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Effect of renewed SS-cream on spinal somatosensory evoked potential in rabbits
Tian, L; Xin, ZC; Xin, H; Fu, J; Yuan, YM; Liu, WJ; Yang, C
关键词Renewed Ss-cream Premature Ejaculation Spinal Somatosensory Evoked Potential
刊名ASIAN JOURNAL OF ANDROLOGY
2004-03-01
6期:1页:15-18
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Andrology ; Urology & Nephrology
研究领域[WOS]Endocrinology & Metabolism ; Urology & Nephrology
关键词[WOS]PRIMARY PREMATURE EJACULATION ; PENILE SENSITIVITY ; DYSFUNCTION ; MEN
英文摘要

Aim: The effect of a renewed SS-cream (RSSC) on the treatment of premature ejaculation (PE) was evaluated and compared with the original SS-cream (OSSC). Methods: Sixty male white New Zealand rabbits, weighing 2.5kg-3.0 kg, were divided at random into 3 groups: the RSSC, OSSC and placebo groups. The spinal somatosensory evoked potential (SSEP) elicited by electric stimulation of the glans penis with disk electrode was investigated with an electrophysiograph (Poseidomn, Shanghai, China) before and 10, 30 and 60 min after drug or placebo application on the glans. The Onset and the N 1 latencies and the amplitude of SSEP were recorded and analyzed. Results: There was no significant difference (P>0.05) in the mean Onset and N1 latency of SSEP among the 3 groups before drug application. Compared with the pre-application value, the mean Onset and N1 latencies in the RSSC and OSSC groups were significantly prolonged at 10, 30 and 60 min after treatment (P<0.05), while they were not significantly changed (P>0.05) in the placebo group. The mean Onset latency of RSSC at 10 and 30 min and that of OSSC at 30 min were significantly delayed (P<0.05) compared with the placebo group. The mean NI latency of RSSC at 30 and 60 min and that of OSSC group at 30 min were also significantly delayed (P<0.05). Conclusion: RSSC delays the latencies of SSEP, suggesting a local desensitizing effect on the sensory receptor of the glans penis dorsal nerve, which provides the potential for PE treatment. The desensitizing effect of RSSC is higher than that of OSSC.

语种英语
WOS记录号WOS:000220310000002
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56554
专题北京大学第一临床医学院_泌尿外科
作者单位1.Peking Univ, Hosp 1, Dept Urol, Beijing 100034, Peoples R China
2.Wuhan Univ, Renmin Hosp, Dept Urol, Wuhan 430060, Peoples R China
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GB/T 7714
Tian, L,Xin, ZC,Xin, H,et al. Effect of renewed SS-cream on spinal somatosensory evoked potential in rabbits[J]. ASIAN JOURNAL OF ANDROLOGY,2004,6(1):15-18.
APA Tian, L.,Xin, ZC.,Xin, H.,Fu, J.,Yuan, YM.,...&Yang, C.(2004).Effect of renewed SS-cream on spinal somatosensory evoked potential in rabbits.ASIAN JOURNAL OF ANDROLOGY,6(1),15-18.
MLA Tian, L,et al."Effect of renewed SS-cream on spinal somatosensory evoked potential in rabbits".ASIAN JOURNAL OF ANDROLOGY 6.1(2004):15-18.
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