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Caffeic acid phenethyl ester blocks free radical generation and 6-hydroxydopamine-induced neurotoxicity
Ma, Zhizhong; Wei, Xing; Fontanilla, Christine; Noelker, Cannen; Dodel, Richard; Hampel, Harald; Du, Yansheng
关键词Neuronal Cell Death Dopaminergic Neurons 6-ohda Antioxidant Free Radicals
刊名LIFE SCIENCES
2006-08-22
DOI10.1016/j.lfs.2006.03.050
79期:13页:1307-1311
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]CEREBELLAR GRANULE NEURONS ; NF-KAPPA-B ; PARKINSONS-DISEASE ; IN-VIVO ; PEROXYNITRITE ; TOXICITY ; CELLS ; NEURODEGENERATION ; TRANSFORMATION ; ANTIOXIDANTS
英文摘要

Neurotoxicity induced by 6-hydroxydopamine (6-OHDA) is believed to be due, in part, to the production of reactive oxygen species (ROS). Antioxidants protect neurons against 6-OHDA-induced neurotoxicity by inhibiting free radical generation. In this study, we investigated whether or not caffeic acid phenethyl ester (CAPE) could protect neurons against 6-OHDA-induced neurotoxicity in cultured rat rostral mesencephalic neurons (RMN) and cerebellar granule neurons (CGN). We now report that exposure of RMN and CGN to 6-OHDA (40 mu M for RMN and 70 mu M for CGN) resulted in significant increases in free radical production and death of both neuron types. Pretreatment with CAPE (10 gNT) for 2 h prevented both 6-OHDA-induced free radical generation and neurotoxicity. Furthermore, CAPE also attenuated H2O2-induced neurotoxicity. Our results strongly suggest that CAPE blocks 6-OHDA-induced neuronal death possibly by inhibiting 6-OHDA-induced free radical generation and blocking free radical-induced neurotoxicity in neurons. Both the antioxidative and neuroprotective effects of CAPE may be beneficial in the therapy for Parkinson′s disease and other neurodegenerative diseases. (c) 2006 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000239973600013
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56586
专题北京大学基础医学院
作者单位1.Peking Univ, Basic Med Sch, Beijing 100871, Peoples R China
2.Univ Bonn, Dept Neurol, D-5300 Bonn, Germany
3.Univ Munich, Dept Psychiat, D-8000 Munich, Germany
4.Indiana Univ, Sch Med, Dept Neurol, Indianapolis, IN 46202 USA
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GB/T 7714
Ma, Zhizhong,Wei, Xing,Fontanilla, Christine,et al. Caffeic acid phenethyl ester blocks free radical generation and 6-hydroxydopamine-induced neurotoxicity[J]. LIFE SCIENCES,2006,79(13):1307-1311.
APA Ma, Zhizhong.,Wei, Xing.,Fontanilla, Christine.,Noelker, Cannen.,Dodel, Richard.,...&Du, Yansheng.(2006).Caffeic acid phenethyl ester blocks free radical generation and 6-hydroxydopamine-induced neurotoxicity.LIFE SCIENCES,79(13),1307-1311.
MLA Ma, Zhizhong,et al."Caffeic acid phenethyl ester blocks free radical generation and 6-hydroxydopamine-induced neurotoxicity".LIFE SCIENCES 79.13(2006):1307-1311.
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