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学科主题: 基础医学
题名:
Hepatitis E virus genotype 4 isolated from a patient with liver failure: full-length sequence analysis showing potential determinants of virus pathogenesis
作者: Bu, Qiuning1,2; Wang, Xiaojuan1; Wang, Ling1; Liu, Peng1; Geng, Jiabao3; Wang, Maorong3; Han, Jian1; Zhu, Yonghong1; Zhuang, Hui1
刊名: ARCHIVES OF VIROLOGY
发表日期: 2013
DOI: 10.1007/s00705-012-1488-3
卷: 158, 期:1, 页:165-172
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Virology
研究领域[WOS]: Virology
关键词[WOS]: HEV INFECTION ; TRANSPLANT RECIPIENTS ; ZOONOTIC TRANSMISSION ; DISEASE ; CHINA ; SWINE ; FULMINANT ; DECOMPENSATION ; SUPERINFECTION ; FRANCE
英文摘要:

The full-length genome sequence of a genotype 4 strain of Hepatitis E virus (HEV) (CHN-NJ-H2011) from a patient (in Nanjing, China) with liver failure has been determined. Phylogenetic analysis showed that CHN-NJ-H2011 belongs to genotype 4, subtype 4h. Comparative sequence analysis carried out on a 301-bp fragment of ORF2 showed that CHN-NJ-H2011 shares high nucleotide sequence identity (94.3-94.7 %) with porcine viruses (ch-shsw1 and Ch-estw2) isolated in the same geographical region, pointing to the strong possibility of zoonotic transmission of HEV genotype 4. A broader comparison with other genotype 4 isolates revealed 12 unique amino acid substitutions in ORF1 and three in ORF2 that might serve as signatures of disease severity for genotype 4 HEV infection.

语种: 英语
所属项目编号: 81271827
项目资助者: National Science Foundation of China
WOS记录号: WOS:000313294200018
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56516
Appears in Collections:基础医学院_北京大学感染病研究中心_期刊论文

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Hepatitis E vaccine immunization for rabbits to prevent animal HEV infection and zoonotic transmission.pdf(1349KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.81st Hosp PLA, Inst Hepatol, Nanjing, Jiangsu, Peoples R China
2.Peking Univ, Ctr Infect Dis, Dept Microbiol, Sch Basic Med Sci, Beijing 100191, Peoples R China
3.First Hosp Qinhuangdao, Clin Lab, Qinhuangdao, Hebei Province, Peoples R China

Recommended Citation:
Bu, Qiuning,Wang, Xiaojuan,Wang, Ling,et al. Hepatitis E virus genotype 4 isolated from a patient with liver failure: full-length sequence analysis showing potential determinants of virus pathogenesis[J]. ARCHIVES OF VIROLOGY,2013,158(1):165-172.
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