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学科主题临床医学
Anti-glomerular basement membrane autoantibodies against different target antigens are associated with disease severity
Zhao, Juan; Cui, Zhao; Yang, Rui; Jia, Xiao-yu; Zhang, Ying; Zhao, Ming-hui
关键词Anti-gbm Autoantibodies Anti-gbm Disease Epitope Spreading Goodpasture Renal Function
刊名KIDNEY INTERNATIONAL
2009-11-01
DOI10.1038/ki.2009.348
76期:10页:1108-1115
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]NORMAL RENAL-FUNCTION ; NORMAL HUMAN SERA ; T-CELL EPITOPE ; IV COLLAGEN ; GOODPASTURES-SYNDROME ; AUTOIMMUNE GLOMERULONEPHRITIS ; GBM ANTIBODIES ; ALPHA-3 CHAIN ; IDENTIFICATION ; SPECIFICITY
英文摘要

Anti-glomerular basement membrane (GBM) autoantibodies are pathogenic in the development of anti-GBM disease. The main target antigen is the non-collagenous 1 domain (NC1) of collagen alpha 3(IV); however, most antibodies can recognize the NC1 of collagens alpha 1, alpha 2, alpha 4 and alpha 5(IV). In this study, we analyzed the target antigens of anti-GBM autoantibodies to determine their relationship to the severity of renal damage. Natural anti-GBM autoantibodies were purified from 10 healthy individuals and from 57 patients with anti-GBM disease who were divided into groups based on the degree of renal damage defined by their serum creatinine at the time of diagnosis. We found that the sera of all 57 patients recognized alpha 3(IV) NC1, while 23, 20, 28, and 48 patients also recognized the NC1 of collagens alpha 1, alpha 2, alpha 4, and alpha 5(IV), respectively. Natural anti-GBM autoantibodies recognized the NC1 of collagens alpha 3 and alpha 4(IV). The sera of 7 patients with the lowest level of renal damage mainly recognized the NC1 of collagens alpha 3 and alpha 5(IV). In the 20 patients with moderate and the 30 with severe renal damage, all five target antigens could be detected and most sera recognized three to five different alpha chains simultaneously. Regression analysis showed that only the level of autoantibodies against the NC1 of collagen alpha 3(IV) was a significant independent risk factor for higher serum creatinine on diagnosis. Our study shows that autoantibodies to the NC1 of collagen alpha 3(IV) were crucial in causing renal damage. Inter-and intra-molecular epitope spreading can occur during the development of human anti-GBM disease. Kidney International (2009) 76, 1108-1115; doi: 10.1038/ki.2009.348; published online 9 September 2009

语种英语
WOS记录号WOS:000271383000013
项目编号30700752 ; 30725034
资助机构National Natural Science Foundation of China
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被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56513
专题北京大学第一临床医学院_肾脏内科
作者单位Peking Univ, Div Renal, Dept Med,Hosp 1, Inst Nephrol,Key Lab Renal Dis,Minist Hlth China, Beijing 100034, Peoples R China
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Zhao, Juan,Cui, Zhao,Yang, Rui,et al. Anti-glomerular basement membrane autoantibodies against different target antigens are associated with disease severity[J]. KIDNEY INTERNATIONAL,2009,76(10):1108-1115.
APA Zhao, Juan,Cui, Zhao,Yang, Rui,Jia, Xiao-yu,Zhang, Ying,&Zhao, Ming-hui.(2009).Anti-glomerular basement membrane autoantibodies against different target antigens are associated with disease severity.KIDNEY INTERNATIONAL,76(10),1108-1115.
MLA Zhao, Juan,et al."Anti-glomerular basement membrane autoantibodies against different target antigens are associated with disease severity".KIDNEY INTERNATIONAL 76.10(2009):1108-1115.
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