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Age-specific effects of early MK-801 treatment on working memory in female rats
Su, Yun-Ai1; Wang, Xiao-Dong2; Li, Ji-Tao1; Guo, Chun-Mei1; Feng, Yu1; Yang, Yang1; Huang, Run-Hu1; Si, Tian-Mei1
关键词Mk-801 N-methyl-d-aspartate Receptor Prepulse Inhibition Rat Working Memory
刊名NEUROREPORT
2011-06-11
DOI10.1097/WNR.0b013e328346e154
22期:8页:402-406
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]PREPULSE INHIBITION ; PERINATAL PHENCYCLIDINE ; SPATIAL MEMORY ; UP-REGULATION ; SCHIZOPHRENIA ; DEFICITS ; BRAIN ; DISRUPTION ; ADOLESCENT ; EXPOSURE
英文摘要

The N-methyl-D-aspartate receptor plays a crucial role in developmental plasticity. Evidence shows that neonatal exposure to N-methyl-D-aspartate receptor antagonists impairs cognition in adult rats. This study investigated whether neonatal MK-801 treatment would produce long-term and age-specific effects on working memory and sensorimotor gating in adolescent and adult female rats. After treatment with MK-801 at postnatal days (PND) 5-14, female rats exhibited slightly impaired working memory during adolescence (PND: 35-42). In contrast, working memory was remarkably disrupted in adult (PND: 63-70) female rats. However, prepulse inhibition and startle amplitudes were not significantly affected at both ages. These findings indicate that neonatal MK-801 elicits working memory deficits, especially in the postpuberty female rats. NeuroReport 22:402-406 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.

语种英语
WOS记录号WOS:000290036200008
项目编号30770775 ; 30800361 ; IMHYG2008-01
资助机构Natural Science Foundation of China ; Youth Foundation of Peking University Sixth Hospital
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56560
专题北京大学精神卫生研究所
作者单位1.Max Planck Inst Psychiat, D-80804 Munich, Germany
2.Peking Univ, Key Lab Mental Hlth Hlth, Natl Hlth Minist, Inst Mental Hlth, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Su, Yun-Ai,Wang, Xiao-Dong,Li, Ji-Tao,et al. Age-specific effects of early MK-801 treatment on working memory in female rats[J]. NEUROREPORT,2011,22(8):402-406.
APA Su, Yun-Ai.,Wang, Xiao-Dong.,Li, Ji-Tao.,Guo, Chun-Mei.,Feng, Yu.,...&Si, Tian-Mei.(2011).Age-specific effects of early MK-801 treatment on working memory in female rats.NEUROREPORT,22(8),402-406.
MLA Su, Yun-Ai,et al."Age-specific effects of early MK-801 treatment on working memory in female rats".NEUROREPORT 22.8(2011):402-406.
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