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IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科  > 期刊论文
学科主题: 临床医学
题名:
Renal Function, Bisphenol A, and Alkylphenols: Results from the National Health and Nutrition Examination Survey (NHANES 2003-2006)
作者: You, Li2,3; Zhu, Xiangzhu; Shrubsole, Martha J.; Fan, Hong2,3; Chen, Jing2,3; Dong, Jie4,5; Hao, Chuan-Ming2,3,6; Dai, Qi1
关键词: renal function ; urinary excretion
刊名: ENVIRONMENTAL HEALTH PERSPECTIVES
发表日期: 2011-04-01
DOI: 10.1289/ehp.1002572
卷: 119, 期:4, 页:527-533
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
研究领域[WOS]: Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
关键词[WOS]: CHRONIC KIDNEY-DISEASE ; GLOMERULAR-FILTRATION-RATE ; SERUM CREATININE ; US POPULATION ; UNITED-STATES ; URINARY CONCENTRATIONS ; MASS-SPECTROMETRY ; HUMAN EXPOSURE ; NORMAL WOMEN ; PHARMACOKINETICS
英文摘要:

BACKGROUND: Urinary excretion of bisphenol A (BPA) and alkylphenols (APs) was used as a biomarker in most previous studies, but no study has investigated whether urinary excretion of these environmental phenols differed by renal function.

OBJECTIVE: We estimated the association between renal function and urinary excretion of BPA and APs.

METHODS: Analyses were conducted using data from the National Health and Nutrition Examination Survey (NHANES) 2003-2006. Renal function was measured as estimated glomerular filtration rate (eGFR) calculated by the Modification of Diet in Renal Disease (MDRD) Study equation and by the newly developed Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Regression models were used to calculate geometric means of urinary BPA and APs excretion by eGFR category (>= 90, 60-90, <60 mL/min/m(2)) after adjusting for potential confounding factors.

RESULTS: When we used the MDRD Study equation, participants without known renal disease (n = 2,573), 58.2% (n = 1,499) had mildly decreased renal function or undiagnosed chronic kidney disease. The adjusted geometric means for urinary BPA excretion decreased with decreasing levels of eGFR (p for trend = 0.04). The associations appeared primarily in females (p for trend = 0.03). Urinary triclosan excretion decreased with decreasing levels of eGFR (p for trend <0.01) for both males and females, and the association primarily appeared in participants <65 years of age. The association between BPA and eGFR was nonsignificant when we used the CKD-EPI equation.

CONCLUSIONS: Urinary excretion of triclosan, and possibly BPA, decreased with decreasing renal function. The associations might differ by age or sex. Further studies are necessary to replicate our results and understand the mechanism.

语种: 英语
所属项目编号: DK071876 ; DK074116
项目资助者: International Society of Nephrology ; National Institute of Diabetes and Digestive and Kidney Diseases
WOS记录号: WOS:000289065900035
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56539
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Vanderbilt Univ, Vanderbilt Epidemiol Ctr, Inst Med & Publ Hlth, Dept Med,Sch Med, Nashville, TN 37203 USA
2.Fudan Univ, Inst Nephrol, Shanghai 200433, Peoples R China
3.Huashan Hosp, Div Nephrol, Shanghai, Peoples R China
4.Peking Univ, Dept Med, Div Renal, Hosp 1, Beijing 100871, Peoples R China
5.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
6.Vanderbilt Univ, Dept Med, Div Nephrol, Nashville, TN USA

Recommended Citation:
You, Li,Zhu, Xiangzhu,Shrubsole, Martha J.,et al. Renal Function, Bisphenol A, and Alkylphenols: Results from the National Health and Nutrition Examination Survey (NHANES 2003-2006)[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2011,119(4):527-533.
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