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学科主题: 临床医学
题名:
Autonomic mechanism for initiation of rapid firing from atria and pulmonary veins: evidence by ablation of ganglionated plexi
作者: Lu, Zhibing2; Scherlag, Benjamin J.1; Lin, Jiaxiong3; Yu, Lilei2; Guo, Ji-Hong4; Niu, Guodong1; Jackman, Warren M.1; Lazzara, Ralph1; Jiang, Hong2; Po, Sunny S.1
关键词: Atrial fibrillation ; Ganglionated plexus ; Autonomic nervous system
刊名: CARDIOVASCULAR RESEARCH
发表日期: 2009-11-01
DOI: 10.1093/cvr/cvp194
卷: 84, 期:2, 页:245-252
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: CARDIAC NERVOUS-SYSTEM ; IN-VITRO ; FIBRILLATION ; MARSHALL ; LIGAMENT ; STIMULATION ; INDUCIBILITY ; ELECTROGRAMS ; ARRHYTHMIA ; MODEL
英文摘要:

Aims Previous studies showed that autonomic activation by high-frequency electrical stimulation (HFS) during myocardial refractoriness evokes rapid firing from pulmonary vein (PV) and atria, both in vitro and in vivo. This study sought to investigate the autonomic mechanism underlying the rapid firings at various sites by systematic ablation of multiple ganglionated plexi (GP).

Methods and results In 43 mongrel dogs, rapid firing-mediated atrial. fibrillation (AF) was induced by local HFS (200 Hz, impulse duration 0.1 ms, train duration 40 ms) to the PVs and atria during myocardial refractoriness. The main GP in the atrial fat pads or the ganglia along the ligament of Marshall (LCM) were then ablated. Ablation of the anterior right GP and inferior right GP significantly increased the AF threshold by HFS at the right atrium and PVs. The AF threshold at left atrium and PVs was significantly increased by ablation of the superior left GP and inferior left GP, and was further increased by ablation of the LOM. Ablation of left- or right-sided GP on the atria had a significant effect on contralateral PVs and atrium. Administration of esmolol (1 mg/kg) or atropine (1 mg) significantly increased AF threshold at all sites.

Conclusion HFS applied to local atrial and PV sites initiated rapid firing via activation of the interactive autonomic network in the heart. GP in either left side or right side contributes to the rapid firings and AF originating from ipsolateral and contralateral PVs and atrium. Autonomic denervation suppresses or eliminates those rapid firings.

语种: 英语
所属项目编号: 0650077Z ; K23HL069972 ; 30700313 ; 200750730309
项目资助者: American Heart Association ; National Heart, Lung and Blood Institute ; University of Oklahoma Foundation ; National Natural Science Foundation of China ; Wuhan City, China
WOS记录号: WOS:000271422900012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56485
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Univ Oklahoma, Hlth Sci Ctr, Heart Rhythm Inst, Oklahoma City, OK 73104 USA
2.Wuhan Univ, Dept Cardiol, Renmin Hosp, Wuhan 430072, Peoples R China
3.Fudan Univ, Zhongshan Hosp, Dept Cardiol, Shanghai 200433, Peoples R China
4.Peking Univ, Dept Cardiac Electrophysiol, Peoples Hosp, Beijing 100871, Peoples R China

Recommended Citation:
Lu, Zhibing,Scherlag, Benjamin J.,Lin, Jiaxiong,et al. Autonomic mechanism for initiation of rapid firing from atria and pulmonary veins: evidence by ablation of ganglionated plexi[J]. CARDIOVASCULAR RESEARCH,2009,84(2):245-252.
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