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学科主题临床医学
Metabolic Syndrome without Diabetes or Hypertension Still Necessitates Early Screening for Chronic Kidney Disease: Information from a Chinese National Cross-Sectional Study
Hong, Daqing1,2; Zhang, Yuan1,2; Gao, Bixia3; Wang, Jinwei3; Li, Guisen1,2; Wang, Li1,2; Zhang, Luxia3; China Natl Survey CKD Working Grp
刊名PLOS ONE
2015-07-10
DOI10.1371/journal.pone.0132220
10期:7
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]BODY-MASS INDEX ; RISK ; ASSOCIATION ; POPULATION ; PREVALENCE ; ADULTS ; COHORT ; CKD
英文摘要

Metabolic syndrome (MS) is prevalent, with an increasing contribution to the incidence of chronic kidney disease (CKD). The study of the relationship between them is important. The CKD survey, a national cross-sectional study, provided a large database to accomplish this study. The study population were 41 131 adults from this survey between 2008 and 2009. CKD was defined as estimate glomerular filtration rate (eGFR) less than 60 mL/min per 1.73 m(2) or the presence of albuminuria. MS was diagnosed by National Cholesterol Education Program-Adult Treatment Panel III (ATPIII), ATPIII-modified or International Diabetes Federation (IDF) criteria. Logistic regression model was applied to study the impact of MS or its components on CKD or its components. The age and sex standardized prevalence of MS by ATPIII, ATPIII-modified and IDF criteria was 11.77% (11.13%-12.40%), 21.51% (20.69%-22.34%) and 16.67% (15.92-17.42)% respectively. Multivariate logistic regression models showed that MS and its components were associated with higher CKD prevalence. The risk for CKD and its components increased with the number of MS components. After adjusting for hypertension and diabetes, the odds ratios of MS for CKD decreased, but remained significantly more than 1 between 1.16(95% CI 1.07-1.26) and 1.37 (95% CI 1.25-1.50) across the different models. Similar results were found with albuminuria, while for decreased eGFR, after adjusting for hypertension and diabetes, the odds ratios of MS and MS components (except elevated TG) became insignificant. In conclusion, MS is prevalent and associated with a higher prevalence of CKD. Different MS components are associated with different risks for CKD, even after adjusting for hypertension and diabetes, which may mainly be contributed more by the increased risk for albuminuria than that for decreased eGFR. More attention must be paid to the population with MS, including those with elevated blood pressure and serum glucose.

语种英语
WOS记录号WOS:000358162300104
项目编号2007BAI04B10 ; 08dz1900502 ; 07JC14037 ; NZ08102 ; 30660069 ; H200936 ; 05SG1635 ; BMU2009131
资助机构National Key Technology R&amp ; D Program from the Ministry of Science and Technology (China) ; Science and Technology Commission of Shanghai ; Natural Science Funds of Ning Xia ; Science and Technology Department ; National Natural Science Funds ; National Natural Science Foundation of China ; Department of Health, Jiangsu Province ; Key Scientific and Technology Project from the Sichuan Science and Technology Department ; Program for New Century Excellent Talents in University from the Ministry of Education (China) ; International Society of Nephrology Research Committee ; China Health and Medical Development Foundation
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56571
专题北京大学第一临床医学院_肾脏内科
作者单位1.Sichuan Acad Med Sci, Div Nephrol, Chengdu, Peoples R China
2.Sichuan Prov Peoples Hosp, Chengdu, Peoples R China
3.Peking Univ, Hosp 1, Inst Nephrol, Div Nephrol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Hong, Daqing,Zhang, Yuan,Gao, Bixia,et al. Metabolic Syndrome without Diabetes or Hypertension Still Necessitates Early Screening for Chronic Kidney Disease: Information from a Chinese National Cross-Sectional Study[J]. PLOS ONE,2015,10(7).
APA Hong, Daqing.,Zhang, Yuan.,Gao, Bixia.,Wang, Jinwei.,Li, Guisen.,...&China Natl Survey CKD Working Grp.(2015).Metabolic Syndrome without Diabetes or Hypertension Still Necessitates Early Screening for Chronic Kidney Disease: Information from a Chinese National Cross-Sectional Study.PLOS ONE,10(7).
MLA Hong, Daqing,et al."Metabolic Syndrome without Diabetes or Hypertension Still Necessitates Early Screening for Chronic Kidney Disease: Information from a Chinese National Cross-Sectional Study".PLOS ONE 10.7(2015).
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