学科主题临床医学
Expression of three essential antioxidants of Helicobacter pylori in clinical isolates
Shi, Yan-yan; Chen, Mo; Zhang, Yue-xia; Zhang, Jing; Ding, Shi-gang
关键词Antioxidant Gastric Cancer Helicobacter Pylori Oxidative Stress
刊名JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
2014-05-01
DOI10.1631/jzus.B1300171
15期:5页:500-506
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]GASTRIC-CANCER ; THIOREDOXIN SYSTEM ; REDUCTASE ; ARGINASE ; STRESS ; CELLS ; IDENTIFICATION ; RESISTANCE ; BACTERIAL ; PROTEINS
英文摘要

Helicobacter pylori maintains long-term persistence in the host and combats oxidative stress via many antioxidant proteins, which are expected to be relevant to bacterial-associated gastric diseases. We aimed to investigate the expression of three essential antioxidants in H. pylori strains isolated from patients with different clinical outcomes. Methods: Forty H. pylori strains were isolated from endoscopic biopsy specimens of gastric mucosa from 13 patients with gastric cancer, 13 with peptic ulcer, and 14 with gastritis. The expression of thioredoxin 1 (Trx1), arginase (RocF), and alkyl hydroperoxide reductase (AhpC) in H. pylori was measured by real-time PCR. Comparisons among multiple sample sets were analyzed using a one-way ANOVA test. Pearson′s correlation test was used to assess relationships among multiple continuous variables.

Trx1 expression of H. pylori in gastric cancer and peptic ulcer tissues was higher than that in tissues with gastritis. RocF expression of H. pylori in gastric cancer tissues was higher than that in tissues exhibiting peptic ulcer and gastritis. However, we did not find any differences in AhpC expression in samples from patients with different clinical outcomes. The expression of Trx1 and RocF had a positive, linear correlation. The expression of Trx1 and AhpC had a positive correlation without a linear trend. We found no correlation between the expression of RocF and AhpC.

Our observations indicate that the expression of Trx1 and RocF in H. pylori might be related to gastric carcinogenesis. In H. pylori, the expression of members of the antioxidant system may be correlated and relevant to gastric cancer.

语种英语
WOS记录号WOS:000335896400011
项目编号81270475
资助机构National Natural Science Foundation of China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56582
专题北京大学第三临床医学院_临床流行病学研究中心
北京大学第三临床医学院_消化科
作者单位Peking Univ, Dept Gastroenterol, Hosp 3, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Shi, Yan-yan,Chen, Mo,Zhang, Yue-xia,et al. Expression of three essential antioxidants of Helicobacter pylori in clinical isolates[J]. JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B,2014,15(5):500-506.
APA Shi, Yan-yan,Chen, Mo,Zhang, Yue-xia,Zhang, Jing,&Ding, Shi-gang.(2014).Expression of three essential antioxidants of Helicobacter pylori in clinical isolates.JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B,15(5),500-506.
MLA Shi, Yan-yan,et al."Expression of three essential antioxidants of Helicobacter pylori in clinical isolates".JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B 15.5(2014):500-506.
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