IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Antioxidative and acute anti-inflammatory effects of Campsis grandiflora flower
Cui, XY; Kim, JH; Zhao, X; Chen, BQ; Lee, BC; Pyo, HB; Yun, YP; Zhang, YH
关键词Campsis Grandiflora Antioxidant Activity Human Dermal Fibroblast Anti-inflammatory Activity Mice Car Edema
刊名JOURNAL OF ETHNOPHARMACOLOGY
2006-01-16
DOI10.1016/j.jep.2005.08.007
103期:2页:223-228
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]RADICAL SCAVENGING ACTIVITY ; INDUCED EAR EDEMA ; ARACHIDONIC-ACID ; 5-LIPOXYGENASE ; INFLAMMATION ; ACTIVATION ; SKIN
英文摘要

The present study was undertaken to investigate the antioxidative and anti-inflammatory activities of the extract of the flower of Campsis grandiflora (Thunb.) K. Schum. Exposure of human dermal fibroblasts to 50% EtOH extract of Campsis grandiflora flower (ECG) at 10 and 100 mu g/ml showed significant protective effect against hydrogen peroxide (300 mu M). ECG not only protected cell survival from H2O2-induced toxicity, but also inhibited the H2O2-induced leakage of lactate dehydrogenase (LDH) enzyme release and DNA fragmentation significantly. It was also found that ECG showed scavenging activities of radicals and reactive oxygen species with IC50 values of 20 mu g/ml against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and 52 mu g/ml against superoxide radicals in the xanthine/xanthine oxidase system, respectively. Topically applied ECG dose-dependently inhibited arachidonic acid (AA)- and 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear edema in mice. Consistent with its antioxidative properties in vitro, the present results suggest the therapeutic potential of ECG for acute skin inflammation that may involve oxidative tissue damage. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000234840100012
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56549
专题北京大学基础医学院_药理学系
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
2.Hanbul Cosmet, R&D Ctr, Umsung Kun 369830, Chungbuk, South Korea
3.Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea
推荐引用方式
GB/T 7714
Cui, XY,Kim, JH,Zhao, X,et al. Antioxidative and acute anti-inflammatory effects of Campsis grandiflora flower[J]. JOURNAL OF ETHNOPHARMACOLOGY,2006,103(2):223-228.
APA Cui, XY.,Kim, JH.,Zhao, X.,Chen, BQ.,Lee, BC.,...&Zhang, YH.(2006).Antioxidative and acute anti-inflammatory effects of Campsis grandiflora flower.JOURNAL OF ETHNOPHARMACOLOGY,103(2),223-228.
MLA Cui, XY,et al."Antioxidative and acute anti-inflammatory effects of Campsis grandiflora flower".JOURNAL OF ETHNOPHARMACOLOGY 103.2(2006):223-228.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Antioxidative and ac(274KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Cui, XY]的文章
[Kim, JH]的文章
[Zhao, X]的文章
百度学术
百度学术中相似的文章
[Cui, XY]的文章
[Kim, JH]的文章
[Zhao, X]的文章
必应学术
必应学术中相似的文章
[Cui, XY]的文章
[Kim, JH]的文章
[Zhao, X]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Antioxidative and acute anti-inflammatory effects of Campsis grandiflora flower.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。