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学科主题: 临床医学
题名:
An investigation of (125)vertical bar seed permanent implantation for recurrent carcinoma in the head and neck after surgery and external beam radiotherapy
作者: Zhu, Lihong1; Jiang, Yuliang1; Wang, Junjie1; Ran, Weiqiang2; Yuan, Huishu3; Liu, Chen3; Qu, Ang1; Yang, Ruijie1
关键词: (125)vertical bar seed ; Head and neck carcinoma ; Surgery ; External beam radiotherapy
刊名: WORLD JOURNAL OF SURGICAL ONCOLOGY
发表日期: 2013-03-08
DOI: 10.1186/1477-7819-11-60
卷: 11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Surgery
研究领域[WOS]: Oncology ; Surgery
关键词[WOS]: SQUAMOUS-CELL CANCER ; RADIATION-THERAPY ; CAROTID-ARTERY ; I125 IMPLANTS ; REIRRADIATION ; TONGUE ; 5-FLUOROURACIL ; BRACHYTHERAPY ; NASOPHARYNX ; IRRADIATION
英文摘要:

Background: A preliminary assessment was conducted of the feasibility, efficacy, and morbidity of (125)vertical bar seed implantation for recurrent head and neck carcinoma after surgery and external beam radiotherapy.

Methods: Nineteen patients with recurrent head and neck carcinomas underwent (125)vertical bar seed implantation under ultrasound or computed tomography guidance. The actuarial D90 of (125)vertical bar seed implantation ranged from 90 to 160 Gy (median, 131 Gy). The follow-up period ranged from 3 to 44 months (median, 11 months).

Results: The median local control was 24 months (95% confidence interval, 10.2 to 37.8). The one- year, two-year and three-year local controls were 73.3%, 27.5% and 27.5%, respectively, whereas the one-year, two-year and three-year survival rates were 53.0%, 18.2% and 18.2%, respectively, and the median survival was 13 months (95% confidence interval, 6.6 to 19.4). A total of 26.3% of patients (5/19) died of local recurrence and 21.1% of patients (4/19) died of metastases. One suffered from a grade 1 skin reaction.

Conclusions: (125)vertical bar seed implantation is feasible and safe as a salvage treatment for patients with recurrent head and neck cancers. The high local control results and low morbidity merits further investigation.

语种: 英语
项目资助者: Capital Medical Development Grant of Beijing
WOS记录号: WOS:000316764700001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56494
Appears in Collections:北京大学第三临床医学院_肿瘤放疗科_期刊论文

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作者单位: 1.Peking Univ, Dept Radiat Oncol, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Dept Ultrasound, Hosp 3, Beijing 100191, Peoples R China
3.Peking Univ, Dept Radiol, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
Zhu, Lihong,Jiang, Yuliang,Wang, Junjie,et al. An investigation of (125)vertical bar seed permanent implantation for recurrent carcinoma in the head and neck after surgery and external beam radiotherapy[J]. WORLD JOURNAL OF SURGICAL ONCOLOGY,2013,11.
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