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学科主题: 临床医学
题名:
Expression of three essential antioxidants of Helicobacter pylori in clinical isolates
作者: Shi, Yan-yan; Chen, Mo; Zhang, Yue-xia; Zhang, Jing; Ding, Shi-gang
关键词: Antioxidant ; Gastric cancer ; Helicobacter pylori ; Oxidative stress
刊名: JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
发表日期: 2014-05-01
DOI: 10.1631/jzus.B1300171
卷: 15, 期:5, 页:500-506
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: GASTRIC-CANCER ; THIOREDOXIN SYSTEM ; REDUCTASE ; ARGINASE ; STRESS ; CELLS ; IDENTIFICATION ; RESISTANCE ; BACTERIAL ; PROTEINS
英文摘要:

Helicobacter pylori maintains long-term persistence in the host and combats oxidative stress via many antioxidant proteins, which are expected to be relevant to bacterial-associated gastric diseases. We aimed to investigate the expression of three essential antioxidants in H. pylori strains isolated from patients with different clinical outcomes. Methods: Forty H. pylori strains were isolated from endoscopic biopsy specimens of gastric mucosa from 13 patients with gastric cancer, 13 with peptic ulcer, and 14 with gastritis. The expression of thioredoxin 1 (Trx1), arginase (RocF), and alkyl hydroperoxide reductase (AhpC) in H. pylori was measured by real-time PCR. Comparisons among multiple sample sets were analyzed using a one-way ANOVA test. Pearson′s correlation test was used to assess relationships among multiple continuous variables.

Trx1 expression of H. pylori in gastric cancer and peptic ulcer tissues was higher than that in tissues with gastritis. RocF expression of H. pylori in gastric cancer tissues was higher than that in tissues exhibiting peptic ulcer and gastritis. However, we did not find any differences in AhpC expression in samples from patients with different clinical outcomes. The expression of Trx1 and RocF had a positive, linear correlation. The expression of Trx1 and AhpC had a positive correlation without a linear trend. We found no correlation between the expression of RocF and AhpC.

Our observations indicate that the expression of Trx1 and RocF in H. pylori might be related to gastric carcinogenesis. In H. pylori, the expression of members of the antioxidant system may be correlated and relevant to gastric cancer.

语种: 英语
所属项目编号: 81270475
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000335896400011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56582
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

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作者单位: Peking Univ, Dept Gastroenterol, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
Shi, Yan-yan,Chen, Mo,Zhang, Yue-xia,et al. Expression of three essential antioxidants of Helicobacter pylori in clinical isolates[J]. JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B,2014,15(5):500-506.
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