IR@PKUHSC  > 基础医学院  > 心血管所
学科主题基础医学
Egr-1 target genes in human endothelial cells identified by microarray analysis
Fu, MG; Zhu, XJ; Zhang, JF; Liang, J; Lin, YM; Zhao, LN; Ehrengruber, MU; Chen, YQE
关键词Transcription Functional Genomics Gene Expression Vascular Injury
刊名GENE
2003-10-02
DOI10.1016/S0378-1119(03)00730-3
315页:33-41
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
研究领域[WOS]Genetics & Heredity
关键词[WOS]VASCULAR SMOOTH-MUSCLE ; RESPONSE FACTOR-I ; RECOMBINANT ADENOVIRUS ; KINASE PATHWAY ; EXPRESSION ; TRANSCRIPTION ; INJURY ; RAD ; ATHEROSCLEROSIS ; PROLIFERATION
英文摘要

Early growth response factor 1 (Egr-1) is a key transcriptional factor to mediate gene expression after vascular injury. To better understand the role of Egr-1 in vasculature, we globally profiled Egr-1 target genes in human endothelial cells using adenoviral gene transfer and Affymetrix oligonucleotide-based microarray technology. More than 300 genes regulated by greater than or equal to 3-fold with Egr-1 overexpression were identified and, partially, confirmed by Northern and Western blotting, including genes for transcriptional regulators, signaling proteins, cell cycle regulatory proteins, growth factors, and cytokines. Among them, thymus-expressed chemokine (TECK) and IP-30 were dramatically induced by Egr-1, but TNFalpha-related apoptosis inducing ligand (TRAIL) was significantly repressed by Egr-1, suggesting that Egr-1 is a key mediator of inflammation and apoptosis in vascular cells. These data provide novel Egr-1 target genes and contribute to the understanding of the role of Egr-1 in vasculature. (C) 2003 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000186225000004
引用统计
被引频次:115[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56550
专题基础医学院_心血管所
作者单位1.Morehouse Sch Med, Cardiovasc Res Inst, Dept Biochem, Atlanta, GA 30310 USA
2.Peking Univ, Hlth Sci Ctr, Cardiovasc Res Inst, Beijing 100083, Peoples R China
3.Univ Zurich, Brain Res Inst, CH-8057 Zurich, Switzerland
推荐引用方式
GB/T 7714
Fu, MG,Zhu, XJ,Zhang, JF,et al. Egr-1 target genes in human endothelial cells identified by microarray analysis[J]. GENE,2003,315:33-41.
APA Fu, MG.,Zhu, XJ.,Zhang, JF.,Liang, J.,Lin, YM.,...&Chen, YQE.(2003).Egr-1 target genes in human endothelial cells identified by microarray analysis.GENE,315,33-41.
MLA Fu, MG,et al."Egr-1 target genes in human endothelial cells identified by microarray analysis".GENE 315(2003):33-41.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
1-s2.0-S037811190300(577KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Fu, MG]的文章
[Zhu, XJ]的文章
[Zhang, JF]的文章
百度学术
百度学术中相似的文章
[Fu, MG]的文章
[Zhu, XJ]的文章
[Zhang, JF]的文章
必应学术
必应学术中相似的文章
[Fu, MG]的文章
[Zhu, XJ]的文章
[Zhang, JF]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 1-s2.0-S0378111903007303-main.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。