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Intermittent hypoxia with or without hypercapnia is associated with tumorigenesis by decreasing the expression of brain derived neurotrophic factor and miR-34a in rats
Zhang Jing1; Guo Xu2; Shi Yanwei3; Ma Jing1; Wang Guangfa1
关键词Intermittent Hypoxia Hypercapnia Sleep Apnoea Tumorigenesis Brain Derived Neurotrophic Factor Mir-34a
刊名CHINESE MEDICAL JOURNAL
2014-01-05
DOI10.3760/cma.j.issn.0366-6999.20131683
127期:1页:43-47
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]General & Internal Medicine
关键词[WOS]SYNAPTIC PLASTICITY ; GENE-EXPRESSION ; CANCER ; APOPTOSIS ; EXPOSURE ; NEURONS ; STRESS ; TUMORS ; DNA
英文摘要

Background Very recent studies revealed that obstructive sleep apnoea (OSA) is a contributor of the increased incidence and mortality of cancer in humans, but mechanisms of how OSA promotes tumorigenesis remains largely unknown. We investigated whether intermittent hypoxia with and without hypercapnia plays a role in tumorigenesis.

Methods First, Sprague-Dawley (SD) male rats (12 weeks old) were subjected to different hypoxia exposures: intermittent hypoxia and intermittent hypoxia with hypercapnia; continuous hypoxia and normal air. The systemic application of chronic fast rate hypoxia with or without hypercapnia mimicked severe OSA patients with apnoea/hypopnea index equivalent to 60 events per hour. Then routine blood tests were performed and the levels of brain derived neurotrophic factor (BDNF) and miR-34a were examined.

Results In contrast to intermittent hypoxia with hypercapnia, both intermittent hypoxia and continuous hypoxia treatments caused significantly higher levels of haematology parameters than normoxia treatments. Compared to normoxia, intermittent hypoxia with hypercapnia exposure resulted in substantial decrease of serum BDNF and, miR-34a in the lower brainstem, while less pronounced results were found in intermittent hypoxia and continuous hypoxia exposure.

Conclusions The exposure of intermittent hypoxia with or without hypercapnia, mimicking the situations in severe OSA patients, was associated with, or even promoted tumorigenesis.

语种英语
所属项目编号81241004
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000330606800008
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56585
专题北京大学第一临床医学院
作者单位1.Peking Univ, Dept Resp & Crit Care Med, Hosp 1, Beijing 100034, Peoples R China
2.Liaoning Canc Hosp & Inst, Dept Neurosurg, Shenyang 110042, Liaoning, Peoples R China
3.Peking Univ, Shougang Hosp, Dept Resp Med, Beijing 100041, Peoples R China
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GB/T 7714
Zhang Jing,Guo Xu,Shi Yanwei,et al. Intermittent hypoxia with or without hypercapnia is associated with tumorigenesis by decreasing the expression of brain derived neurotrophic factor and miR-34a in rats[J]. CHINESE MEDICAL JOURNAL,2014,127(1):43-47.
APA Zhang Jing,Guo Xu,Shi Yanwei,Ma Jing,&Wang Guangfa.(2014).Intermittent hypoxia with or without hypercapnia is associated with tumorigenesis by decreasing the expression of brain derived neurotrophic factor and miR-34a in rats.CHINESE MEDICAL JOURNAL,127(1),43-47.
MLA Zhang Jing,et al."Intermittent hypoxia with or without hypercapnia is associated with tumorigenesis by decreasing the expression of brain derived neurotrophic factor and miR-34a in rats".CHINESE MEDICAL JOURNAL 127.1(2014):43-47.
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