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学科主题: 药学
题名:
Concise syntheses of selective inhibitors against alpha-1,3-galactosyltransferase
作者: Zhang, Guo-Liang; Zhang, Li-He; Ye, Xin-Shan1
刊名: ORGANIC & BIOMOLECULAR CHEMISTRY
发表日期: 2010
DOI: 10.1039/c0ob00042f
卷: 8, 期:22, 页:5062-5068
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: ALPHA-GALACTOSYL EPITOPES ; ANTI-GAL ANTIBODY ; UDP-GAL ; GLYCOSYLTRANSFERASE INHIBITORS ; N-BUTYLDEOXYNOJIRIMYCIN ; IMINOSUGAR DERIVATIVES ; PROTEIN GLYCOSYLATION ; BIOLOGICAL EVALUATION ; POTENTIAL INHIBITORS ; BISUBSTRATE ANALOG
英文摘要:

Several iminosugar-based uridine diphosphate galactose (UDP-Gal) mimetics 1-4 including D- and L-epimers were designed and synthesized by concise routes, and these synthetic compounds were evaluated for the inhibition of alpha-1,3- and beta-1,4-galactosyltransferases in vitro. The experimental data demonstrated that L-epimer 2 displayed the strongest inhibitory activity with moderate selectivity against alpha-1,3-galactosyltransferase.

语种: 英语
所属项目编号: 90713010 ; 2009ZX09501-011
项目资助者: National Natural Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号: WOS:000283602000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56584
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Guo-Liang,Zhang, Li-He,Ye, Xin-Shan. Concise syntheses of selective inhibitors against alpha-1,3-galactosyltransferase[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2010,8(22):5062-5068.
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