|PAX6 polymorphisms in 20 Chinese children with supernumerary teeth in the maxillary incisor area|
|Lei, Hai-Hua; Liu, He; Ge, Li-Hong|
|刊名||INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY|
|WOS标题词||Science & Technology|
|类目[WOS]||Dentistry, Oral Surgery & Medicine ; Pediatrics|
|研究领域[WOS]||Dentistry, Oral Surgery & Medicine ; Pediatrics|
|关键词[WOS]||CRANIOFACIAL ABNORMALITIES ; CLEIDOCRANIAL DYSPLASIA ; ANIRIDIA ; GENE ; MUTATIONS ; ASSOCIATION ; PATIENT ; MICE ; APC|
To search for variants of PAX6 gene in patients with nonsyndromic supernumerary teeth in the maxillary incisor area (NSST) and compare genotypes and allele frequencies of the detected polymorphisms between the patients and controls.
Twenty children with NSST and 31 controls were included. Genomic DNA was extracted from buccal epithelial cells of each individual. Sequencing analysis of all exons and exon/intron boundaries of PAX6 gene were performed in patients. Genotypes and allele frequencies of the single nucleotide polymorphisms detected in patients were compared between the two groups using chi-square tests.
Of the 20 patients examined, six showed heterozygous for rs667773 and rs3026393 simultaneously. Among them, four possessed two supernumerary teeth and the other two possessed one. Another six patients showed heterozygous for rs3026393, five of which possessed only one supernumerary tooth and the other one possessed two. Of another six patients with homozygous rs3026393, three possessed one supernumerary tooth and the other three possessed two. The distributions of genotypes and alleles frequencies of single nucleotide polymorphisms rs667773 and rs3026393 showed no significant difference between the two groups.
The present study did not find evidence of PAX6 polymorphisms being associated with supernumerary teeth in the population studied.
|资助机构||Specialized Research Fund for the Doctoral Program of Higher Education of China|
|作者单位||Peking Univ, Sch & Hosp Stomatol, Dept Pediat Dent, Beijing 100081, Peoples R China|
|Lei, Hai-Hua,Liu, He,Ge, Li-Hong. PAX6 polymorphisms in 20 Chinese children with supernumerary teeth in the maxillary incisor area[J]. INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY,2011,21(4):271-277.|
|APA||Lei, Hai-Hua,Liu, He,&Ge, Li-Hong.(2011).PAX6 polymorphisms in 20 Chinese children with supernumerary teeth in the maxillary incisor area.INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY,21(4),271-277.|
|MLA||Lei, Hai-Hua,et al."PAX6 polymorphisms in 20 Chinese children with supernumerary teeth in the maxillary incisor area".INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY 21.4(2011):271-277.|