学科主题基础医学
Hepatitis E virus genotype 4 isolated from a patient with liver failure: full-length sequence analysis showing potential determinants of virus pathogenesis
Bu, Qiuning1,2; Wang, Xiaojuan1; Wang, Ling1; Liu, Peng1; Geng, Jiabao3; Wang, Maorong3; Han, Jian1; Zhu, Yonghong1; Zhuang, Hui1
刊名ARCHIVES OF VIROLOGY
2013
DOI10.1007/s00705-012-1488-3
158期:1页:165-172
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Virology
研究领域[WOS]Virology
关键词[WOS]HEV INFECTION ; TRANSPLANT RECIPIENTS ; ZOONOTIC TRANSMISSION ; DISEASE ; CHINA ; SWINE ; FULMINANT ; DECOMPENSATION ; SUPERINFECTION ; FRANCE
英文摘要

The full-length genome sequence of a genotype 4 strain of Hepatitis E virus (HEV) (CHN-NJ-H2011) from a patient (in Nanjing, China) with liver failure has been determined. Phylogenetic analysis showed that CHN-NJ-H2011 belongs to genotype 4, subtype 4h. Comparative sequence analysis carried out on a 301-bp fragment of ORF2 showed that CHN-NJ-H2011 shares high nucleotide sequence identity (94.3-94.7 %) with porcine viruses (ch-shsw1 and Ch-estw2) isolated in the same geographical region, pointing to the strong possibility of zoonotic transmission of HEV genotype 4. A broader comparison with other genotype 4 isolates revealed 12 unique amino acid substitutions in ORF1 and three in ORF2 that might serve as signatures of disease severity for genotype 4 HEV infection.

语种英语
WOS记录号WOS:000313294200018
项目编号81271827
资助机构National Science Foundation of China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56516
专题北京大学基础医学院_北京大学感染病研究中心
作者单位1.81st Hosp PLA, Inst Hepatol, Nanjing, Jiangsu, Peoples R China
2.Peking Univ, Ctr Infect Dis, Dept Microbiol, Sch Basic Med Sci, Beijing 100191, Peoples R China
3.First Hosp Qinhuangdao, Clin Lab, Qinhuangdao, Hebei Province, Peoples R China
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GB/T 7714
Bu, Qiuning,Wang, Xiaojuan,Wang, Ling,et al. Hepatitis E virus genotype 4 isolated from a patient with liver failure: full-length sequence analysis showing potential determinants of virus pathogenesis[J]. ARCHIVES OF VIROLOGY,2013,158(1):165-172.
APA Bu, Qiuning.,Wang, Xiaojuan.,Wang, Ling.,Liu, Peng.,Geng, Jiabao.,...&Zhuang, Hui.(2013).Hepatitis E virus genotype 4 isolated from a patient with liver failure: full-length sequence analysis showing potential determinants of virus pathogenesis.ARCHIVES OF VIROLOGY,158(1),165-172.
MLA Bu, Qiuning,et al."Hepatitis E virus genotype 4 isolated from a patient with liver failure: full-length sequence analysis showing potential determinants of virus pathogenesis".ARCHIVES OF VIROLOGY 158.1(2013):165-172.
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