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学科主题临床医学
Counting sperm does not add up any more: time for a new equation?
Lefievre, Linda; Bedu-Addo, Kweku; Conner, Sarah J.; Machado-Oliveira, Gisela S. M.; Chen, Yongjian; Kirkman-Brown, Jackson C.; Afnan, Masoud A.; Publicover, Stephen J.; Ford, W. Christopher L.; Barratt, Christopher L. R.
刊名REPRODUCTION
2007-04-01
DOI10.1530/REP-06-0332
133期:4页:675-684
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Developmental Biology ; Reproductive Biology
研究领域[WOS]Developmental Biology ; Reproductive Biology
关键词[WOS]PROTEIN-TYROSINE PHOSPHORYLATION ; CAUDA EPIDIDYMAL SPERM ; SEMEN ANALYSIS STILL ; SEX GLAND FLUID ; HUMAN SPERMATOZOA ; PROTEOMIC ANALYSIS ; KINASE-A ; INTRAUTERINE INSEMINATION ; ELECTROPHORETIC ANALYSIS ; SIGNALING PATHWAYS
英文摘要

Although sperm dysfunction is the single most common cause of infertility, we have poor methods of diagnosis and surprisingly no effective treatment (excluding assisted reproductive technology). In this review, we challenge the usefulness of a basic semen analysis and argue that a new paradigm is required immediately. We discuss the use of at-home screening to potentially improve the diagnosis of the male and to streamline the management of the sub-fertile couple. Additionally, we outline the recent progress in the field, for example, in proteomics, which will allow the development of new biomarkers of sperm function. This new knowledge will transform our understanding of the spermatozoon as a machine and is likely to lead to non-ART treatments for men with sperm dysfunction.

语种英语
WOS记录号WOS:000246963900001
引用统计
被引频次:56[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56557
专题北京大学第三临床医学院_生殖医学中心
作者单位1.Univ Birmingham, Sch Med, Div Reprod & Child Hlth, Reprod Biol & Genet Grp, Birmingham B15 2TT, W Midlands, England
2.Kwame Nkrumah Univ Sci & Technol, Sch Med Sci, Dept Physiol, Kumasi, Ghana
3.Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England
4.Peking Univ, Hosp 3, Ctr Reprod Med, Beijing 100083, Peoples R China
5.Birmingham Womens Hosp, Assisted Concept Unit, Birmingham B15 2TG, W Midlands, England
推荐引用方式
GB/T 7714
Lefievre, Linda,Bedu-Addo, Kweku,Conner, Sarah J.,et al. Counting sperm does not add up any more: time for a new equation?[J]. REPRODUCTION,2007,133(4):675-684.
APA Lefievre, Linda.,Bedu-Addo, Kweku.,Conner, Sarah J..,Machado-Oliveira, Gisela S. M..,Chen, Yongjian.,...&Barratt, Christopher L. R..(2007).Counting sperm does not add up any more: time for a new equation?.REPRODUCTION,133(4),675-684.
MLA Lefievre, Linda,et al."Counting sperm does not add up any more: time for a new equation?".REPRODUCTION 133.4(2007):675-684.
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