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Quadrupole time-of-flight mass spectrometry as a powerful tool for demystifying traditional Chinese medicine
Zhang, Zhengxiang1; Bo, Tao1; Bai, Yu2; Ye, Min3; An, Rong1; Cheng, Fafeng4; Liu, Huwei2
关键词Active Ingredient Intervention Effect Metabolomics Quadrupole Time-of-flight Mass Spectrometry Quality Control Screening Toxicity Traditional Chinese Medicine
刊名TRAC-TRENDS IN ANALYTICAL CHEMISTRY
2015-10-01
DOI10.1016/j.trac.2015.04.021
72页:169-180
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]Q-TOF-MS/MS ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; ISOTOPIC ABUNDANCE MEASUREMENTS ; ACID-INDUCED NEPHROTOXICITY ; DATA-PROCESSING TECHNIQUES ; GYNOSTEMMA-PENTAPHYLLUM ; ACCURATE-MASS ; METABOLITE IDENTIFICATION ; ARISTOLOCHIC ACID ; RAPID CHARACTERIZATION
英文摘要

Traditional Chinese medicine (TCM) has been effective in prevention and treatment of chronic diseases in a synergic manner with mild healing effects and lower side effects than Western medicines. Researchers have made great efforts to explore the real theory of TCM for many years with different strategies. With the rapid advances in instrumentation in chromatography and mass spectrometry, more scientific outcomes have been achieved for disclosing the mysteries of TCM. In this article, we review the achievements of quadrupole time-of-flight mass spectrometry in TCM analysis, including profiling active ingredients and their metabolites, screening harmful components, and applying cutting-edge metabolomics strategies. (C) 2015 Elsevier B.V All rights reserved.

语种英语
WOS记录号WOS:000363819900024
项目编号21275012 ; 2013YQ510391 ; 2012YQ090194-9
资助机构National Natural Science Foundation of China ; Ministry of Science and Technology of the People&prime ; s Republic of China
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56514
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位1.Agilent Technol China Co Ltd, Beijing 100102, Peoples R China
2.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
4.Beijing Univ Chinese Med, Sch Basic Med Sci, Beijing 100029, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Zhengxiang,Bo, Tao,Bai, Yu,et al. Quadrupole time-of-flight mass spectrometry as a powerful tool for demystifying traditional Chinese medicine[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2015,72:169-180.
APA Zhang, Zhengxiang.,Bo, Tao.,Bai, Yu.,Ye, Min.,An, Rong.,...&Liu, Huwei.(2015).Quadrupole time-of-flight mass spectrometry as a powerful tool for demystifying traditional Chinese medicine.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,72,169-180.
MLA Zhang, Zhengxiang,et al."Quadrupole time-of-flight mass spectrometry as a powerful tool for demystifying traditional Chinese medicine".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 72(2015):169-180.
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