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学科主题: 基础医学
题名:
Isolation of the differentially expressed genes in the BXSB mouse model of systemic lupus erythematosus by cDNA-RDA technique.
作者: Han, WL; Li, Y; Yang, GY; Song, QS; Zhang, YM; Di, CH; Ma, DL
关键词: systemic lupus erythematosus ; representational difference analysis ; BXSB mice
刊名: PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
发表日期: 2000-06-01
卷: 27, 期:3, 页:305-308
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: CHROMOSOME ; IMMUNITY ; STRAIN
英文摘要:

In order to isolate the related genes in the development of systemic lupus erythematosus (SLE) in BXSB mice, bone marrow cells were separated from the BXSB and C57-BL-6 mouse, poly (A) RNA was extracted, the cDNAs were synthesized by reverse transcription, and the differentially expressed genes were cloned by cDNA-representational difference analysis (RDA). Three novel genes were isolated, their accession numbers in GenBank are AF060113, AF060111, AF060110; at the same time, some genes that have been reported to be related to the development of SLE such as endogenous retrovirus and Line -1 reverse transcriptase were found. This can provide a novel method to do further research about autoimmune diseases.

语种: 中文
WOS记录号: WOS:000087859200021
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56536
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: Beijing Med Univ, Dept Immunol, Beijing 100083, Peoples R China

Recommended Citation:
Han, WL,Li, Y,Yang, GY,et al. Isolation of the differentially expressed genes in the BXSB mouse model of systemic lupus erythematosus by cDNA-RDA technique.[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2000,27(3):305-308.
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