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学科主题基础医学
Functional evaluation of iodoacetic acid induced photoreceptor degeneration in the cat
Nan Yan1; Zhang Qin2; Ren ChaoRan1; Huang Xin1; Gao Jie1; Li XiaoXin2; Pu MingLiang1
关键词Iodoacetic Acid (Iaa) Photoreceptor Retinal Degeneration Cat
刊名SCIENCE CHINA-LIFE SCIENCES
2013-06-01
DOI10.1007/s11427-013-4483-3
56期:6页:524-530
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biology
研究领域[WOS]Life Sciences & Biomedicine - Other Topics
关键词[WOS]PROGRESSIVE RETINAL ATROPHY ; ABYSSINIAN CAT ; GANGLION-CELLS ; RABBIT RETINA ; EARLY-ONSET ; MODEL ; IODATE
英文摘要

Iodoacetic acid (IAA) has been applied to different species to acutely induce photoreceptor degeneration. The purpose of the present study was to use this toxin to thoroughly eliminate photoreceptors and induce complete blindness in the cat. IAA was delivered by single ear vein injection (20 mg kg(-1)). Six months after the IAA treatment, functional evaluations including pupillary light reflex (PLR), electroretinogram (ERG), visual behavior tests were performed. Morphological examinations were carried out after the functional evaluation. The present result shows that, six months after the IAA application, animals lost visual functions and became completely blind. High dose IAA application via ear vein delivery created an acute and reliable complete photoreceptor degeneration model in the cat. This model can be applied to genetic and cellular therapies for visual function restoration.

语种英语
WOS记录号WOS:000320035300006
项目编号2009CB320900 ; 2011CB510206 ; 2011CB510200 ; 30831160516
资助机构National Basic Research Program of China ; National Natural Science Foundation of China
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56581
专题北京大学基础医学院
作者单位1.Peking Univ, Dept Anat Embryol, Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Peking Univ, Dept Ophthalmol, Peoples Hosp, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Nan Yan,Zhang Qin,Ren ChaoRan,et al. Functional evaluation of iodoacetic acid induced photoreceptor degeneration in the cat[J]. SCIENCE CHINA-LIFE SCIENCES,2013,56(6):524-530.
APA Nan Yan.,Zhang Qin.,Ren ChaoRan.,Huang Xin.,Gao Jie.,...&Pu MingLiang.(2013).Functional evaluation of iodoacetic acid induced photoreceptor degeneration in the cat.SCIENCE CHINA-LIFE SCIENCES,56(6),524-530.
MLA Nan Yan,et al."Functional evaluation of iodoacetic acid induced photoreceptor degeneration in the cat".SCIENCE CHINA-LIFE SCIENCES 56.6(2013):524-530.
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