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Galactosylated bovine serum albumin nanoparticles for parenteral delivery of oridonin: tissue distribution and pharmacokinetic studies
Li, Caiyun1; Zhang, Dianrui1; Guo, Yuanyuan1; Guo, Hejian1; Li, Tingting1; Hao, Leilei1; Zheng, Dandan1; Liu, Guangpu1; Zhang, Qiang2
关键词Bovine Serum Albumin Nanoparticles Galactosylated Oridonin Pharmacokinetics Tissue Distribution
刊名JOURNAL OF MICROENCAPSULATION
2014
DOI10.3109/02652048.2014.898705
31期:6页:573-578
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied ; Engineering, Chemical ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Engineering ; Pharmacology & Pharmacy
关键词[WOS]TARGETED DELIVERY ; IN-VITRO ; PACLITAXEL ; BIODISTRIBUTION ; FORMULATION ; CHITOSAN ; CARRIER
英文摘要

Bovine serum albumin (BSA) nanoparticle is a promising drug carrier system. Oridonin (ORI)-loaded galactosylated BSA nanoparticle (ORI-GB-NP) was prepared for liver targeting delivery of ORI. This work was designed to investigate the in vitro release, in vivo pharmacokinetics and tissue distribution of ORI-GB-NP. ORI-GB-NP was prepared by the desolvation method. The particle size of ORI-GB-NP was 172.0 +/- 8.3 nm with narrow size distribution. The in vitro release of ORI-GB-NP exhibited biphasic drug release pattern with an initial burst release and consequently sustained release. Pharmacokinetic analysis displayed that ORI-GB-NP and ORI-loaded BSA nanoparticle (ORI-BSA-NP) could enhance the drug plasma level and prolong the circulation time in contrast with ORI solution. Meanwhile, compared with ORI-BSA-NP, ORI-GB-NP could deliver more ORI to liver and simultaneously reduce the toxicity of ORI to heart, lung and kidney. In conclusion, ORI-GB-NP could be a promising drug delivery system for liver cancer therapy.

语种英语
WOS记录号WOS:000340892600008
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56488
专题北京大学药学院
北京大学药学院_药剂学系
作者单位1.Shandong Univ, Coll Pharm, Dept Pharmaceut, Jinan 250100, Shandong, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Li, Caiyun,Zhang, Dianrui,Guo, Yuanyuan,et al. Galactosylated bovine serum albumin nanoparticles for parenteral delivery of oridonin: tissue distribution and pharmacokinetic studies[J]. JOURNAL OF MICROENCAPSULATION,2014,31(6):573-578.
APA Li, Caiyun.,Zhang, Dianrui.,Guo, Yuanyuan.,Guo, Hejian.,Li, Tingting.,...&Zhang, Qiang.(2014).Galactosylated bovine serum albumin nanoparticles for parenteral delivery of oridonin: tissue distribution and pharmacokinetic studies.JOURNAL OF MICROENCAPSULATION,31(6),573-578.
MLA Li, Caiyun,et al."Galactosylated bovine serum albumin nanoparticles for parenteral delivery of oridonin: tissue distribution and pharmacokinetic studies".JOURNAL OF MICROENCAPSULATION 31.6(2014):573-578.
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