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学科主题基础医学
Isolation of the differentially expressed genes in the BXSB mouse model of systemic lupus erythematosus by cDNA-RDA technique.
Han, WL; Li, Y; Yang, GY; Song, QS; Zhang, YM; Di, CH; Ma, DL
关键词systemic lupus erythematosus representational difference analysis BXSB mice
刊名PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
2000-06-01
27期:3页:305-308
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]CHROMOSOME ; IMMUNITY ; STRAIN
英文摘要

In order to isolate the related genes in the development of systemic lupus erythematosus (SLE) in BXSB mice, bone marrow cells were separated from the BXSB and C57-BL-6 mouse, poly (A) RNA was extracted, the cDNAs were synthesized by reverse transcription, and the differentially expressed genes were cloned by cDNA-representational difference analysis (RDA). Three novel genes were isolated, their accession numbers in GenBank are AF060113, AF060111, AF060110; at the same time, some genes that have been reported to be related to the development of SLE such as endogenous retrovirus and Line -1 reverse transcriptase were found. This can provide a novel method to do further research about autoimmune diseases.

语种中文
WOS记录号WOS:000087859200021
引用统计
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56536
专题北京大学基础医学院_免疫学系
作者单位Beijing Med Univ, Dept Immunol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Han, WL,Li, Y,Yang, GY,et al. Isolation of the differentially expressed genes in the BXSB mouse model of systemic lupus erythematosus by cDNA-RDA technique.[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2000,27(3):305-308.
APA Han, WL.,Li, Y.,Yang, GY.,Song, QS.,Zhang, YM.,...&Ma, DL.(2000).Isolation of the differentially expressed genes in the BXSB mouse model of systemic lupus erythematosus by cDNA-RDA technique..PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,27(3),305-308.
MLA Han, WL,et al."Isolation of the differentially expressed genes in the BXSB mouse model of systemic lupus erythematosus by cDNA-RDA technique.".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 27.3(2000):305-308.
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