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学科主题临床医学
Renal Function, Bisphenol A, and Alkylphenols: Results from the National Health and Nutrition Examination Survey (NHANES 2003-2006)
You, Li2,3; Zhu, Xiangzhu; Shrubsole, Martha J.; Fan, Hong2,3; Chen, Jing2,3; Dong, Jie4,5; Hao, Chuan-Ming2,3,6; Dai, Qi1
关键词Renal Function Urinary Excretion
刊名ENVIRONMENTAL HEALTH PERSPECTIVES
2011-04-01
DOI10.1289/ehp.1002572
119期:4页:527-533
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
研究领域[WOS]Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
关键词[WOS]CHRONIC KIDNEY-DISEASE ; GLOMERULAR-FILTRATION-RATE ; SERUM CREATININE ; US POPULATION ; UNITED-STATES ; URINARY CONCENTRATIONS ; MASS-SPECTROMETRY ; HUMAN EXPOSURE ; NORMAL WOMEN ; PHARMACOKINETICS
英文摘要

BACKGROUND: Urinary excretion of bisphenol A (BPA) and alkylphenols (APs) was used as a biomarker in most previous studies, but no study has investigated whether urinary excretion of these environmental phenols differed by renal function.

OBJECTIVE: We estimated the association between renal function and urinary excretion of BPA and APs.

METHODS: Analyses were conducted using data from the National Health and Nutrition Examination Survey (NHANES) 2003-2006. Renal function was measured as estimated glomerular filtration rate (eGFR) calculated by the Modification of Diet in Renal Disease (MDRD) Study equation and by the newly developed Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Regression models were used to calculate geometric means of urinary BPA and APs excretion by eGFR category (>= 90, 60-90, <60 mL/min/m(2)) after adjusting for potential confounding factors.

RESULTS: When we used the MDRD Study equation, participants without known renal disease (n = 2,573), 58.2% (n = 1,499) had mildly decreased renal function or undiagnosed chronic kidney disease. The adjusted geometric means for urinary BPA excretion decreased with decreasing levels of eGFR (p for trend = 0.04). The associations appeared primarily in females (p for trend = 0.03). Urinary triclosan excretion decreased with decreasing levels of eGFR (p for trend <0.01) for both males and females, and the association primarily appeared in participants <65 years of age. The association between BPA and eGFR was nonsignificant when we used the CKD-EPI equation.

CONCLUSIONS: Urinary excretion of triclosan, and possibly BPA, decreased with decreasing renal function. The associations might differ by age or sex. Further studies are necessary to replicate our results and understand the mechanism.

语种英语
WOS记录号WOS:000289065900035
项目编号DK071876 ; DK074116
资助机构International Society of Nephrology ; National Institute of Diabetes and Digestive and Kidney Diseases
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56539
专题北京大学第一临床医学院_肾脏内科
作者单位1.Vanderbilt Univ, Vanderbilt Epidemiol Ctr, Inst Med & Publ Hlth, Dept Med,Sch Med, Nashville, TN 37203 USA
2.Fudan Univ, Inst Nephrol, Shanghai 200433, Peoples R China
3.Huashan Hosp, Div Nephrol, Shanghai, Peoples R China
4.Peking Univ, Dept Med, Div Renal, Hosp 1, Beijing 100871, Peoples R China
5.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
6.Vanderbilt Univ, Dept Med, Div Nephrol, Nashville, TN USA
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You, Li,Zhu, Xiangzhu,Shrubsole, Martha J.,et al. Renal Function, Bisphenol A, and Alkylphenols: Results from the National Health and Nutrition Examination Survey (NHANES 2003-2006)[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2011,119(4):527-533.
APA You, Li.,Zhu, Xiangzhu.,Shrubsole, Martha J..,Fan, Hong.,Chen, Jing.,...&Dai, Qi.(2011).Renal Function, Bisphenol A, and Alkylphenols: Results from the National Health and Nutrition Examination Survey (NHANES 2003-2006).ENVIRONMENTAL HEALTH PERSPECTIVES,119(4),527-533.
MLA You, Li,et al."Renal Function, Bisphenol A, and Alkylphenols: Results from the National Health and Nutrition Examination Survey (NHANES 2003-2006)".ENVIRONMENTAL HEALTH PERSPECTIVES 119.4(2011):527-533.
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