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Liquid chromatography/electrospray ionization mass spectrometry for the characterization of twenty-three flavonoids in the extract of Dalbergia odorifera
Liu, RX; Ye, M; Guo, HZ; Bi, KS; Guo, DA
刊名RAPID COMMUNICATIONS IN MASS SPECTROMETRY
2005
DOI10.1002/rcm.1936
19期:11页:1557-1565
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical ; Spectroscopy
研究领域[WOS]Chemistry ; Spectroscopy
关键词[WOS]PHOTODIODE-ARRAY ; PHENOLIC-COMPOUNDS ; RED-CLOVER ; IDENTIFICATION ; CONSTITUENTS ; ISOFLAVONES ; ULTRAVIOLET ; GLYCOSIDES ; BUTEIN ; HERB
英文摘要

A method incorporating high-performance liquid chromatography (HPLC) with electrospray ionization and tandem mass spectrometry, with parallel analysis by HPLC with UV detection using a diode-array detector, was developed for the qualitative characterization of flavonoids in D. odorifera. Twenty-three flavonoids, including six isoflavones, six neoflavones, four isoflavanones, three flavanones, two chalcones, one isoflavanonol and one pterocarpan, were unambiguously identified by comparing their retention times, UV and NIS spectra with those of authentic compounds. Furthermore, the collision-induced dissociations of the [M-H](-) ions were studied to clarify the MS behavior of the different types of flavonoids. In negative ion ESI-MS all the flavonoids yielded prominent [M-H](-) ions in the first order mass spectra. Fragments involving losses of CH3, H2O, CO, C2H2O, and CO2 were observed in the MS/MS spectra. Each of the seven types of flavonoid showed characteristic MS/MS fragmentation patterns. The isoflavanones, flavanones and chalcones were observed to undergo retro-Diels-Alder fragmentations. The spectra of almost all the neoflavonoids unexpectedly exhibited only [M-H-CH3](-) radical anions as base peaks without any further fragmentation. Substitution positions also remarkably influenced the fragmentation behavior, which could assist in distinction among the flavonoid isomers. The fragmentation rules deduced here could aid in the characterization of other flavonoids of these types. Copyright © 2005 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000229518600026
引用统计
被引频次:68[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56512
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Shenyang Pharmaceut Unit, Shenyang 110016, Peoples R China
推荐引用方式
GB/T 7714
Liu, RX,Ye, M,Guo, HZ,et al. Liquid chromatography/electrospray ionization mass spectrometry for the characterization of twenty-three flavonoids in the extract of Dalbergia odorifera[J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY,2005,19(11):1557-1565.
APA Liu, RX,Ye, M,Guo, HZ,Bi, KS,&Guo, DA.(2005).Liquid chromatography/electrospray ionization mass spectrometry for the characterization of twenty-three flavonoids in the extract of Dalbergia odorifera.RAPID COMMUNICATIONS IN MASS SPECTROMETRY,19(11),1557-1565.
MLA Liu, RX,et al."Liquid chromatography/electrospray ionization mass spectrometry for the characterization of twenty-three flavonoids in the extract of Dalbergia odorifera".RAPID COMMUNICATIONS IN MASS SPECTROMETRY 19.11(2005):1557-1565.
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