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学科主题: 临床医学
题名:
Effect of renewed SS-cream on spinal somatosensory evoked potential in rabbits
作者: Tian, L; Xin, ZC; Xin, H; Fu, J; Yuan, YM; Liu, WJ; Yang, C
关键词: renewed SS-cream ; premature ejaculation ; spinal somatosensory evoked potential
刊名: ASIAN JOURNAL OF ANDROLOGY
发表日期: 2004-03-01
卷: 6, 期:1, 页:15-18
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Andrology ; Urology & Nephrology
研究领域[WOS]: Endocrinology & Metabolism ; Urology & Nephrology
关键词[WOS]: PRIMARY PREMATURE EJACULATION ; PENILE SENSITIVITY ; DYSFUNCTION ; MEN
英文摘要:

Aim: The effect of a renewed SS-cream (RSSC) on the treatment of premature ejaculation (PE) was evaluated and compared with the original SS-cream (OSSC). Methods: Sixty male white New Zealand rabbits, weighing 2.5kg-3.0 kg, were divided at random into 3 groups: the RSSC, OSSC and placebo groups. The spinal somatosensory evoked potential (SSEP) elicited by electric stimulation of the glans penis with disk electrode was investigated with an electrophysiograph (Poseidomn, Shanghai, China) before and 10, 30 and 60 min after drug or placebo application on the glans. The Onset and the N 1 latencies and the amplitude of SSEP were recorded and analyzed. Results: There was no significant difference (P>0.05) in the mean Onset and N1 latency of SSEP among the 3 groups before drug application. Compared with the pre-application value, the mean Onset and N1 latencies in the RSSC and OSSC groups were significantly prolonged at 10, 30 and 60 min after treatment (P<0.05), while they were not significantly changed (P>0.05) in the placebo group. The mean Onset latency of RSSC at 10 and 30 min and that of OSSC at 30 min were significantly delayed (P<0.05) compared with the placebo group. The mean NI latency of RSSC at 30 and 60 min and that of OSSC group at 30 min were also significantly delayed (P<0.05). Conclusion: RSSC delays the latencies of SSEP, suggesting a local desensitizing effect on the sensory receptor of the glans penis dorsal nerve, which provides the potential for PE treatment. The desensitizing effect of RSSC is higher than that of OSSC.

语种: 英语
WOS记录号: WOS:000220310000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56554
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Urol, Beijing 100034, Peoples R China
2.Wuhan Univ, Renmin Hosp, Dept Urol, Wuhan 430060, Peoples R China

Recommended Citation:
Tian, L,Xin, ZC,Xin, H,et al. Effect of renewed SS-cream on spinal somatosensory evoked potential in rabbits[J]. ASIAN JOURNAL OF ANDROLOGY,2004,6(1):15-18.
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