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学科主题: 口腔医学
题名:
Role of ferritin in the cytodifferentiation of periodontal ligament cells
作者: Hou, Jianxia1,2; Yamada, Satoru1; Kajikawa, Tetsuhiro1; Ozaki, Nobuhiro1; Awata, Toshihito1; Yamaba, Satoko1; Murakami, Shinya1
关键词: Periodontal ligament ; Ferritin ; Osteogenesis ; Cementogenesis
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2012-10-05
DOI: 10.1016/j.bbrc.2012.09.008
卷: 426, 期:4, 页:643-648
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: STEM-CELLS ; EXPRESSION ; GENES ; IRON ; OSTEOGENESIS
英文摘要:

This study investigated the expression and functions of ferritin, which is involved in osteoblastogenesis, in the periodontal ligament (PDL). The PDL is one of the most important tissues for maintaining the homeostasis of teeth and tooth-supporting tissues. Real-time PCR analyses of the human PDL revealed abundant expression of Puffin light polypeptide (FTL) and ferritin heavy polypeptide (FTH), which encode the highly-conserved iron storage protein, ferritin. Immunohistochemical staining demonstrated predominant expression of FTL and FTH in mouse PDL tissues in vivo. In in vitro-maintained mouse PDL cells, FTL and FTH expressions were upregulated at both the mRNA and protein levels during the course of cytodifferentiation and mineralization. Interestingly, stimulation of PDL cells with exogenous apoferritin (iron-free ferritin) increased calcified nodule formation and alkaline phosphatase activity as well as the mRNA expressions of mineralization-related genes during the course of cytodifferentiation. On the other hand, RNA interference of FTH inhibited the mineralized nodule formation of PDL cells. This is the first report to demonstrate that ferritin is predominantly expressed in PDL tissues and positively regulates the cytodifferentiation and mineralization of PDL cells. (C) 2012 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 23249086 ; 23390478
项目资助者: Japan Society for the Promotion of Science ; China Scholarship Council (CSC)
WOS记录号: WOS:000310101000034
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56495
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Osaka Univ, Dept Periodontol, Grad Sch Dent, Suita, Osaka 5650871, Japan
2.Peking Univ, Sch & Hosp Stomatol, Dept Periodontol, Beijing 100081, Peoples R China

Recommended Citation:
Hou, Jianxia,Yamada, Satoru,Kajikawa, Tetsuhiro,et al. Role of ferritin in the cytodifferentiation of periodontal ligament cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2012,426(4):643-648.
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