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学科主题: 基础医学
题名:
CAFFEIC ACID PHENETHYL ESTER PREVENTS 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-INDUCED NEURODEGENERATION
作者: Fontanilla, C. V.2; Ma, Z.2,3; Wei, X.2; Klotsche, J.4; Zhao, L.2; Wisniowski, P.5; Dodel, R. C.1; Farlow, M. R.2; Oertel, W. H.1; Du, Y.2
关键词: MPTP ; Parkinson&prime ; s disease ; mitochondria ; CAPE
刊名: NEUROSCIENCE
发表日期: 2011-08-11
DOI: 10.1016/j.neuroscience.2011.04.009
卷: 188, 页:135-141
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CEREBELLAR GRANULE NEURONS ; PARKINSONS-DISEASE ; 6-HYDROXYDOPAMINE-INDUCED NEUROTOXICITY ; DOPAMINERGIC NEURODEGENERATION ; MPTP MODEL ; MICE ; INTERLEUKIN-1-BETA ; MINOCYCLINE ; ACTIVATION ; APOPTOSIS
英文摘要:

Parkinson′s disease is associated with the loss of dopaminergic neurons in the substantia nigra and decreased striatal dopamine levels. We now report that caffeic acid phenethyl ester (CAPE), an active component of propolis, attenuated dopaminergic neurodegeneration and dopamine loss in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson′s disease. The neuroprotective effect of CAPE was associated with marked reductions in inducible nitric oxide synthase (iNOS) and caspase 1 expression. Additionally, CAPE inhibited MPP(+)-induced neurotoxicity in vitro and directly inhibited MPP(+)-induced release of cytochrome c and apoptosis inducing factor (AIF) from mitochondria. Thus, CAPE may have beneficial effects in slowing or preventing the progression of Parkinson′s disease and other neurodegenerative disorders. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.

语种: 英语
项目资助者: Philipps University in Marburg, Germany
WOS记录号: WOS:000292069400013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56518
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Univ Marburg, Dept Neurol, Marburg, Germany
2.Peking Univ, Basic Med Sch, Beijing 100871, Peoples R China
3.Indiana Univ Sch Med, Dept Neurol, Indianapolis, IN 46202 USA
4.Tech Univ Dresden, Inst Clin Psychol & Psychotherapy, Dresden, Germany
5.Indiana Univ Sch Med, Dept Pediat, Indianapolis, IN 46202 USA

Recommended Citation:
Fontanilla, C. V.,Ma, Z.,Wei, X.,et al. CAFFEIC ACID PHENETHYL ESTER PREVENTS 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-INDUCED NEURODEGENERATION[J]. NEUROSCIENCE,2011,188:135-141.
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