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学科主题: 药学
题名:
Quadrupole time-of-flight mass spectrometry as a powerful tool for demystifying traditional Chinese medicine
作者: Zhang, Zhengxiang1; Bo, Tao1; Bai, Yu2; Ye, Min3; An, Rong1; Cheng, Fafeng4; Liu, Huwei2
关键词: Active ingredient ; Intervention effect ; Metabolomics ; Quadrupole time-of-flight mass spectrometry ; Quality control ; Screening ; Toxicity ; Traditional Chinese medicine
刊名: TRAC-TRENDS IN ANALYTICAL CHEMISTRY
发表日期: 2015-10-01
DOI: 10.1016/j.trac.2015.04.021
卷: 72, 页:169-180
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
关键词[WOS]: Q-TOF-MS/MS ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; ISOTOPIC ABUNDANCE MEASUREMENTS ; ACID-INDUCED NEPHROTOXICITY ; DATA-PROCESSING TECHNIQUES ; GYNOSTEMMA-PENTAPHYLLUM ; ACCURATE-MASS ; METABOLITE IDENTIFICATION ; ARISTOLOCHIC ACID ; RAPID CHARACTERIZATION
英文摘要:

Traditional Chinese medicine (TCM) has been effective in prevention and treatment of chronic diseases in a synergic manner with mild healing effects and lower side effects than Western medicines. Researchers have made great efforts to explore the real theory of TCM for many years with different strategies. With the rapid advances in instrumentation in chromatography and mass spectrometry, more scientific outcomes have been achieved for disclosing the mysteries of TCM. In this article, we review the achievements of quadrupole time-of-flight mass spectrometry in TCM analysis, including profiling active ingredients and their metabolites, screening harmful components, and applying cutting-edge metabolomics strategies. (C) 2015 Elsevier B.V All rights reserved.

语种: 英语
所属项目编号: 21275012 ; 2013YQ510391 ; 2012YQ090194-9
项目资助者: National Natural Science Foundation of China ; Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000363819900024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56514
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Agilent Technol China Co Ltd, Beijing 100102, Peoples R China
2.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
4.Beijing Univ Chinese Med, Sch Basic Med Sci, Beijing 100029, Peoples R China

Recommended Citation:
Zhang, Zhengxiang,Bo, Tao,Bai, Yu,et al. Quadrupole time-of-flight mass spectrometry as a powerful tool for demystifying traditional Chinese medicine[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2015,72:169-180.
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