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学科主题: 临床医学
题名:
Metabolic Syndrome without Diabetes or Hypertension Still Necessitates Early Screening for Chronic Kidney Disease: Information from a Chinese National Cross-Sectional Study
作者: Hong, Daqing1,2; Zhang, Yuan1,2; Gao, Bixia3; Wang, Jinwei3; Li, Guisen1,2; Wang, Li1,2; Zhang, Luxia3; China Natl Survey CKD Working Grp
刊名: PLOS ONE
发表日期: 2015-07-10
DOI: 10.1371/journal.pone.0132220
卷: 10, 期:7
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: BODY-MASS INDEX ; RISK ; ASSOCIATION ; POPULATION ; PREVALENCE ; ADULTS ; COHORT ; CKD
英文摘要:

Metabolic syndrome (MS) is prevalent, with an increasing contribution to the incidence of chronic kidney disease (CKD). The study of the relationship between them is important. The CKD survey, a national cross-sectional study, provided a large database to accomplish this study. The study population were 41 131 adults from this survey between 2008 and 2009. CKD was defined as estimate glomerular filtration rate (eGFR) less than 60 mL/min per 1.73 m(2) or the presence of albuminuria. MS was diagnosed by National Cholesterol Education Program-Adult Treatment Panel III (ATPIII), ATPIII-modified or International Diabetes Federation (IDF) criteria. Logistic regression model was applied to study the impact of MS or its components on CKD or its components. The age and sex standardized prevalence of MS by ATPIII, ATPIII-modified and IDF criteria was 11.77% (11.13%-12.40%), 21.51% (20.69%-22.34%) and 16.67% (15.92-17.42)% respectively. Multivariate logistic regression models showed that MS and its components were associated with higher CKD prevalence. The risk for CKD and its components increased with the number of MS components. After adjusting for hypertension and diabetes, the odds ratios of MS for CKD decreased, but remained significantly more than 1 between 1.16(95% CI 1.07-1.26) and 1.37 (95% CI 1.25-1.50) across the different models. Similar results were found with albuminuria, while for decreased eGFR, after adjusting for hypertension and diabetes, the odds ratios of MS and MS components (except elevated TG) became insignificant. In conclusion, MS is prevalent and associated with a higher prevalence of CKD. Different MS components are associated with different risks for CKD, even after adjusting for hypertension and diabetes, which may mainly be contributed more by the increased risk for albuminuria than that for decreased eGFR. More attention must be paid to the population with MS, including those with elevated blood pressure and serum glucose.

语种: 英语
所属项目编号: 2007BAI04B10 ; 08dz1900502 ; 07JC14037 ; NZ08102 ; 30660069 ; H200936 ; 05SG1635 ; BMU2009131
项目资助者: National Key Technology R&amp ; D Program from the Ministry of Science and Technology (China) ; Science and Technology Commission of Shanghai ; Natural Science Funds of Ning Xia ; Science and Technology Department ; National Natural Science Funds ; National Natural Science Foundation of China ; Department of Health, Jiangsu Province ; Key Scientific and Technology Project from the Sichuan Science and Technology Department ; Program for New Century Excellent Talents in University from the Ministry of Education (China) ; International Society of Nephrology Research Committee ; China Health and Medical Development Foundation
WOS记录号: WOS:000358162300104
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56571
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Sichuan Acad Med Sci, Div Nephrol, Chengdu, Peoples R China
2.Sichuan Prov Peoples Hosp, Chengdu, Peoples R China
3.Peking Univ, Hosp 1, Inst Nephrol, Div Nephrol, Beijing 100871, Peoples R China

Recommended Citation:
Hong, Daqing,Zhang, Yuan,Gao, Bixia,et al. Metabolic Syndrome without Diabetes or Hypertension Still Necessitates Early Screening for Chronic Kidney Disease: Information from a Chinese National Cross-Sectional Study[J]. PLOS ONE,2015,10(7).
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