252.
APA Lu, Zhibing.,Scherlag, Benjamin J..,Lin, Jiaxiong.,Yu, Lilei.,Guo, Ji-Hong.,...&Po, Sunny S..(2009).Autonomic mechanism for initiation of rapid firing from atria and pulmonary veins: evidence by ablation of ganglionated plexi.CARDIOVASCULAR RESEARCH,84(2),245-252.
MLA Lu, Zhibing,et al."Autonomic mechanism for initiation of rapid firing from atria and pulmonary veins: evidence by ablation of ganglionated plexi".CARDIOVASCULAR RESEARCH 84.2(2009):245-252.
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