|PRESENCE OF PERIPHERAL ARTERIAL DISEASE PREDICTS LOSS OF RESIDUAL RENAL FUNCTION IN INCIDENT CAPD PATIENTS|
|Tian, Shun-li2; Tian, Xin-kui1; Han, Qing-feng1; Axelsson, Jonas3; Wang, Tao1|
|关键词||Ankle Brachial Index End-stage Renal Disease Cardiovascular Disease Inflammation Nutrition Atherosclerosis|
|刊名||PERITONEAL DIALYSIS INTERNATIONAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Urology & Nephrology|
|研究领域[WOS]||Urology & Nephrology|
|关键词[WOS]||PERITONEAL-DIALYSIS PATIENTS ; RISK-FACTORS ; VASCULAR-DISEASE ; 1ST YEAR ; DECLINE ; MORTALITY ; HEMODIALYSIS ; INFLAMMATION ; ASSOCIATION ; PHOSPHORUS|
Background: Accelerated cardiovascular disease (CVD), including peripheral arterial disease (PAD), is very common in patients with end-stage renal disease. Residual renal function (RRF) is a strong predictor of patient survival that is suggested to be linked to the degree of CVD. However, the relationship between PAD and decline in RRF has not previously been measured.
Methods: We studied incident continuous ambulatory peritoneal dialysis patients from Peking University Third Hospital. An ankle brachial index of less than 0.9 was used to diagnose PAD. Residual renal function (RRF) was determined as the mean of 24-hour urea and creatinine clearances (glomerular filtration rate). The Cox proportional hazards model was used to identify factors predicting loss of RRF.
Results: The study included 86 patients (age: 61 +/- 14 years; men: 51%), 23 of whom had PAD at baseline. Mean follow-up was 19 months (median: 18 months; range: 6 - 30 months). In univariate analysis, baseline PAD, peritonitis during follow-up, inflammation (C-reactive protein), serum uric acid, CaxP, and serum phosphate were all significantly associated with a greater-than-50% decrease in RRF during follow-up. In multivariate analysis, only baseline PAD, CaxP, and peritonitis were independently associated with a decline in RRF.
Conclusions: Our study suggests that PAD may be a clinically important marker of CVD predicting the loss of RRF. It remains to be determined whether interventions aimed at decreasing PAD may also improve renal vascular status and thus slow the rate of RRF decline.
|作者单位||1.Peking Univ, Hosp 3, Div Nephrol, Beijing 100083, Peoples R China|
2.Tianjin Med Univ, Gen Hosp, Dept Geratol, Tianjin Geriatr Inst, Tianjin, Peoples R China
3.Karolinska Inst, Dept Clin Sci, Stockholm, Sweden
|Tian, Shun-li,Tian, Xin-kui,Han, Qing-feng,et al. PRESENCE OF PERIPHERAL ARTERIAL DISEASE PREDICTS LOSS OF RESIDUAL RENAL FUNCTION IN INCIDENT CAPD PATIENTS[J]. PERITONEAL DIALYSIS INTERNATIONAL,2012,32(1):67-72.|
|APA||Tian, Shun-li,Tian, Xin-kui,Han, Qing-feng,Axelsson, Jonas,&Wang, Tao.(2012).PRESENCE OF PERIPHERAL ARTERIAL DISEASE PREDICTS LOSS OF RESIDUAL RENAL FUNCTION IN INCIDENT CAPD PATIENTS.PERITONEAL DIALYSIS INTERNATIONAL,32(1),67-72.|
|MLA||Tian, Shun-li,et al."PRESENCE OF PERIPHERAL ARTERIAL DISEASE PREDICTS LOSS OF RESIDUAL RENAL FUNCTION IN INCIDENT CAPD PATIENTS".PERITONEAL DIALYSIS INTERNATIONAL 32.1(2012):67-72.|