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学科主题基础医学
CAFFEIC ACID PHENETHYL ESTER PREVENTS 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-INDUCED NEURODEGENERATION
Fontanilla, C. V.2; Ma, Z.2,3; Wei, X.2; Klotsche, J.4; Zhao, L.2; Wisniowski, P.5; Dodel, R. C.1; Farlow, M. R.2; Oertel, W. H.1; Du, Y.2
关键词Mptp Parkinson&Prime s Disease Mitochondria Cape
刊名NEUROSCIENCE
2011-08-11
DOI10.1016/j.neuroscience.2011.04.009
188页:135-141
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CEREBELLAR GRANULE NEURONS ; PARKINSONS-DISEASE ; 6-HYDROXYDOPAMINE-INDUCED NEUROTOXICITY ; DOPAMINERGIC NEURODEGENERATION ; MPTP MODEL ; MICE ; INTERLEUKIN-1-BETA ; MINOCYCLINE ; ACTIVATION ; APOPTOSIS
英文摘要

Parkinson′s disease is associated with the loss of dopaminergic neurons in the substantia nigra and decreased striatal dopamine levels. We now report that caffeic acid phenethyl ester (CAPE), an active component of propolis, attenuated dopaminergic neurodegeneration and dopamine loss in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson′s disease. The neuroprotective effect of CAPE was associated with marked reductions in inducible nitric oxide synthase (iNOS) and caspase 1 expression. Additionally, CAPE inhibited MPP(+)-induced neurotoxicity in vitro and directly inhibited MPP(+)-induced release of cytochrome c and apoptosis inducing factor (AIF) from mitochondria. Thus, CAPE may have beneficial effects in slowing or preventing the progression of Parkinson′s disease and other neurodegenerative disorders. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000292069400013
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56518
专题北京大学基础医学院
北京大学第一临床医学院_急诊科
北京大学第二临床医学院_检验科
作者单位1.Univ Marburg, Dept Neurol, Marburg, Germany
2.Peking Univ, Basic Med Sch, Beijing 100871, Peoples R China
3.Indiana Univ Sch Med, Dept Neurol, Indianapolis, IN 46202 USA
4.Tech Univ Dresden, Inst Clin Psychol & Psychotherapy, Dresden, Germany
5.Indiana Univ Sch Med, Dept Pediat, Indianapolis, IN 46202 USA
推荐引用方式
GB/T 7714
Fontanilla, C. V.,Ma, Z.,Wei, X.,et al. CAFFEIC ACID PHENETHYL ESTER PREVENTS 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-INDUCED NEURODEGENERATION[J]. NEUROSCIENCE,2011,188:135-141.
APA Fontanilla, C. V..,Ma, Z..,Wei, X..,Klotsche, J..,Zhao, L..,...&Du, Y..(2011).CAFFEIC ACID PHENETHYL ESTER PREVENTS 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-INDUCED NEURODEGENERATION.NEUROSCIENCE,188,135-141.
MLA Fontanilla, C. V.,et al."CAFFEIC ACID PHENETHYL ESTER PREVENTS 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-INDUCED NEURODEGENERATION".NEUROSCIENCE 188(2011):135-141.
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