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学科主题: 精神卫生
题名:
Age-specific effects of early MK-801 treatment on working memory in female rats
作者: Su, Yun-Ai1; Wang, Xiao-Dong2; Li, Ji-Tao1; Guo, Chun-Mei1; Feng, Yu1; Yang, Yang1; Huang, Run-Hu1; Si, Tian-Mei1
关键词: MK-801 ; N-methyl-D-aspartate receptor ; prepulse inhibition ; rat ; working memory
刊名: NEUROREPORT
发表日期: 2011-06-11
DOI: 10.1097/WNR.0b013e328346e154
卷: 22, 期:8, 页:402-406
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: PREPULSE INHIBITION ; PERINATAL PHENCYCLIDINE ; SPATIAL MEMORY ; UP-REGULATION ; SCHIZOPHRENIA ; DEFICITS ; BRAIN ; DISRUPTION ; ADOLESCENT ; EXPOSURE
英文摘要:

The N-methyl-D-aspartate receptor plays a crucial role in developmental plasticity. Evidence shows that neonatal exposure to N-methyl-D-aspartate receptor antagonists impairs cognition in adult rats. This study investigated whether neonatal MK-801 treatment would produce long-term and age-specific effects on working memory and sensorimotor gating in adolescent and adult female rats. After treatment with MK-801 at postnatal days (PND) 5-14, female rats exhibited slightly impaired working memory during adolescence (PND: 35-42). In contrast, working memory was remarkably disrupted in adult (PND: 63-70) female rats. However, prepulse inhibition and startle amplitudes were not significantly affected at both ages. These findings indicate that neonatal MK-801 elicits working memory deficits, especially in the postpuberty female rats. NeuroReport 22:402-406 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.

语种: 英语
所属项目编号: 30770775 ; 30800361 ; IMHYG2008-01
项目资助者: Natural Science Foundation of China ; Youth Foundation of Peking University Sixth Hospital
WOS记录号: WOS:000290036200008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56560
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Max Planck Inst Psychiat, D-80804 Munich, Germany
2.Peking Univ, Key Lab Mental Hlth Hlth, Natl Hlth Minist, Inst Mental Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Su, Yun-Ai,Wang, Xiao-Dong,Li, Ji-Tao,et al. Age-specific effects of early MK-801 treatment on working memory in female rats[J]. NEUROREPORT,2011,22(8):402-406.
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