北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 药理学系  > 期刊论文
学科主题: 基础医学
题名:
Antioxidative and acute anti-inflammatory effects of Campsis grandiflora flower
作者: Cui, XY; Kim, JH; Zhao, X; Chen, BQ; Lee, BC; Pyo, HB; Yun, YP; Zhang, YH
关键词: Campsis grandiflora ; antioxidant activity ; human dermal fibroblast ; anti-inflammatory activity ; mice car edema
刊名: JOURNAL OF ETHNOPHARMACOLOGY
发表日期: 2006-01-16
DOI: 10.1016/j.jep.2005.08.007
卷: 103, 期:2, 页:223-228
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]: RADICAL SCAVENGING ACTIVITY ; INDUCED EAR EDEMA ; ARACHIDONIC-ACID ; 5-LIPOXYGENASE ; INFLAMMATION ; ACTIVATION ; SKIN
英文摘要:

The present study was undertaken to investigate the antioxidative and anti-inflammatory activities of the extract of the flower of Campsis grandiflora (Thunb.) K. Schum. Exposure of human dermal fibroblasts to 50% EtOH extract of Campsis grandiflora flower (ECG) at 10 and 100 mu g/ml showed significant protective effect against hydrogen peroxide (300 mu M). ECG not only protected cell survival from H2O2-induced toxicity, but also inhibited the H2O2-induced leakage of lactate dehydrogenase (LDH) enzyme release and DNA fragmentation significantly. It was also found that ECG showed scavenging activities of radicals and reactive oxygen species with IC50 values of 20 mu g/ml against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and 52 mu g/ml against superoxide radicals in the xanthine/xanthine oxidase system, respectively. Topically applied ECG dose-dependently inhibited arachidonic acid (AA)- and 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear edema in mice. Consistent with its antioxidative properties in vitro, the present results suggest the therapeutic potential of ECG for acute skin inflammation that may involve oxidative tissue damage. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000234840100012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56549
Appears in Collections:基础医学院_药理学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
2.Hanbul Cosmet, R&D Ctr, Umsung Kun 369830, Chungbuk, South Korea
3.Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea

Recommended Citation:
Cui, XY,Kim, JH,Zhao, X,et al. Antioxidative and acute anti-inflammatory effects of Campsis grandiflora flower[J]. JOURNAL OF ETHNOPHARMACOLOGY,2006,103(2):223-228.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Cui, XY]'s Articles
[Kim, JH]'s Articles
[Zhao, X]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Cui, XY]‘s Articles
[Kim, JH]‘s Articles
[Zhao, X]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace