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学科主题: 精神卫生
题名:
Comparative study of OROS-MPH and atomoxetine on executive function improvement in ADHD: a randomized controlled trial
作者: Yang, Li1; Cao, Qingjiu1; Shuai, Lan1; Li, Haimei1; Chan, Raymond C. K.2; Wang, Yufeng1
关键词: Attention deficit hyperactivity disorder ; atomoxetine ; executive function ; osmotic release oral system-methylphenidate (OROS-MPH)
刊名: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
发表日期: 2012-02-01
DOI: 10.1017/S1461145711001490
卷: 15, 期:1, 页:15-26
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: DEFICIT-HYPERACTIVITY DISORDER ; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; WORKING-MEMORY PERFORMANCE ; ONCE-DAILY ATOMOXETINE ; PREFRONTAL CORTEX ; STIMULANT MEDICATION ; RESPONSE-INHIBITION ; TASK-PERFORMANCE ; STROOP COLOR ; OPEN-LABEL
英文摘要:

This study aimed to compare the effects of osmotic release oral system-methylphenidate (OROS-MPH) and atomoxetine (ATX) on executive function in children and adolescents with attention deficit hyperactivity disorder (ADHD) by a randomized controlled trial. Subjects who met DSM-IV ADHD criteria were randomized to receive either OROS-MPH or ATX treatment. The doses were titrated to achieve optimal response and then maintained for 4-6 wk. A battery of executive function tests and the Behavior Rating Inventory of Executive Function (BRIEF) were administered to subjects who completed the dose titration (OROS-MPH, n = 85; ATX, n = 57) at the pre- and post-treatment periods. Forty-six children without ADHD were recruited as controls. Both OROS-MPH and ATX significantly improved scores in the Rey Complex Figure Test (RCFT), digit span, and Stroop color-word task. The scores in RCFT and the reverse digit span were not significantly different from the control group at post-treatment assessment (OROS-MPH = ATX = control, p > 0.05), whereas the word interference time of the Stroop test was still more than that of the control group (OROS-MPH = ATX > control, p > 0.05). OROS-MPH also significantly improved the total correct response in the verbal fluency test to normal level, and the shifting time in the trail-making test to subnormal level. The current findings suggest both OROS-MPH and ATX improved executive function generally in children and adolescents with ADHD, and could return working memory back to normative performance level.

语种: 英语
所属项目编号: 30800302 ; 200802073 ; 2007BAI17B03 ; CON-I-07-CN-029-B
项目资助者: National Natural Science Foundation of China ; Chinese Ministry of Health ; Ministry of Science and Technology ; Xian-Janssen Pharmaceutical Ltd ; Xian-Janssen ; Eli Lilly
WOS记录号: WOS:000299498600002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56521
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Beijing 100101, Peoples R China

Recommended Citation:
Yang, Li,Cao, Qingjiu,Shuai, Lan,et al. Comparative study of OROS-MPH and atomoxetine on executive function improvement in ADHD: a randomized controlled trial[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,2012,15(1):15-26.
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