北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 骨科  > 期刊论文
学科主题: 临床医学
题名:
Simvastatin induces estrogen receptor-alpha expression in bone, restores bone loss, and decreases ER alpha expression and uterine wet weight in ovariectomized rats
作者: Li, Xu; Song, Quan-Sheng; Wang, Jing-Ying; Leng, Hui-Jie; Chen, Zhong-Qiang; Liu, Zhong-Jun; Dang, Geng-Ting; Song, Chun-Li
关键词: Simvastatin ; Osteoporosis ; Estrogen receptor-alpha (ER alpha) ; Bone ; Uterus
刊名: JOURNAL OF BONE AND MINERAL METABOLISM
发表日期: 2011-07-01
DOI: 10.1007/s00774-010-0231-y
卷: 29, 期:4, 页:396-403
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Medicine, Research & Experimental
研究领域[WOS]: Endocrinology & Metabolism ; Research & Experimental Medicine
关键词[WOS]: HYPERCHOLESTEROLEMIC POSTMENOPAUSAL WOMEN ; HORMONE-REPLACEMENT THERAPY ; ENDOMETRIAL STROMAL CELLS ; NEGATIVE BREAST-CANCER ; MINERAL DENSITY ; IN-VITRO ; STATINS ; GROWTH ; INHIBITORS ; ESTRADIOL
英文摘要:

We previously reported that simvastatin induces estrogen receptor-alpha (ER alpha) in murine bone marrow stromal cells in vitro. In this study, we investigated the effect of simvastatin on ER alpha expression in bone and uterus in ovariectomized (OVX) rats and evaluated bone mass, bone strength, and uterine wet weight. Three-month-old Sprague-Dawley female rats received OVX or sham operation. Six weeks later, the rats were treated orally with simvastatin (5 or 10 mg/kg/day), or intraperitoneally with 17-beta-estradiol (E(2)) or a combination of simvastatin and E(2) for 6 weeks. Uterine wet weight, bone mineral density (BMD) of lumbar vertebrae, biomechanics of lumbar vertebrae, and induction of ER alpha expression in the bone and uterus were analyzed. The 6-week simvastatin treatment improved lumbar vertebral BMD and boosted biomechanical performance of the vertebral body compared to the OVX control, suggesting that simvastatin can treat osteoporosis caused by estrogen deficiency. More interestingly, simvastatin could increase ER alpha expression and synergy with estradiol in bone while antagonizing estradiol in the uterus, along with uterus atrophy and uterine wet weight decreases. In conclusion, these data suggest that simvastatin exert opposing modulatory effects on ER alpha expression on bone and uterus in ovariectomized rats, inducing ER alpha expression and synergy with estrogen to perform anabolic effects on the bones while decreasing E2 efficacy and uterine wet weight. This finding may be helpful to explain the mechanism of statin treatment in osteoporosis caused by estrogen deficiency.

语种: 英语
所属项目编号: 30300352 ; 30772200
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000292607100002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56529
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Hosp 3, Dept Orthoped, Beijing 100191, Peoples R China

Recommended Citation:
Li, Xu,Song, Quan-Sheng,Wang, Jing-Ying,et al. Simvastatin induces estrogen receptor-alpha expression in bone, restores bone loss, and decreases ER alpha expression and uterine wet weight in ovariectomized rats[J]. JOURNAL OF BONE AND MINERAL METABOLISM,2011,29(4):396-403.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Li, Xu]'s Articles
[Song, Quan-Sheng]'s Articles
[Wang, Jing-Ying]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Li, Xu]‘s Articles
[Song, Quan-Sheng]‘s Articles
[Wang, Jing-Ying]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace