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Molecular chaperone heat shock protein 70 participates in the labile phase of the development of behavioural sensitization induced by a single morphine exposure in mice
Qin, Wang-Jun1; Wang, Yan-Ting1; Zhang, Min1; Wen, Rui-Ting1; Liu, Qing1; Li, Yu-Ling1; Chen, Feng2,3; Lawrence, Andrew J.2,3; Liang, Jian-Hui1
关键词Behavioural Sensitization Heat Shock Protein 70 Labile Phase Morphine
刊名INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
2013-04-01
DOI10.1017/S1461145712000557
16期:3页:647-659
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]NOVO PROTEIN-SYNTHESIS ; HEAT-SHOCK ; SYNAPTIC PLASTICITY ; NEURAL BASIS ; EXPRESSION ; ADDICTION ; HSP70 ; RAT ; BRAIN ; AMPHETAMINE
英文摘要

De-novo protein synthesis is required in the development of behavioural sensitization. A prior screening test from our laboratory has implicated heat shock protein 70 (Hsp70) as one of the proteins required in this behavioural plasticity. Thus, this study was designed to extend our understanding of the role of Hsp70 in the development of behavioural sensitization induced by a single morphine exposure in mice. First, by employing transcription inhibitor actinomycin D (AD) and protein synthesis inhibitor cycloheximide (CHX), we identified a protein synthesis-dependent labile phase (within 4 h after the first morphine injection) in the development of behavioural sensitization to a single morphine exposure. Second, Hsp70 protein expression in the nucleus accumbens correlated positively with locomotor responses of sensitized mice and, more importantly, the expression of Hsp70 increased within 1 h after the first morphine injection. Third, AD and CHX both prevented expression of Hsp70 and disrupted the development of the single morphine induced behavioural sensitization, which further implied Hsp70 was highly associated with behavioural sensitization. Finally, the selective Hsp70 inhibitor pifithrin-m (PES) i.c.v. injected in mice prevented the development of behavioural sensitization and, critically, this inhibitory effect occurred only when PES was given within 1 h after the first morphine injection, which was within the labile phase of the development period. Taken together, we draw the conclusion that Hsp70 is crucially involved in the labile phase of the development of behavioural sensitization induced by a single morphine exposure, probably functioning as a molecular chaperone.

语种英语
WOS记录号WOS:000315527600014
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56579
专题中国药物依赖性研究所
作者单位1.Univ Melbourne, Ctr Neurosci, Parkville, Vic 3052, Australia
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
3.Univ Melbourne, Florey Neurosci Inst, Parkville, Vic 3052, Australia
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Qin, Wang-Jun,Wang, Yan-Ting,Zhang, Min,et al. Molecular chaperone heat shock protein 70 participates in the labile phase of the development of behavioural sensitization induced by a single morphine exposure in mice[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,2013,16(3):647-659.
APA Qin, Wang-Jun.,Wang, Yan-Ting.,Zhang, Min.,Wen, Rui-Ting.,Liu, Qing.,...&Liang, Jian-Hui.(2013).Molecular chaperone heat shock protein 70 participates in the labile phase of the development of behavioural sensitization induced by a single morphine exposure in mice.INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,16(3),647-659.
MLA Qin, Wang-Jun,et al."Molecular chaperone heat shock protein 70 participates in the labile phase of the development of behavioural sensitization induced by a single morphine exposure in mice".INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 16.3(2013):647-659.
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