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Phagocytosis of platelets enhances endothelial cell survival under serum deprivation
Jiang, Ping1,2; Ren, Ya-Li3; Lan, Yong4; Li, Jia-Liang5; Luo, Jun1,2; Li, Jian1,2; Cai, Jian-Ping1,2
关键词Phagocytosis Platelet Apoptosis
刊名EXPERIMENTAL BIOLOGY AND MEDICINE
2015-07-01
DOI10.1177/1535370214565076
240期:7页:876-883
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]RICH PLASMA ; IN-VITRO ; MICROPARTICLES ; ANGIOGENESIS ; RELEASE
英文摘要

Platelets are key players in fundamental processes of vascular biology, such as angiogenesis, tissue regeneration, and tumor metastasis. However, the underlying mechanisms remain unclear. In this study, some tumor vascular endothelial cells were positively stained by antiplatelet antibodies. Further investigation revealed that platelets were taken up by endothelial cells in vitro and in vivo. Human umbilical vascular endothelial cells were rendered apoptotic under conditions of serum deprivation. However, endothelial apoptosis was suppressed and cell viability was enhanced when platelets were added to the cultures. Endothelial survival was paralleled by an upregulation of phosphorylated Akt and p70 S6K. In conclusion, this study demonstrated that platelets can be phagocytosed by endothelial cells, and the phagocytosed platelets could suppress endothelial apoptosis and promote cell viability level. The mechanism underlying this process involves the activation of Akt signaling.

语种英语
WOS记录号WOS:000357740100005
项目编号31371160 ; 201104043 ; jws1433
资助机构National Natural Science Foundation of China ; China Postdoctoral Science Foundation special funded project ; Scientific Research Foundation of the Education Ministry for returned Chinese scholars
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56534
专题北京大学第一临床医学院
北京大学第一临床医学院_电镜室
作者单位1.Beijing Hosp, Key Lab Geriatr, Beijing 100730, Peoples R China
2.Beijing Inst Geriatr, Minist Hlth, Beijing 100730, Peoples R China
3.Peking Univ, Hosp 1, Lab Electron Microscopy, Beijing 100034, Peoples R China
4.Beijing Hosp, Minist Hlth, Dept Vasc Surg, Beijing 100730, Peoples R China
5.Guangzhou Fuda Canc Hosp, Clin Lab, Guangzhou 510665, Guangdong, Peoples R China
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GB/T 7714
Jiang, Ping,Ren, Ya-Li,Lan, Yong,et al. Phagocytosis of platelets enhances endothelial cell survival under serum deprivation[J]. EXPERIMENTAL BIOLOGY AND MEDICINE,2015,240(7):876-883.
APA Jiang, Ping.,Ren, Ya-Li.,Lan, Yong.,Li, Jia-Liang.,Luo, Jun.,...&Cai, Jian-Ping.(2015).Phagocytosis of platelets enhances endothelial cell survival under serum deprivation.EXPERIMENTAL BIOLOGY AND MEDICINE,240(7),876-883.
MLA Jiang, Ping,et al."Phagocytosis of platelets enhances endothelial cell survival under serum deprivation".EXPERIMENTAL BIOLOGY AND MEDICINE 240.7(2015):876-883.
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