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学科主题: 临床医学
题名:
PRESENCE OF PERIPHERAL ARTERIAL DISEASE PREDICTS LOSS OF RESIDUAL RENAL FUNCTION IN INCIDENT CAPD PATIENTS
作者: Tian, Shun-li2; Tian, Xin-kui1; Han, Qing-feng1; Axelsson, Jonas3; Wang, Tao1
关键词: Ankle brachial index ; end-stage renal disease ; cardiovascular disease ; inflammation ; nutrition ; atherosclerosis
刊名: PERITONEAL DIALYSIS INTERNATIONAL
发表日期: 2012
DOI: 10.3747/pdi.2010.00109
卷: 32, 期:1, 页:67-72
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: PERITONEAL-DIALYSIS PATIENTS ; RISK-FACTORS ; VASCULAR-DISEASE ; 1ST YEAR ; DECLINE ; MORTALITY ; HEMODIALYSIS ; INFLAMMATION ; ASSOCIATION ; PHOSPHORUS
英文摘要:

Background: Accelerated cardiovascular disease (CVD), including peripheral arterial disease (PAD), is very common in patients with end-stage renal disease. Residual renal function (RRF) is a strong predictor of patient survival that is suggested to be linked to the degree of CVD. However, the relationship between PAD and decline in RRF has not previously been measured.

Methods: We studied incident continuous ambulatory peritoneal dialysis patients from Peking University Third Hospital. An ankle brachial index of less than 0.9 was used to diagnose PAD. Residual renal function (RRF) was determined as the mean of 24-hour urea and creatinine clearances (glomerular filtration rate). The Cox proportional hazards model was used to identify factors predicting loss of RRF.

Results: The study included 86 patients (age: 61 +/- 14 years; men: 51%), 23 of whom had PAD at baseline. Mean follow-up was 19 months (median: 18 months; range: 6 - 30 months). In univariate analysis, baseline PAD, peritonitis during follow-up, inflammation (C-reactive protein), serum uric acid, CaxP, and serum phosphate were all significantly associated with a greater-than-50% decrease in RRF during follow-up. In multivariate analysis, only baseline PAD, CaxP, and peritonitis were independently associated with a decline in RRF.

Conclusions: Our study suggests that PAD may be a clinically important marker of CVD predicting the loss of RRF. It remains to be determined whether interventions aimed at decreasing PAD may also improve renal vascular status and thus slow the rate of RRF decline.

语种: 英语
WOS记录号: WOS:000299996200011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56572
Appears in Collections:北京大学第三临床医学院_肾内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Div Nephrol, Beijing 100083, Peoples R China
2.Tianjin Med Univ, Gen Hosp, Dept Geratol, Tianjin Geriatr Inst, Tianjin, Peoples R China
3.Karolinska Inst, Dept Clin Sci, Stockholm, Sweden

Recommended Citation:
Tian, Shun-li,Tian, Xin-kui,Han, Qing-feng,et al. PRESENCE OF PERIPHERAL ARTERIAL DISEASE PREDICTS LOSS OF RESIDUAL RENAL FUNCTION IN INCIDENT CAPD PATIENTS[J]. PERITONEAL DIALYSIS INTERNATIONAL,2012,32(1):67-72.
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