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学科主题: 基础医学
题名:
Functional evaluation of iodoacetic acid induced photoreceptor degeneration in the cat
作者: Nan Yan1; Zhang Qin2; Ren ChaoRan1; Huang Xin1; Gao Jie1; Li XiaoXin2; Pu MingLiang1
关键词: iodoacetic acid (IAA) ; photoreceptor ; retinal degeneration ; cat
刊名: SCIENCE CHINA-LIFE SCIENCES
发表日期: 2013-06-01
DOI: 10.1007/s11427-013-4483-3
卷: 56, 期:6, 页:524-530
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biology
研究领域[WOS]: Life Sciences & Biomedicine - Other Topics
关键词[WOS]: PROGRESSIVE RETINAL ATROPHY ; ABYSSINIAN CAT ; GANGLION-CELLS ; RABBIT RETINA ; EARLY-ONSET ; MODEL ; IODATE
英文摘要:

Iodoacetic acid (IAA) has been applied to different species to acutely induce photoreceptor degeneration. The purpose of the present study was to use this toxin to thoroughly eliminate photoreceptors and induce complete blindness in the cat. IAA was delivered by single ear vein injection (20 mg kg(-1)). Six months after the IAA treatment, functional evaluations including pupillary light reflex (PLR), electroretinogram (ERG), visual behavior tests were performed. Morphological examinations were carried out after the functional evaluation. The present result shows that, six months after the IAA application, animals lost visual functions and became completely blind. High dose IAA application via ear vein delivery created an acute and reliable complete photoreceptor degeneration model in the cat. This model can be applied to genetic and cellular therapies for visual function restoration.

语种: 英语
所属项目编号: 2009CB320900 ; 2011CB510206 ; 2011CB510200 ; 30831160516
项目资助者: National Basic Research Program of China ; National Natural Science Foundation of China
WOS记录号: WOS:000320035300006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56581
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Dept Anat Embryol, Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Peking Univ, Dept Ophthalmol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Nan Yan,Zhang Qin,Ren ChaoRan,et al. Functional evaluation of iodoacetic acid induced photoreceptor degeneration in the cat[J]. SCIENCE CHINA-LIFE SCIENCES,2013,56(6):524-530.
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