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学科主题: 药学
题名:
Galactosylated bovine serum albumin nanoparticles for parenteral delivery of oridonin: tissue distribution and pharmacokinetic studies
作者: Li, Caiyun1; Zhang, Dianrui1; Guo, Yuanyuan1; Guo, Hejian1; Li, Tingting1; Hao, Leilei1; Zheng, Dandan1; Liu, Guangpu1; Zhang, Qiang2
关键词: Bovine serum albumin nanoparticles ; galactosylated ; oridonin ; pharmacokinetics ; tissue distribution
刊名: JOURNAL OF MICROENCAPSULATION
发表日期: 2014
DOI: 10.3109/02652048.2014.898705
卷: 31, 期:6, 页:573-578
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Applied ; Engineering, Chemical ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Engineering ; Pharmacology & Pharmacy
关键词[WOS]: TARGETED DELIVERY ; IN-VITRO ; PACLITAXEL ; BIODISTRIBUTION ; FORMULATION ; CHITOSAN ; CARRIER
英文摘要:

Bovine serum albumin (BSA) nanoparticle is a promising drug carrier system. Oridonin (ORI)-loaded galactosylated BSA nanoparticle (ORI-GB-NP) was prepared for liver targeting delivery of ORI. This work was designed to investigate the in vitro release, in vivo pharmacokinetics and tissue distribution of ORI-GB-NP. ORI-GB-NP was prepared by the desolvation method. The particle size of ORI-GB-NP was 172.0 +/- 8.3 nm with narrow size distribution. The in vitro release of ORI-GB-NP exhibited biphasic drug release pattern with an initial burst release and consequently sustained release. Pharmacokinetic analysis displayed that ORI-GB-NP and ORI-loaded BSA nanoparticle (ORI-BSA-NP) could enhance the drug plasma level and prolong the circulation time in contrast with ORI solution. Meanwhile, compared with ORI-BSA-NP, ORI-GB-NP could deliver more ORI to liver and simultaneously reduce the toxicity of ORI to heart, lung and kidney. In conclusion, ORI-GB-NP could be a promising drug delivery system for liver cancer therapy.

语种: 英语
项目资助者: National Basic Research Programme of China (973 Programme)
WOS记录号: WOS:000340892600008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56488
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shandong Univ, Coll Pharm, Dept Pharmaceut, Jinan 250100, Shandong, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China

Recommended Citation:
Li, Caiyun,Zhang, Dianrui,Guo, Yuanyuan,et al. Galactosylated bovine serum albumin nanoparticles for parenteral delivery of oridonin: tissue distribution and pharmacokinetic studies[J]. JOURNAL OF MICROENCAPSULATION,2014,31(6):573-578.
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