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学科主题基础医学
Egr-1 target genes in human endothelial cells identified by microarray analysis
Fu, MG; Zhu, XJ; Zhang, JF; Liang, J; Lin, YM; Zhao, LN; Ehrengruber, MU; Chen, YQE
关键词Transcription Functional Genomics Gene Expression Vascular Injury
刊名GENE
2003-10-02
DOI10.1016/S0378-1119(03)00730-3
315页:33-41
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
研究领域[WOS]Genetics & Heredity
关键词[WOS]VASCULAR SMOOTH-MUSCLE ; RESPONSE FACTOR-I ; RECOMBINANT ADENOVIRUS ; KINASE PATHWAY ; EXPRESSION ; TRANSCRIPTION ; INJURY ; RAD ; ATHEROSCLEROSIS ; PROLIFERATION
英文摘要

Early growth response factor 1 (Egr-1) is a key transcriptional factor to mediate gene expression after vascular injury. To better understand the role of Egr-1 in vasculature, we globally profiled Egr-1 target genes in human endothelial cells using adenoviral gene transfer and Affymetrix oligonucleotide-based microarray technology. More than 300 genes regulated by greater than or equal to 3-fold with Egr-1 overexpression were identified and, partially, confirmed by Northern and Western blotting, including genes for transcriptional regulators, signaling proteins, cell cycle regulatory proteins, growth factors, and cytokines. Among them, thymus-expressed chemokine (TECK) and IP-30 were dramatically induced by Egr-1, but TNFalpha-related apoptosis inducing ligand (TRAIL) was significantly repressed by Egr-1, suggesting that Egr-1 is a key mediator of inflammation and apoptosis in vascular cells. These data provide novel Egr-1 target genes and contribute to the understanding of the role of Egr-1 in vasculature. (C) 2003 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000186225000004
Citation statistics
Cited Times:115[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56550
Collection北京大学基础医学院_心血管所
作者单位1.Morehouse Sch Med, Cardiovasc Res Inst, Dept Biochem, Atlanta, GA 30310 USA
2.Peking Univ, Hlth Sci Ctr, Cardiovasc Res Inst, Beijing 100083, Peoples R China
3.Univ Zurich, Brain Res Inst, CH-8057 Zurich, Switzerland
Recommended Citation
GB/T 7714
Fu, MG,Zhu, XJ,Zhang, JF,et al. Egr-1 target genes in human endothelial cells identified by microarray analysis[J]. GENE,2003,315:33-41.
APA Fu, MG.,Zhu, XJ.,Zhang, JF.,Liang, J.,Lin, YM.,...&Chen, YQE.(2003).Egr-1 target genes in human endothelial cells identified by microarray analysis.GENE,315,33-41.
MLA Fu, MG,et al."Egr-1 target genes in human endothelial cells identified by microarray analysis".GENE 315(2003):33-41.
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