IR@PKUHSC  > 北京大学口腔医学院  > 儿童口腔科
学科主题口腔医学
PAX6 polymorphisms in 20 Chinese children with supernumerary teeth in the maxillary incisor area
Lei, Hai-Hua; Liu, He; Ge, Li-Hong
刊名INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
2011-07-01
DOI10.1111/j.1365-263X.2011.01119.x
21期:4页:271-277
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine ; Pediatrics
资助者Specialized Research Fund for the Doctoral Program of Higher Education of China ; Specialized Research Fund for the Doctoral Program of Higher Education of China
研究领域[WOS]Dentistry, Oral Surgery & Medicine ; Pediatrics
关键词[WOS]CRANIOFACIAL ABNORMALITIES ; CLEIDOCRANIAL DYSPLASIA ; ANIRIDIA ; GENE ; MUTATIONS ; ASSOCIATION ; PATIENT ; MICE ; APC
英文摘要

Aim.

To search for variants of PAX6 gene in patients with nonsyndromic supernumerary teeth in the maxillary incisor area (NSST) and compare genotypes and allele frequencies of the detected polymorphisms between the patients and controls.

Design.

Twenty children with NSST and 31 controls were included. Genomic DNA was extracted from buccal epithelial cells of each individual. Sequencing analysis of all exons and exon/intron boundaries of PAX6 gene were performed in patients. Genotypes and allele frequencies of the single nucleotide polymorphisms detected in patients were compared between the two groups using chi-square tests.

Results.

Of the 20 patients examined, six showed heterozygous for rs667773 and rs3026393 simultaneously. Among them, four possessed two supernumerary teeth and the other two possessed one. Another six patients showed heterozygous for rs3026393, five of which possessed only one supernumerary tooth and the other one possessed two. Of another six patients with homozygous rs3026393, three possessed one supernumerary tooth and the other three possessed two. The distributions of genotypes and alleles frequencies of single nucleotide polymorphisms rs667773 and rs3026393 showed no significant difference between the two groups.

Conclusions.

The present study did not find evidence of PAX6 polymorphisms being associated with supernumerary teeth in the population studied.

语种英语
所属项目编号20070001729
资助者Specialized Research Fund for the Doctoral Program of Higher Education of China ; Specialized Research Fund for the Doctoral Program of Higher Education of China
WOS记录号WOS:000291224000005
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56517
Collection北京大学口腔医学院_儿童口腔科
作者单位Peking Univ, Sch & Hosp Stomatol, Dept Pediat Dent, Beijing 100081, Peoples R China
Recommended Citation
GB/T 7714
Lei, Hai-Hua,Liu, He,Ge, Li-Hong. PAX6 polymorphisms in 20 Chinese children with supernumerary teeth in the maxillary incisor area[J]. INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY,2011,21(4):271-277.
APA Lei, Hai-Hua,Liu, He,&Ge, Li-Hong.(2011).PAX6 polymorphisms in 20 Chinese children with supernumerary teeth in the maxillary incisor area.INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY,21(4),271-277.
MLA Lei, Hai-Hua,et al."PAX6 polymorphisms in 20 Chinese children with supernumerary teeth in the maxillary incisor area".INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY 21.4(2011):271-277.
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