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Concise syntheses of selective inhibitors against alpha-1,3-galactosyltransferase
Zhang, Guo-Liang; Zhang, Li-He; Ye, Xin-Shan1
刊名ORGANIC & BIOMOLECULAR CHEMISTRY
2010
DOI10.1039/c0ob00042f
8期:22页:5062-5068
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]ALPHA-GALACTOSYL EPITOPES ; ANTI-GAL ANTIBODY ; UDP-GAL ; GLYCOSYLTRANSFERASE INHIBITORS ; N-BUTYLDEOXYNOJIRIMYCIN ; IMINOSUGAR DERIVATIVES ; PROTEIN GLYCOSYLATION ; BIOLOGICAL EVALUATION ; POTENTIAL INHIBITORS ; BISUBSTRATE ANALOG
英文摘要

Several iminosugar-based uridine diphosphate galactose (UDP-Gal) mimetics 1-4 including D- and L-epimers were designed and synthesized by concise routes, and these synthetic compounds were evaluated for the inhibition of alpha-1,3- and beta-1,4-galactosyltransferases in vitro. The experimental data demonstrated that L-epimer 2 displayed the strongest inhibitory activity with moderate selectivity against alpha-1,3-galactosyltransferase.

语种英语
WOS记录号WOS:000283602000006
项目编号90713010 ; 2009ZX09501-011
资助机构National Natural Science Foundation of China ; Ministry of Science and Technology of China
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56584
专题北京大学药学院
北京大学药学院_药物化学系
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Guo-Liang,Zhang, Li-He,Ye, Xin-Shan. Concise syntheses of selective inhibitors against alpha-1,3-galactosyltransferase[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2010,8(22):5062-5068.
APA Zhang, Guo-Liang,Zhang, Li-He,&Ye, Xin-Shan.(2010).Concise syntheses of selective inhibitors against alpha-1,3-galactosyltransferase.ORGANIC & BIOMOLECULAR CHEMISTRY,8(22),5062-5068.
MLA Zhang, Guo-Liang,et al."Concise syntheses of selective inhibitors against alpha-1,3-galactosyltransferase".ORGANIC & BIOMOLECULAR CHEMISTRY 8.22(2010):5062-5068.
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